scholarly journals A tagged parathyroid hormone derivative as a carrier of antibody cargoes transported by the G protein coupled PTH1 receptor

Peptides ◽  
2014 ◽  
Vol 60 ◽  
pp. 71-79 ◽  
Author(s):  
Xavier Charest-Morin ◽  
Jean-Philippe Fortin ◽  
Robert Lodge ◽  
Isabelle Allaeys ◽  
Patrice E. Poubelle ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
G Protein ◽  
G Protein Coupled ◽  
Pth1 Receptor

scholarly journals Parathyroid hormone receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

2019 ◽  
Vol 2019 (4) ◽  
Author(s):  
Alessandro Bisello ◽  
Michael Chorev ◽  
Peter A. Friedman ◽  
Tom Gardella ◽  
Rebecca Hills ◽  
...  
Keyword(s):  
Amino Acids ◽  
Parathyroid Hormone ◽  
G Protein ◽  
Hormone Receptors ◽  
G Protein Coupled Receptors ◽  
Related Peptide ◽  
Parathyroid Hormone Related Peptide ◽  
Pthrp Receptor ◽  
G Protein Coupled ◽  
Pth1 Receptor

The parathyroid hormone receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Parathyroid Hormone Receptors [47]) are family B G protein-coupled receptors. The parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor (PTH1 receptor) is activated by precursor-derived peptides: PTH (84 amino acids), and PTHrP (141 amino-acids) and related peptides (PTH-(1-34), PTHrP-(1-36)). The parathyroid hormone 2 receptor (PTH2 receptor) is activated by the precursor-derived peptide TIP39 (39 amino acids). [125I]PTH may be used to label both PTH1 and PTH2 receptors.

scholarly journals Apoptosis Mediated by Activation of the G Protein-Coupled Receptor for Parathyroid Hormone (PTH)/ PTH-Related Protein (PTHrP)

2000 ◽  
Vol 14 (2) ◽  
pp. 241-254 ◽  
Author(s):  
Paul R. Turner ◽  
Suzanne Mefford ◽  
Sylvia Christakos ◽  
Robert A. Nissenson
Keyword(s):  
Parathyroid Hormone ◽  
G Protein ◽  
Related Protein ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

Bioinformatics and type II G-protein-coupled receptors

2002 ◽  
Vol 30 (4) ◽  
pp. 473-479 ◽  
Author(s):  
S. M. Foord ◽  
S. Jupe ◽  
J. Holbrook
Keyword(s):  
Parathyroid Hormone ◽  
G Protein ◽  
Sequence Homology ◽  
G Protein Coupled Receptors ◽  
Type Ii ◽  
Corticotrophin Releasing Factor ◽  
Large N ◽  
G Protein Coupled ◽  
7Tm Receptors

The best known family B, or Type II, G-protein-coupled receptors (GPCRs) recognize peptides as ligands. The receptors for corticotrophin-releasing factor, parathyroid hormone and secretin typify this group. However, there are only 15 such GPCRs. Many other receptors share sequence homology and have been assigned to this family. The ten ‘Frizzled’ and one ‘Smoothened’ receptors show the lowest sequence homology and are not necessarily G-protein coupled. Drosophila genetics have enabled our understanding of their biology. In contrast, relatively little is known about the largest group with family B, the 33 ‘large amino termini’ or large N-terminal family B seven-transmembrane (LNB 7TM) receptors. This review highlights the similarities found between family B receptors and provides a classification of LNB 7TM receptors.

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