A proteome is an efficient rendition of a genome, unswervingly controlling various cancer processes. Molecular
mechanisms of several cancer processes have been unraveled by proteomic approach. Thus far, numerous tumors of diverse
status have been investigated by two-dimensional electrophoresis. Numerous biomarkers have been recognized and precise
categorization of apparent lesions has led to the timely detection of various cancers in persons at peril. Currently used pioneering approaches and technologies in proteomics have led to highly sensitive assays of cancer biomarkers and improved
the early diagnosis of various cancers. The discovery of novel and definite biomarker signatures further widened our perceptive of the disease and novel potent drugs for efficient and aimed therapeutic outcomes in persistent cancers have
emerged. However, a major limitation, even today, of proteomics is resolving and quantifying the proteins of low abundance. Despite the rapid development of proteomic technologies and their applications in cancer management, annulling the
shortcomings of present proteomic technologies and development of better methods are still desirable. The main objectives
of this review are to discuss the developing aspects, merits and demerits of pharmacoproteomics, redox proteomics, novel
approaches and therapies being used for various types of cancer based on proteome studies.
Laser Capture Microdissection and Colorectal Cancer Proteomics
