Objective: To determine prevalence of malocclusion and orthodontic treatment needs in Down syndrome individuals among Sudanese population in Khartoum area.Materials & Method: A total of 75 (37 males and 38 females) Down syndrome individuals age ranging from 6-28 years were clinically examined after obtaining their guardian’s consent, malocclusion was determined based on Angle and Incisor classification. Exclusion criteria were included individuals who had history of extraction and orthodontic treatment.Data was analysed by using SPSS Version 17, at an alpha level 0.05 and 95% confidence limits.Result: Angle Class III and Incisor III malocclusion represents the most prevalent type of malocclusions (58.7%) Angle classification, (53.3%) Incisors classification. Angle Class III malocclusion was more frequent among females (60.5%) than in males (56.8%). Themajority of individuals with Down syndrome are in need of orthodontic treatment (85.3%).Conclusion: The prevalence of malocclusion and orthodontic treatment need among Sudanese Down syndrome individuals was high. Angle and Incisor Class III malocclusion representing commonest trait of malocclusion with more frequency in femalesthan males.Key word: down syndrome, Class III malocclusion, orthodontic treatment