Adjunctive use of antimicrobial photodynamic therapy in the treatment of medication-related osteonecrosis of the jaws: A case report

Background: In spite of some advances in periodontal generative methods, it is impossible to stop progressive Loss of supporting alveolar bone in some end-stage periodontitis. The aim of this study is to report a kind of treatment modality which was seemed to be successes full in maintaining teeth. In this case-report, a hopeless tooth was saved by combined non-surgical periodontalendodontal treatment and antimicrobial photodynamic therapy (aPDT). Case Report: A 58-year-old male presented with a chief complaint of pain and mobility of tooth number 38. Clinical examinations revealed a periodontic-endodontic lesion with clinical attachment loss exceeding 10 mm and grade III mobility. To preserve the tooth, we operated nonsurgical periodontal treatment including scaling and root planning (SRP) plus root canal therapy (RCT) combined with intra-root canal non-aPDT laser decontamination. Then we applied laser pocket therapy with and without aPDT. Following 6 months of the aPDT treatment, the mobility and pocket depth of the tooth improved from grade III to I and from 10 to 3 millimeters respectively. Conclusion: aPDT is a novel adjunctive therapy that can be used for various conditions with microbial etiology. This case report demonstrated that aPDT might be effective in the treatment of periodontic-endodontic lesions in a hopeless tooth.

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Methylene blue-mediated antimicrobial photodynamic therapy: A novel strategy for digital dermatitis-associated sole ulcer in a cow – A case report

Photodiagnosis and Photodynamic Therapy ◽

10.1016/j.pdpdt.2018.09.004 ◽

2018 ◽

Vol 24 ◽

pp. 121-122 ◽

Cited By ~ 4

Author(s):

Fábio Parra Sellera ◽

Ronaldo Gomes Gargano ◽

Carolina dos Anjos ◽

Maurício da Silva Baptista ◽

Martha Simões Ribeiro ◽

...

Keyword(s):

Methylene Blue ◽

Photodynamic Therapy ◽

Case Report ◽

Antimicrobial Photodynamic Therapy ◽

Digital Dermatitis ◽

Novel Strategy

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Endodontic treatment of a large periapical cyst with the aid of antimicrobial photodynamic therapy - Case report

Brazilian Dental Science ◽

10.14295/bds.2019.v22i4.1745 ◽

2019 ◽

Vol 22 (4) ◽

pp. 561-568

Author(s):

Amjad Abu Hasna ◽

Carlos Henrique Ferrari ◽

Cláudio Antonio Talge Carvalho

Keyword(s):

Photodynamic Therapy ◽

Case Report ◽

Calcium Hydroxide ◽

Diode Laser ◽

Bone Repair ◽

Irradiation Time ◽

Radiographic Examination ◽

Antimicrobial Photodynamic Therapy ◽

Traditional Treatment ◽

Digital Palpation

Introduction: Periapical cysts, especially those of great extension, represent a challenge for endodontics, since they are not repaired with traditional treatment. The aim of this case report was to evaluate the effectivity of antimicrobial photodynamic therapy “aPDT” when associated with calcium hydroxide Ca(OH)2 in treating such cysts. Case report: A 40-year-old female patient complained of bulging in the upper anterior region of the mouth. The clinical examination showed an extensive swollen periodontal area, painful with digital palpation, with a negative response to thermal tests on teeth 11 and 21. After traditional treatment, the canals of 11 and 21 were filled with photosensitizer methylene blue 0.005% pre irradiation time (PIT) of 5 minutes and irradiation by low power diode laser with visible red wavelength (660 nm) during 2 minutes without intervals, using an optical fiber delivering system with a helical movement from apical to cervical. Then the canal were filled with Ca(OH)2 paste for 45 days being changed each 15 days, and repeating the radiation. Results: After 45 days, the patient already had a bulging remission, with painless resistance to apical pressure in the region and signs of bone repair at the radiographic examination, and total absence of signs or symptoms. Conclusion: the association of aPDT with Ca(OH)2 paste is effective in treating of periapical lesions of great extension and avoid surgical treatment.Keywords: Antimicrobial; Calcium hydroxide; Diode Laser; Periapical cysts; Photodynamic Therapy; Root canal treatment.

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Photodynamic Therapy as an adjunct in the Treatment of Medication-Related Osteonecrosis of the Jaw: A Case Report

Journal of lasers in medical sciences ◽

10.34172/jlms.2021.12 ◽

2021 ◽

Vol 12 (1) ◽

pp. e12-e12

Author(s):

Marcelo Vieira da Costa Almeida ◽

Antonio C. Moura ◽

Lúcia Santos ◽

Luciana Gominho ◽

Ully Dias Nascimento Távora Cavalcanti ◽

...

Keyword(s):

Photodynamic Therapy ◽

Case Report ◽

Osteonecrosis Of The Jaw ◽

Complete Regression ◽

Antimicrobial Photodynamic Therapy ◽

Clinical Protocols ◽

History Of ◽

Lesion Regression ◽

The Right

Introduction: Medication-related osteonecrosis of the jaw (MRONJ) corresponds to an adverse effect of the use of drugs such as bisphosphonates and denosumab. This condition is often associated with pain, infection, purulent secretion, paraesthesia, tooth mobility and halitosis, decreasing the patient’s quality of life. The management of MRONJ tends to be conservative, through the guidance of oral hygiene, antibiotic therapy and mouthwashes. However, the use of antimicrobial photodynamic therapy (aPDT) has shown promise in the treatment of these injuries. The purpose of this article is to report a case of MRONJ treatment associated with aPDT. Case Report: A 75-year-old patient, with a history of breast cancer and use of intravenous Zoledronic Acid, presented with bilateral MRONJ lesions in tuberosity on the right and left sides. Treatment was conservatively instituted with the use of aPDT as an adjuvant. After 12 aPDT sessions, complete regression of the lesion was observed. However, after two weeks, the presence of a new lesion was noted, this time in the anterior region of the maxilla. The same protocol previously established was followed and after two aPDT sessions, the patient returned with complete lesion regression. Conclusion: The use of aPDT may represent an important adjuvant within a set of clinical protocols in the treatment of MRONJ.

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