Anterior Chamber Angle Imaging with Swept-Source Optical Coherence Tomography: Measuring Peripheral Anterior Synechia in Glaucoma

Abstract This study compared the test–retest variabilities and measurement agreement of anterior chamber angle (ACA) dimensions measured by two anterior segment swept-source optical coherence tomography (SS-OCT)—the ANTERION (Heidelberg Engineering, Heidelberg, Germany) and CASIAII (Tomey, Nagoya, Japan). Thirty-eight subjects, 18 patients with primary angle closure and 20 healthy participants with open angles, were included. The mean age was 54.7 ± 15.8 years (range: 26–75 years). One eye of each subject was randomly selected for anterior segment imaging by ANTERION and CASIAII, using the same scan pattern (6 evenly spaced radial scans across the anterior segment for three times) in the same visit. The between- and within-instrument agreement and repeatability coefficients of angle open distance (AOD500), trabecular-iris space area (TISA500), lens vault (LV), scleral spur-scleral spur distance (SSD), anterior chamber depth (ACD), and pupil diameter (PD) were measured. The anterior and posterior boundaries of the cornea, iris, and lens were automatically segmented by the SS-OCT instruments; the scleral spur was manually located by a single masked observer. There were significant differences between ANTERION and CASIAII measurements; the SSD, PD, and ACD were smaller whereas AOD500 and TISA500 were greater in ANTERION compared with CASIAII (P < 0.001). Anterior segment measurements obtained from the two SS-OCT instruments showed strong associations (R2 ranged between 0.866 and 0.998) although the between-instrument agreement was poor; the spans of 95% limits of between-instrument agreement were ≥ 1.5-folds than the within-instrument agreement for either instrument. Whereas both SS-OCT instruments showed low test–retest measurement variabilities, the repeatability coefficients of AOD500, TISA500, ACD, and PD were slightly smaller for CASIAII than ANTERION (P ≤ 0.012).

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Investigation of anterior chamber angle by swept-source polarization sensitive optical coherence tomography

10.1117/12.808627 ◽

2009 ◽

Author(s):

Yoshiaki Yasuno ◽

Masahiro Yamanari ◽

Keisuke Kawana ◽

Masahiro Miura ◽

Shuichi Makita ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Anterior Chamber ◽

Optical Coherence ◽

Anterior Chamber Angle ◽

Swept Source ◽

Chamber Angle

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Anterior Chamber Angle Imaging with Swept-Source Optical Coherence Tomography: An Investigation on Variability of Angle Measurement

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.11-7507 ◽

2011 ◽

Vol 52 (12) ◽

pp. 8598 ◽

Cited By ~ 63

Author(s):

Shu Liu ◽

Marco Yu ◽

Cong Ye ◽

Dennis S. C. Lam ◽

Christopher Kai-shun Leung

Keyword(s):

Optical Coherence Tomography ◽

Anterior Chamber ◽

Angle Measurement ◽

Optical Coherence ◽

Anterior Chamber Angle ◽

Swept Source ◽

Chamber Angle

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High-speed, swept-source optical coherence tomography: a 3-dimensional view of anterior chamber angle recession

Acta Ophthalmologica Scandinavica ◽

10.1111/j.1600-0420.2006.00836.x ◽

2006 ◽

Vol 85 (6) ◽

pp. 684-685 ◽

Cited By ~ 9

Author(s):

Keisuke Kawana ◽

Yoshiaki Yasuno ◽

Toyohiko Yatagai ◽

Tetsuro Oshika

Keyword(s):

Optical Coherence Tomography ◽

Anterior Chamber ◽

High Speed ◽

Optical Coherence ◽

Anterior Chamber Angle ◽

Swept Source ◽

3 Dimensional ◽

Angle Recession ◽

Chamber Angle

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Anterior segment optical coherence tomography imaging and ocular biometry in cataract patients with open angle glaucoma comorbidity

BMC Ophthalmology ◽

10.1186/s12886-021-01874-x ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Giedre Pakuliene ◽

Kirilas Zimarinas ◽

Irena Nedzelskiene ◽

Brent Siesky ◽

Loreta Kuzmiene ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Anterior Chamber ◽

Optical Coherence ◽

Anterior Chamber Angle ◽

Swept Source ◽

Lens Position ◽

Ocular Biometry ◽

Cataract Patients ◽

Chamber Angle ◽

Glaucoma Group

Abstract Background Anterior chamber angle anatomy in perspective of ocular biometry may be the key element to intraocular pressure (IOP) reduction, especially in glaucoma patients. We aim to investigate anterior chamber angle and biometrical data prior to cataract surgery in patients with and without glaucoma comorbidity. Materials and methods This prospective comparative case-control study included 62 subjects (38 with cataract only and 24 with cataract and glaucoma). A full ophthalmic examination including, Goldmann applanation tonometry, anterior chamber swept source optical coherence tomography (DRI OCT Triton plus (Ver.10.13)) and swept source optical biometry (IOL Master 700 v1.7) was performed on all participants. Results We found that ocular biometry parameters and anterior chamber parameters were not significantly different among groups. However, when we added cut-off values for narrow angles, we found that glaucoma group tended to have more narrow angles than control group. IOP was higher in glaucoma group despite all glaucoma patients having medically controlled IOP. In all subjects, anterior chamber parameters correlated well with lens position (LP), but less with relative lens position, while LP cut-off value of 5.1 mm could be used for predicting narrow anterior chamber angle parameters. Conclusions Cataract patients tend to develop narrow anterior chamber angles. Anterior chamber angle parameters have a positive moderate to strong relationship with lens position. LP may be used predicting narrow angles.

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Anterior Chamber Angle Imaging With Swept-Source Optical Coherence Tomography

Journal of Glaucoma ◽

10.1097/ijg.0b013e31824485fa ◽

2013 ◽

Vol 22 (6) ◽

pp. 468-472 ◽

Cited By ~ 23

Author(s):

Hamish McKee ◽

Cong Ye ◽

Marco Yu ◽

Shu Liu ◽

Dennis S.C. Lam ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Anterior Chamber ◽

Optical Coherence ◽

Anterior Chamber Angle ◽

Swept Source ◽

Chamber Angle

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Assessment of anterior chamber configuration changes after phacoemulsification with swept-source optical coherence tomography

10.21203/rs.2.9863/v2 ◽

2020 ◽

Author(s):

Man Hu ◽

Qian Zheng ◽

Zhangliang Li ◽

Pingjun Chang ◽

Yun-e Zhao

Keyword(s):

Optical Coherence Tomography ◽

Cataract Surgery ◽

Anterior Chamber ◽

Optical Coherence ◽

Anterior Chamber Angle ◽

Swept Source ◽

Narrow Angle ◽

Significant Difference ◽

Shallow Anterior Chamber ◽

Chamber Angle

Abstract Background: To assess the changes of anterior chamber angle in patients with shallow anterior chamber and normal anterior chamber after phacoemulsification and intraocular lens implantation (IOL) using anterior segment swept-source optical coherence tomography (AS-SS-OCT). Methods: This was a prospective case control study; 60 eyes of 60 patients who scheduled for cataract surgery with normal intraocular pressure (IOP). Based on anterior chamber depth (ACD) and gonioscopy findings, the eyes were classified into two groups: shallow anterior chamber group with narrow angle (SAC group, 30 eyes)；and normal anterior chamber group with wide angle (NAC group, 30 eyes). Measurements of ACD, anterior chamber volume (ACV), Iris volume (IV), lens vault (LV) , angle opening distance (AOD), angle recess area (ARA), trabecular iris space area (TISA), and trabecular iris angle (TIA) were conducted in each group before and 3 months after surgery. Differences between the two groups were compared. Results: There was no significant difference in age, axial length (AL), corneal curvature, corneal diameter, IOP and IV between the SAC group and the NAC group before operation, except for the LV (p = 0.000). All angle parameters including ACD, ACV, AOD, ARA, TISA and TIA in both groups at 3 months post-surgery were significantly different from the preoperative values (p<0.01). In addition, there were significant differences in all angle parameters between two groups before and after operation (All P< 0.05). Besides, the TISA750 in superior quadrant, ACD and ACV were significantly smaller in the group of SAC than those in the group of NAC 3 months after operation (P = 0.041, 0.001 and 0.002, respectively). Conclusions: Cataract surgery can deepen anterior chamber and increase the width of anterior chamber angle in Chinese subjects, but the ACD and ACV in patients with shallow anterior chamber and narrow angle have not reached the normal level, presumably because the iris root of SAC group inserted more anteriorly than that of NAC group. Phacoemulsification may not completely eliminate the risk of glaucoma in NAC group of people after surgery.

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