Exercise training rescues high fat diet-induced neuronal nitric oxide synthase expression in the hippocampus and cerebral cortex of mice

Nitric Oxide ◽  
2017 ◽  
Vol 66 ◽  
pp. 71-77 ◽  
Author(s):  
Yuki Tomiga ◽  
Saki Yoshimura ◽  
Ai Ito ◽  
Shihoko Nakashima ◽  
Kentaro Kawanaka ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cerebral Cortex ◽  
Nitric Oxide Synthase ◽  
Exercise Training ◽  
High Fat Diet ◽  
Neuronal Nitric Oxide Synthase ◽  
High Fat ◽  
Oxide Synthase

Exercise Training Rescues High Fat Diet-induced Neuronal Nitric Oxide Synthase Expression In Hippocampus And Cortex

2017 ◽  
Vol 49 (5S) ◽  
pp. 306-307
Author(s):  
Yuki Tomiga ◽  
Saki Yoshimura ◽  
Ai Ito ◽  
Kentaro Kawanaka ◽  
Yoshinari Uehara ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Exercise Training ◽  
High Fat Diet ◽  
Neuronal Nitric Oxide Synthase ◽  
High Fat ◽  
Oxide Synthase

scholarly journals Long-Term Consumption of High-Fat Diet in Rats: Effects on Microglial and Astrocytic Morphology and Neuronal Nitric Oxide Synthase Expression

2016 ◽  
Vol 37 (5) ◽  
pp. 783-789 ◽  
Author(s):  
Kinga Gzielo ◽  
Michal Kielbinski ◽  
Jakub Ploszaj ◽  
Krzysztof Janeczko ◽  
Stefan P. Gazdzinski ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
High Fat Diet ◽  
Neuronal Nitric Oxide Synthase ◽  
High Fat ◽  
Oxide Synthase

Deficiency of inducible nitric oxide synthase exacerbates hepatic fibrosis in mice fed high-fat diet

2004 ◽  
Vol 326 (1) ◽  
pp. 45-51 ◽  
Author(s):  
Yi Chen ◽  
Shigenari Hozawa ◽  
Sadaaki Sawamura ◽  
Shinkichi Sato ◽  
Naoto Fukuyama ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Hepatic Fibrosis ◽  
Inducible Nitric Oxide Synthase ◽  
High Fat Diet ◽  
High Fat ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

scholarly journals Mulberry Extract Attenuates Endothelial Dysfunction through the Regulation of Uncoupling Endothelial Nitric Oxide Synthase in High Fat Diet Rats

Nutrients ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 978 ◽  
Author(s):  
Geum-Hwa Lee ◽  
The-Hiep Hoang ◽  
Eun-Soo Jung ◽  
Su-Jin Jung ◽  
Soo-Wan Chae ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cells ◽  
Endothelial Dysfunction ◽  
Nitric Oxide Synthase ◽  
High Fat Diet ◽  
Endothelial Nitric Oxide Synthase ◽  
High Fat ◽  
Enos Uncoupling ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Dyslipidemia is associated with endothelial dysfunction, which is linked to nitric oxide (NO) biology. The coupling of endothelial NO synthase with cofactors is a major step for NO release. This study is aimed to investigate the vascular pharmacology effects of mulberry in rat thoracic aorta and human vascular endothelial cells. In vitro, we investigated the protective effects of the mulberry extract and its main component cyanidin-3-rutinoside (C-3-R), against oxidized low-density lipoprotein (ox-LDL)-induced endothelial nitric oxide synthase (eNOS) uncoupling. Whereas ox-LDL significantly decreased NO levels in endothelial cells, mulberry extract, and C-3-R significantly recovered NO levels and phospho-eNOS Thr495 and Ser1177 expression. In vivo, mulberry was administered to 60% of high-fat diet (w/w)-fed Sprague Dawley (SD) rats for six weeks, in which endothelium-dependent relaxations were significantly improved in organ bath studies and isometric tension recordings. Consistently, aortic expressions of phospho-eNOS and nitrotyrosine were increased. Mulberry also raised serum NO levels, increased phosphorylation of eNOS, and reduced nitrotyrosine and intracellular reactive oxygen species (ROS) in aortas, showing that mulberry preserves endothelium-dependent relaxation in aortas from high-fat diet rats. We suggest that this effect is mediated through enhanced NO bioavailability, in which the regulation of ROS and its reduced eNOS uncoupling are involved.

Effects of octreotide on nitric oxide synthase expression in the small intestine of high fat diet-induced obese rats

2012 ◽  
Vol 6 (4) ◽  
pp. e280-e287 ◽  
Author(s):  
Yan Ou ◽  
Rui Liu ◽  
Na Wei ◽  
Xian Li ◽  
Ou Qiang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Small Intestine ◽  
Nitric Oxide Synthase ◽  
High Fat Diet ◽  
High Fat ◽  
Obese Rats ◽  
Oxide Synthase

scholarly journals Neuronal nitric oxide synthase regulation of skeletal muscle functional hyperemia: exercise training and moderate compensated heart failure

Nitric Oxide ◽  
2018 ◽  
Vol 74 ◽  
pp. 1-9 ◽  
Author(s):  
Daniel M. Hirai ◽  
Steven W. Copp ◽  
Scott K. Ferguson ◽  
Clark T. Holdsworth ◽  
K. Sue Hageman ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Heart Failure ◽  
Skeletal Muscle ◽  
Nitric Oxide Synthase ◽  
Exercise Training ◽  
Neuronal Nitric Oxide Synthase ◽  
Functional Hyperemia ◽  
Synthase Regulation ◽  
Oxide Synthase
Sign in / Sign up

Export Citation Format

Share Document