Efficacy of adjunctive photodynamic therapy for chronic periodontitis undergoing scaling and root Planing: A Meta-analysis of randomized controlled trials

2022 ◽  
Vol 149 ◽  
pp. 107808
Author(s):  
Jungyul Song ◽  
Zhiqin Gao ◽  
Meihua Li
Keyword(s):  
Photodynamic Therapy ◽  
Randomized Controlled Trials ◽  
Chronic Periodontitis ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Scaling And Root Planing ◽  
Randomized Controlled ◽  
Root Planing

scholarly journals Mechanical Debridement with Antibiotics in the Treatment of Chronic Periodontitis: Effect on Systemic Biomarkers―A Systematic Review

2020 ◽  
Vol 17 (15) ◽  
pp. 5601 ◽  
Author(s):  
Sudhir L. Munasur ◽  
Eunice B. Turawa ◽  
Usuf M.E. Chikte ◽  
Alfred Musekiwa
Keyword(s):  
Systematic Review ◽  
Randomized Controlled Trials ◽  
Chronic Periodontitis ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Controlled Trials ◽  
Clinical Attachment Level ◽  
Randomized Controlled ◽  
Systemic Antibiotics ◽  
Attachment Level

In this systematic review, we assessed the effectiveness of systemic antibiotics as an adjunctive therapy to mechanical debridement in improving inflammatory systemic biomarkers, as compared to mechanical debridement alone, among adults with chronic periodontitis. We searched relevant electronic databases for eligible randomized controlled trials. Two review authors independently screened, extracted data, and assessed risk of bias. We conducted meta-analysis, assessed heterogeneity, and assessed certainty of evidence using GRADEPro software. We included 19 studies (n = 1350 participants), representing 18 randomized controlled trials and found very little or no impact of antibiotics on inflammatory biomarkers. A meta-analysis of eight studies demonstrated a mean reduction of 0.26 mm in the periodontal pockets at three months (mean difference [MD] −0.26, 95%CI: −0.36 to −0.17, n = 372 participants, moderate certainty of evidence) in favor of the antibiotics. However, results from five studies reporting clinical attachment level (mm) yielded little or no difference at three months (MD −0.16, 95% CI: −0.35 to 0.03, n = 217 participants) between antibiotic and placebo groups. There is little or no evidence that adjunctive systemic antibiotics therapy improves inflammatory systemic biomarkers, compared to mechanical debridement alone, among adults with chronic periodontitis.

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