Upregulation of presynaptic proteins and protein kinases associated with enhanced glutamate release from axonal terminals (synaptosomes) of the medial prefrontal cortex in rats with neuropathic pain

Pain ◽  
2014 ◽  
Vol 155 (2) ◽  
pp. 377-387 ◽  
Author(s):  
Kun-Long Hung ◽  
Su-Jane Wang ◽  
Ying-Chou Wang ◽  
Tsuey-Ru Chiang ◽  
Chia-Chuan Wang
Keyword(s):  
Neuropathic Pain ◽  
Prefrontal Cortex ◽  
Protein Kinases ◽  
Medial Prefrontal Cortex ◽  
Glutamate Release ◽  
Presynaptic Proteins

scholarly journals Morphological and functional reorganization of rat medial prefrontal cortex in neuropathic pain

2009 ◽  
Vol 106 (7) ◽  
pp. 2423-2428 ◽  
Author(s):  
A. E. Metz ◽  
H.-J. Yau ◽  
M. V. Centeno ◽  
A. V. Apkarian ◽  
M. Martina
Keyword(s):  
Neuropathic Pain ◽  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Functional Reorganization

scholarly journals Inhibition of Evoked Glutamate Release by Neurosteroid Allopregnanolone Via Inhibition of L-Type Calcium Channels in Rat Medial Prefrontal Cortex

2006 ◽  
Vol 32 (7) ◽  
pp. 1477-1489 ◽  
Author(s):  
Ai-Qun Hu ◽  
Ze-Min Wang ◽  
Dan-Mei Lan ◽  
Ying-Mei Fu ◽  
Yan-Hua Zhu ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Calcium Channels ◽  
Medial Prefrontal Cortex ◽  
Glutamate Release

scholarly journals Morphine selectively promotes glutamate release from glutamatergic terminals of projection neurons from medial prefrontal cortex to dopamine neurons of ventral tegmental area

2017 ◽  
Author(s):  
Li Yang ◽  
Ming Chen ◽  
Ping Zheng
Keyword(s):  
Prefrontal Cortex ◽  
Locomotor Activity ◽  
Ventral Tegmental Area ◽  
Medial Prefrontal Cortex ◽  
Lateral Hypothalamus ◽  
Basolateral Amygdala ◽  
Glutamate Release ◽  
Dopamine Neurons ◽  
Projection Neurons ◽  
Ventral Tegmental

AbstractRecently, we found that morphine promoted presynaptic glutamate release of dopamine (DA) neurons in the ventral tegmental area (VTA), which constituted the main mechanism for morphine-induced increase in VTA-DA neuron firing and related behaviors (Chen et al., 2015). However, what source of presynaptic glutamate release of DA neurons in the VTA is promoted by morphine remains unknown. To address this question, we used optogenetic strategy to selectively activate glutamatergic inputs from different projection neurons and then observed the effect of morphine on them. The result shows that morphine promotes glutamate release from glutamatergic terminals of projection neurons from the medial prefrontal cortex (mPFC) to VTA DA neurons, but has no effect on that from the basolateral amygdala (BLA) or the lateral hypothalamus (LH) to VTA DA neurons, and the inhibition of glutamatergic projection neurons from the mPFC to the VTA significantly reduces morphine-induced increase in locomotor activity of mice.

scholarly journals Dopamine Inputs from the Ventral Tegmental Area into the Medial Prefrontal Cortex Modulate Neuropathic Pain-Associated Behaviors in Mice

Cell Reports ◽  
2020 ◽  
Vol 33 (6) ◽  
pp. 108393
Author(s):  
Shuo Huang ◽  
Zizhen Zhang ◽  
Eder Gambeta ◽  
Shi Chen Xu ◽  
Catherine Thomas ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Prefrontal Cortex ◽  
Ventral Tegmental Area ◽  
Medial Prefrontal Cortex ◽  
Ventral Tegmental
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