64Cu-galectin-3-specific peptide as an in vivo PET imaging agent

2010 ◽  
Vol 37 (6) ◽  
pp. 725
Author(s):  
Susan L. Deutscher ◽  
Senthil R. Kumar ◽  
Thomas P. Quinn
Keyword(s):  
Pet Imaging ◽  
Imaging Agent ◽  
Galectin 3 ◽  
Specific Peptide

Synthesis and in vivo evaluation of [18F]N-(2-benzofuranylmethyl)-N′-[4-(2-fluoroethoxy)benzyl]piperazine, a novel σ1 receptor PET imaging agent

2011 ◽  
Vol 21 (22) ◽  
pp. 6820-6823 ◽  
Author(s):  
Iman A. Moussa ◽  
Samuel D. Banister ◽  
Nicolas Giboureau ◽  
Steven R. Meikle ◽  
Michael Kassiou
Keyword(s):  
Pet Imaging ◽  
Imaging Agent ◽  
In Vivo Evaluation ◽  
Σ1 Receptor

Radiosynthesis and in vivo evaluation of [ 11 C]MOV as a PET imaging agent for COX-2

2018 ◽  
Vol 28 (14) ◽  
pp. 2432-2435 ◽  
Author(s):  
Jaya Prabhakaran ◽  
Mark Underwood ◽  
Francesca Zanderigo ◽  
Norman R. Simpson ◽  
Anna R. Cooper ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Imaging Agent ◽  
In Vivo Evaluation ◽  
Cox 2

scholarly journals Design of a multivalent bifunctional chelator for diagnostic64Cu PET imaging in Alzheimer’s disease

2020 ◽  
Vol 117 (49) ◽  
pp. 30928-30933
Author(s):  
Hong-Jun Cho ◽  
Truc T. Huynh ◽  
Buck E. Rogers ◽  
Liviu M. Mirica
Keyword(s):  
Pet Imaging ◽  
Imaging Agent ◽  
Brain Uptake ◽  
Wild Type ◽  
Bifunctional Chelator ◽  
Positron Emission ◽  
Specific Affinity ◽  
Amyloid Aβ ◽  
5Xfad Mice

Herein, we report a64Cu positron emission tomography (PET) imaging agent that shows appreciable in vivo brain uptake and exhibits high specific affinity for beta-amyloid (Aβ) aggregates, leading to the successful PET imaging of amyloid plaques in the brains of 5xFAD mice versus those of wild-type mice. The employed approach uses a bifunctional chelator with two Aβ-interacting fragments that dramatically improves the Aβ-binding affinity and lipophilicity for favorable blood–brain barrier penetration, while the use of optimized-length spacers between the Cu-chelating group and the Aβ-interacting fragments further improves the in vivo Aβ-binding specificity and brain uptake of the corresponding64Cu PET imaging agent.

Synthesis and Initial In Vivo Evaluations of [ 11 C]WX‐132‐18B, a Microtubule PET Imaging Agent

2020 ◽  
Vol 5 (31) ◽  
pp. 9623-9625
Author(s):  
Kiran Kumar Solingapuram Sai ◽  
Jaya Prabhakaran ◽  
Naresh Damuka ◽  
Suzanne Craft ◽  
Shamyaa A. Rajagopal ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Imaging Agent

Successful Design of a Multivalent Bifunctional Chelator for Diagnostic 64Cu PET Imaging in Alzheimer’s Disease

2020 ◽  
Author(s):  
Hong-Jun Cho ◽  
Truc T. Huynh ◽  
Buck E. Rogers ◽  
Liviu M. Mirica
Keyword(s):  
Pet Imaging ◽  
Amyloid Plaques ◽  
Imaging Agent ◽  
Brain Uptake ◽  
Bifunctional Chelator ◽  
Successful Design ◽  
Specific Affinity ◽  
Amyloid Aβ ◽  
5Xfad Mice

Herein, we report to the best of our knowledge the first <sup>64</sup>Cu PET imaging agent that shows appreciable <i>in vivo</i> brain uptake and exhibits high specific affinity for beta-amyloid (Aβ) aggregates, leading to the successful PET imaging of amyloid plaques in the brains of 5xFAD mice versus those of WT mice. The employed approach uses a bifunctional chelator with two Aβ-interacting fragments that dramatically improves the Aβ-binding affinity and lipophilicity for favorable BBB penetration, while the use of optimized-length spacers between the Cu-chelating group and the Aβ-interacting fragments further improves the <i>in vivo</i> Aβ-binding specificity and brain uptake of the corresponding <sup>64</sup>Cu PET imaging agent.

scholarly journals Radiolabeling and in vitro and in vivo Characterization of [18F]FB-[R8,15,21, L17]-VIP as a PET Imaging Agent for Tumor Overexpressed VIP Receptors

2006 ◽  
Vol 68 (6) ◽  
pp. 319-325 ◽  
Author(s):  
Dengfeng Cheng ◽  
Duanzhi Yin ◽  
Gucai Li ◽  
Mingwei Wang ◽  
Shiqiang Li ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Imaging Agent ◽  
Vip Receptors ◽  
In Vivo Characterization

Synthesis, characterization and in vivo evaluation of [62Zn]–benzo-δ-sultam complex as a possible pet imaging agent

2014 ◽  
Vol 28 (9) ◽  
pp. 880-890 ◽  
Author(s):  
Mehdi Ghandi ◽  
Shahzad Feizi ◽  
Farhood Ziaie ◽  
Yousef Fazaeli ◽  
Behrooz Notash
Keyword(s):  
Pet Imaging ◽  
Imaging Agent ◽  
In Vivo Evaluation
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