Breast MRI for Evaluating Residual Tumor Size Following Neoadjuvant Chemotherapy: Clinicopathologic Factors and MRI Imaging Features Affecting Its Accuracy

Objectives: To investigate the accuracy of breast magnetic resonance imaging (MRI) for evaluating residual tumor size following neoadjuvant chemotherapy (NAC) and to identify clinicopathologic and MRI features affecting its accuracy. Materials and methods: We retrospectively assessed 109 women who underwent preoperative dynamic contrast-enhanced (DCE) MRI following NAC and subsequent surgery between April 2016 and August 2020. Preoperative MRI features, including Breast Imaging Reporting and Data System lexicon characteristics, size of residual enhancing lesion, tumor shrinkage pattern, and clinicopathologic features were investigated, and MRI and pathology findings were compared. Results: Residual tumor size on MRI showed high agreement with residual invasive tumor size on pathologic examination (ICC, 0.808, p<0.001). The residual tumor size measured by MRI and final pathologic size were concordant in 63/109 cases (57.8%), while MRI overestimated the size in 35/109 cases (32.1%). For estrogen receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative tumors, MRI tended to underestimate the residual tumor size compared with HER2-positive cancers (p=0.002) and triple-negative cancers (p=0.12). On MRI, tumors with concentric shrinkage patterns after NAC showed less size discrepancy with final pathologic tumor size than those with nonconcentric patterns (p=0.026). Conclusion: ER-positive/HER2-negative cancers are tended to underestimate the residual tumor size by MRI compared with other subtypes. Tumors with concentric shrinkage patterns after NAC showed less MRI/pathology size discrepancy.

Left lower lobar lung transplant

A lung transplant is an effective therapeutic option for selected patients with end-stage lung diseases. The shortage of donors is a major limitation for this life-saving therapy, especially in patients with small body sizes or with reduced thoracic cavities, who usually wait longer for grafts with adequate dimensions. Nonanatomic or sublobar graft resections can be sufficient in cases of a small size discrepancy between the donor and the recipient; however, in cases of a greater size mismatch, lobar reduction is mandatory but, because of the associated technical difficulties, only a few centers have adopted this procedure as part of their routine clinical practice. We describe a left upper lobectomy performed at the back table and the subsequent implantation of the left lower lobe in the recipient’s chest cavity.

A Rare Tooth Anomaly (Double Teeth) in Deciduous Teeth: A Case Report

Introduction: The Size and shape of the teeth are genetic characteristics. Anomaly in tooth size and shape is due to disturbances in a sequence of morph differentiation and his to differentiation in tooth bud formation periods and is more common in permanent dentition than deciduous teeth. The most common tooth size discrepancy is in the upper lateral incisor and upper and lowers 2nd premolar teeth. About 5% of malocclusions are due to tooth size discrepancy. For having the best occlusion, we must have the appropriate size and shape of teeth. As there is a relation between deciduous and permanent teeth, proper evaluation and timely intervention are essential for achieving a good occlusion in anterior and posterior segments of permanent teeth. Thus we need interceptive orthodontic in mixed dentition period with a good treatment plan for removing the malformed tooth at the proper time and appliance therapy for eruption guidance of other teeth. Case Report: A rare tooth anomaly (double teeth) in deciduous teeth: The case reported here is a 9- years old boy with a delayed eruption of the right lower permanent lateral incisor and gemination of lower right deciduous canine and crowded upper incisors that refer to the orthodontic department of dental school of Ahvaz Jundishapur University of Medical Sciences on7th October of 2020. Conclusion: After creating patient’s file, the further steps of molding from the patient and gathering all diagnostic records such as panoramic radiography, intraoral photography was carried out and ordered to remove the malformed baby tooth afterward. In the next stage, on the patient’s treatment, we installed a strap onto the patient’s first permanent molars, remolded them, then created a lingual arch to maintain the vegetative space in the lower permanent canine and prevent its collapse, and increased the patient’s overbite.

The Impact Study of Re-Measurement of Fishing Vessels Based at Tumumpa Coastal Fishing Port

Physical inspection of fishing vessels is part of the flow applied by the Directorate General of Capture Fisheries to verify and confirm the congruence of the actual dimension of the fishing vessel with the official document of fishing license. This inspection includes the calculation of the vessel size measured in Gross Tonnage (GT) which determine the amount of fishery retribution paid as Non-Tax State Revenue (PNBP) in the capture fisheries sector. The purpose of this study is to examine the size discrepancy due to mark down practices by re-measurement and to calculate PNBP based on mooring services at Tumumpa Coastal Fishing Port, Manado. A comparison method using a t-test is applied to investigate the difference between two measurements. Based on the test, there is a significant difference between written and actual measurements of GT which affects PNBP. Keywords: GT, PNBP, re-measurement, mark down, Tumumpa Coastal Fishing Port.

Modified Intra-alveolar appliance — Case report

Arch space/ Tooth size discrepancy occurs whenever there is a early loss of the deciduous molars which eventually leads to malocclusion. Prevention of this discrepancy has always been a challenge for a pediatric dentist. This case report describes modified bilateral distal shoe appliance fabricated due to inadequate abutment support.

Bolton tooth size discrepancy among different malocclusion groups in two different ethnic groups of Nepalese population

Introduction: The tooth size ratios may vary among different ethnic groups and different malocclusion groups. The objective of this study is to see the tooth size discrepancies in two major ethnic groups of Nepal; Indo-Aryans and Tibeto-Burmans and different malocclusion groups and compare it with the Bolton’s study. Materials and Method: The anterior and overall ratios were compared between Indo-Aryans and Tibeto-Burmans according to different malocclusion groups with Bolton’s study with one sample t-test. The differences in ratios in ethnic groups and gender were seen with one sample t-test. The differences in mesio-distal tooth width amongst the two ethnic groups were seen. One sample ANOVA was used to see any correlation between the ethnic groups and the different malocclusion groups. Result: The anterior ratio and overall ratio in Indo- Aryans and Tibeto-Burmans in all the malocclusion groups were greater than the Bolton’s study but was not statistically significant. There was significant differences in anterior ratio between Indo-Aryans (77.63 + 2.74%) and Tibeto-Burmans (78.51 + 2.76%), p value= 0.024. There were no statistical significant differences in the anterior and overall ratio amongst males and females. The mesio-distal tooth size was greater in Tibeto-Burmans as compared to Indo-Aryans expect for maxillary right and left central incisors. Conclusion: The Tibeto-Burmans had higher anterior ratio as compared to Indo-Aryans. The Tibeto-Burmans had broader teeth as compared to Indo-Aryans except for maxillary central incisors.

Ovary Development: Insights From a Three-Dimensional Imaging Revolution

The ovary is an indispensable unit of female reproduction and health. However, the study of ovarian function in mammals is hindered by unique challenges, which include the desynchronized development of oocytes, irregular distribution and vast size discrepancy of follicles, and dynamic tissue remodeling during each hormonal cycle. Overcoming the limitations of traditional histology, recent advances in optical tissue clearing and three-dimensional (3D) visualization offer an advanced platform to explore the architecture of intact organs at a single cell level and reveal new relationships and levels of organization. Here we summarize the development and function of ovarian compartments that have been delineated by conventional two-dimensional (2D) methods and the limits of what can be learned by these approaches. We compare types of optical tissue clearing, 3D analysis technologies, and their application to the mammalian ovary. We discuss how 3D modeling of the ovary has extended our knowledge and propose future directions to unravel ovarian structure toward therapeutic applications for ovarian disease and extending female reproductive lifespan.

Bony Union and Flap Resorption in Cranioplasty with Autologous Subcutaneous Pocket Preserved Bone Flap: Early Report on an Ambidirectional CT Scan-Based Study

Introduction Absence of sufficient number of prospective randomized controlled studies and comparatively small sample size and short follow-up period of most of the studies, available so far, have left ambiguity and lack of standardization of different aspects of cranioplasty. Materials and Methods This is an early report of a computed tomography scan image-based ambidirectional study on cranioplasties performed with autologous subcutaneous pocket preserved bone flaps. Retrospective arm compared bony union and factors influencing it between cranioplasties and craniotomies. Patients with poor bony union and aseptic resorption were followed up in the prospective arm. Results Retrospective arm of the study, followed up for five years (mean 32.2 months), comprised 42 patients as cases (Group 1) and 29 as controls (Group 2). Twenty-seven individuals (64.3%) in Group 1 had good bony union, as compared with 20 (68.9%) good unions in Group 2 out of the 29 patients. Four patients (9.5%) in Group 1 showed evidence of flap resorption, a finding absent in any patient in Group 2. Age, sex, smoking habits, superficial skin infection, and method of fixation did not appear to have any implication on bony union. Craniotomies done using Gigli saws fared better as compared with those done with pneumatic saw with lesser flap size–craniectomy size discrepancy, though it was not statistically significant. Fifteen patients have been included in the Prospective arm at the time of submission of this article. Conclusion Ours is a study with a small sample size, unable to put its weight on any side, but can surely add some more data to help the Neurosurgeons in choosing the best for their patients.

Fluidic Oscillators Mediating Generation of Microbubbles (Survey)

If a gas volume is distributed into many microbubbles of a sub-millimetre size, the total gas/liquid surface becomes very large. This increases overall heat and/or mass transport across the sum of surfaces. The paper discusses several applications in which the use of microbubbles increases efficiency of various processes, especially in wastewater treatment and in growing microorganisms such as algae, yeast, bacteria, or primitive fungi. The problem of microbubble generation by percolation in aerator is their coalescence into larger bubbles, whatever small are the pores in the aerator in which the microbubbles are generated. The solution of this size discrepancy question was found in agitating the gas flow by a fluidic oscillator prior to its injection through the aerator. The oscillator is a no-moving-part device, simple, inexpensive, resistant to external effects like acceleration or heat, and with long maintenance-free working life.