Macular neurosensory retinal detachment associated with topiramate use

2019 ◽  
Vol 94 (12) ◽  
pp. 614-618
Author(s):  
A. Muñoz Morales ◽  
J.L. Sánchez-Vicente ◽  
C. Franco Ruedas ◽  
J. de las Morenas Iglesias ◽  
M.Á. Espiñeira Periñán ◽  
...  
Keyword(s):  
Retinal Detachment ◽  
Neurosensory Retinal Detachment

scholarly journals DETECTION OF NEUROSENSORY RETINAL DETACHMENT COMPLICATING DEGENERATIVE RETINOSCHISIS BY ULTRA-WIDEFIELD FUNDUS AUTOFLUORESCENCE IMAGING

Retina ◽  
2020 ◽  
Vol 40 (5) ◽  
pp. 819-824
Author(s):  
Anibal Francone ◽  
Nikisha Kothari ◽  
Matthew Farajzadeh ◽  
Hamid Hosseini ◽  
Pradeep Prasad ◽  
...  
Keyword(s):  
Retinal Detachment ◽  
Fundus Autofluorescence ◽  
Autofluorescence Imaging ◽  
Neurosensory Retinal Detachment

scholarly journals Dome-Shaped Macula and Foveal Neurosensory Retinal Detachment—A Case Series

2019 ◽  
Vol 09 (03) ◽  
pp. 151-160
Author(s):  
Torres Soriano Mitzy ◽  
Dimattia Jesica ◽  
Gordon Maximiliano
Keyword(s):  
Retinal Detachment ◽  
Case Series ◽  
Neurosensory Retinal Detachment

scholarly journals Optical coherence tomography in assessment chorioretinal blood flow in patients with central serous chorioretinopathy

2016 ◽  
Vol 15 (4) ◽  
pp. 39-47
Author(s):  
S. I. Zhukova ◽  
A. N. Zlobina ◽  
T. N. Iureva ◽  
A. A. Shchuko
Keyword(s):  
Blood Flow ◽  
Optical Coherence Tomography ◽  
Retinal Detachment ◽  
Central Serous Chorioretinopathy ◽  
Structural Changes ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Pathological Process ◽  
Optical Coherence ◽  
Neurosensory Retinal Detachment

Introduction and purpose. Central serous chorioretinopathy - a disease that manifests itself serous detachment of the neurosensory retina and / or retinal pigment epithelium (RPE). Chronic course of pathological process may be complicated by the development of subretinal neovascularization, and is accompanied by a decrease in visual functions. Despite the large number of studies, there are no pathogenetically oriented and effective methods of treatment of central serous chorioretinopathy today, because there is no consensus on the causes of its origin. To evaluate the accuracy of the information content of chorioretinal blood flow changes in patients with central serous chorioretinopathy, to compare the degree of changes of RPE and hemodynamic disorders in different forms of the disease. Materials and Methods. The study involved 26 patients with central serous chorioretinopathy aged 35 to 54 years. To assess chorioretinal blood flow the optical coherence tomography (OCT) in retinal angiography mode was included in the volume of diagnostic examination. Results. It was demonstrated that the choroidal vessels and RPE are an original target in the realization of the pathological process in central serous chorioretinopathy. The changes in the pigment epithelium and the neurosensory retinal detachment, whose height ranged from 53.4 to 513.0 m (238.3 ± 80.4 - in acute and - 215.5 ± 129.9 - in chronic diseases) were revealed in all patients. In 45 % of cases of acute and 67 % in patients with a chronic form of disease the neurosensory retinal detachment combined with RPE detachment, preventing recovery of macular interface on a background of medical actions. Prolonged existence of ischemia and RPE detachment is accompanied by severe progressive degenerative changes in the retina as a whole, causing resistance to treatment. Conclusions. OCT in angiography mode in the diagnosis of various forms of chorioretinal central serous chorioretinopathy allows visualizing blood flow, evaluating the extent and nature of the structural changes of the retina taking into account hemodynamic disorders. The revealed changes of RPE and choroid, as classification and prognostic criteria of the disease, determine the effectiveness of treatment measures and prognosis of disease.

scholarly journals Bilateral Subfoveal Neurosensory Retinal Detachment Associated With MEK Inhibitor Use for Metastatic Cancer

2014 ◽  
Vol 132 (8) ◽  
pp. 1005 ◽  
Author(s):  
Tara A. McCannel ◽  
Bartosz Chmielowski ◽  
Richard S. Finn ◽  
Jonathan Goldman ◽  
Antoni Ribas ◽  
...  
Keyword(s):  
Retinal Detachment ◽  
Metastatic Cancer ◽  
Mek Inhibitor ◽  
Neurosensory Retinal Detachment

scholarly journals Acute exudative polymorphous vitelliform maculopathy during pembrolizumab treatment for metastatic melanoma: a case report

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ine Lambert ◽  
Giuseppe Fasolino ◽  
Gil Awada ◽  
Robert Kuijpers ◽  
Marcel ten Tusscher ◽  
...  
Keyword(s):  
Retinal Detachment ◽  
Checkpoint Inhibitors ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Anterior Segment ◽  
Subretinal Fluid ◽  
Additional Treatment ◽  
Central Visual Field ◽  
Immunomodulating Therapy ◽  
Neurosensory Retinal Detachment

Abstract Background The use of immunomodulating therapy to treat various cancers has been on the rise and these immune checkpoint inhibitors are known to cause ocular side effects. In this article a case of acute exudative polymorphous vitelliform maculopathy (AEPVM) is reported which developed during a first line treatment with pembrolizumab. Case presentation A 54-year-old woman was referred because of blurry vision in both eyes with a yellow spot in the central visual field of the left eye. These symptoms started after four treatments with pembrolizumab (a monoclonal antibody against the programmed cell death receptor-1) for a metastatic recurrent vaginal mucosal melanoma. Her best corrected visual acuity was 10/10 in both eyes with a correction of + 2.00 bilaterally. There were no inflammatory findings in the anterior segment or the vitreous. Fundoscopy revealed an attenuation of the foveal reflex with subtle yellow-white subretinal macular deposits (vitelliform lesions) in both eyes. Fluorescein angiography did not show staining or leakage in the mid-phase, neither a late staining. Spectral-domain optical coherence tomography of the macula illustrated bilateral neurosensory retinal detachment with a thick, highly reflective band at the outer photoreceptor segment. En face structural OCT at the level of the photoreceptors showed focal areas of increased signal corresponding to hyperreflective vitelliform material. The treatment with pembrolizumab was ceased immediately. During the following visits we slowly saw an improvement of the neurosensory retinal detachment. After almost four months a total resolution of the subretinal fluid was visualized in both eyes without the use of additional treatment, though the vitelliform deposits persisted. Conclusions The development of AEPVM in melanoma patients could be triggered by treatment with Pembrolizumab. Pembrolizumab has the potential to disturb indirectly the retinal pigment epithelium homeostasis with accumulation of lipofuscin deposits and subretinal fluid, both signs of AEPVM.

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