7-Nitroindazole, a neuronal nitric oxide synthase inhibitor, impairs passive-avoidance and elevated plus-maze memory performance in rats

2007 ◽  
Vol 87 (4) ◽  
pp. 434-443 ◽  
Author(s):  
Furuzan Yildiz Akar ◽  
Guner Ulak ◽  
Pelin Tanyeri ◽  
Faruk Erden ◽  
Tijen Utkan ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Passive Avoidance ◽  
Elevated Plus Maze ◽  
Memory Performance ◽  
Neuronal Nitric Oxide Synthase ◽  
Nitric Oxide Synthase Inhibitor ◽  
Plus Maze ◽  
Synthase Inhibitor ◽  
Oxide Synthase

scholarly journals 7-Nitro indazole, a neuron-specific nitric oxide synthase inhibitor, produces amnesia in the chick.

1994 ◽  
Vol 1 (4) ◽  
pp. 213-216
Author(s):  
C Hölscher
Keyword(s):  
Nitric Oxide ◽  
Synaptic Plasticity ◽  
Nitric Oxide Synthase ◽  
Blood Vessel ◽  
Passive Avoidance ◽  
Avoidance Task ◽  
Nitric Oxide Synthase Inhibitor ◽  
Nos Inhibitors ◽  
Synthase Inhibitor ◽  
Oxide Synthase

7-Nitro indazole (7-NI), which is selective for the neuronal isoform of nitric oxide synthase (NOS), was tested in a passive avoidance task in the chick. Injection of 50 mg/kg i.p. pretraining had amnesic effects for the task when tested 30 min, 2 or 24 hr after training. Injections post-training had no effect. Because 7-NI does not inhibit the endothelial isoform of NOS, it does not affect blood vessel relaxation, as nonspecific inhibitors do. This effect on blood vessels could explain the amnestic effects produced by nonspecific NOS inhibitors. The results support the theory that NO is a neuronal transmitter that is important in processes of synaptic plasticity and learning.

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