Increased levels of total tau protein in the cerebrospinal fluid in Huntington’s disease

2011 ◽  
Vol 17 (9) ◽  
pp. 714-715 ◽  
Author(s):  
Radu Constantinescu ◽  
Megan Romer ◽  
Henrik Zetterberg ◽  
Lars Rosengren ◽  
Karl Kieburtz
Keyword(s):  
Cerebrospinal Fluid ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Tau Protein ◽  
Total Tau

scholarly journals Cerebrospinal fluid total tau concentration predicts clinical phenotype in Huntington's disease

2016 ◽  
Vol 139 (1) ◽  
pp. 22-25 ◽  
Author(s):  
Filipe Brogueira Rodrigues ◽  
Lauren Byrne ◽  
Peter McColgan ◽  
Nicola Robertson ◽  
Sarah J. Tabrizi ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Clinical Phenotype ◽  
Total Tau

scholarly journals Cerebrospinal fluid neurogranin and TREM2 in Huntington’s disease

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Lauren M. Byrne ◽  
Filipe B. Rodrigues ◽  
Eileanoir B. Johnson ◽  
Enrico De Vita ◽  
Kaj Blennow ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Huntington's Disease ◽  
Huntington’S Disease

scholarly journals Nε-(γ-l-Glutamyl)-l-lysine (GGEL) is increased in cerebrospinal fluid of patients with Huntington's disease

2008 ◽  
Vol 79 (5) ◽  
pp. 1109-1112 ◽  
Author(s):  
Thomas M. Jeitner ◽  
Mikhail B. Bogdanov ◽  
Wayne R. Matson ◽  
Yevgeny Daikhin ◽  
Marc Yudkoff ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Huntington's Disease ◽  
Huntington’S Disease

Total tau protein in cerebrospinal fluid as a prognostic marker in anti-N-methyl-D-aspartate receptor encephalitis

2017 ◽  
Vol 381 ◽  
pp. 656
Author(s):  
H. Nakano ◽  
T. Ikeda ◽  
A. Shimizu ◽  
T. Ozaki ◽  
J. Komatsu ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Prognostic Marker ◽  
Tau Protein ◽  
Total Tau ◽  
Aspartate Receptor

Total Tau Protein in Cerebrospinal Fluid and Diffusion-Weighted MRI as an Early Diagnostic Marker for Creutzfeldt-Jakob Disease

2007 ◽  
Vol 24 (3) ◽  
pp. 207-212 ◽  
Author(s):  
Katsuya Satoh ◽  
Susumu Shirabe ◽  
Akira Tsujino ◽  
Hiroto Eguchi ◽  
Masakatsu Motomura ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Tau Protein ◽  
Diagnostic Marker ◽  
Diffusion Weighted Mri ◽  
Total Tau ◽  
Diffusion Weighted ◽  
Jakob Disease ◽  
And Diffusion ◽  
Early Diagnostic

scholarly journals Huntington’s disease cerebrospinal fluid seeds aggregation of mutant huntingtin

2015 ◽  
Vol 20 (11) ◽  
pp. 1286-1293 ◽  
Author(s):  
Z Tan ◽  
W Dai ◽  
T G M van Erp ◽  
J Overman ◽  
A Demuro ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Mutant Huntingtin

scholarly journals An immuno-enrichment free, validated quantification of tau protein in human CSF by LC-MS/MS

2021 ◽  
Author(s):  
Wade Self ◽  
John P. Savaryn ◽  
Khader Awwad ◽  
Michael Schulz
Keyword(s):  
Cerebrospinal Fluid ◽  
Neurodegenerative Diseases ◽  
Tau Protein ◽  
Therapeutic Antibodies ◽  
Alzheimers Disease ◽  
Total Tau ◽  
Human Cerebrospinal Fluid ◽  
Fit For Purpose

Aims: Tau protein is a key target of interest in developing therapeutics for neurodegenerative diseases. Here, we sought to develop a method that quantifies extracellular tau protein concentrations human cerebrospinal fluid (CSF) without antibody-based enrichment strategies. Results: We demonstrate that the fit-for-purpose validated method in Alzheimers Disease CSF is limited to quasi quantitative measures of tau surrogate peptides. We also provide evidence that CSF total Tau measures by LC-MS are feasible in the presence of monoclonal therapeutic antibodies in human CSF. Conclusion: Our Tau LC-MS/MS method is a translational bioanalytical tool for assaying target

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