No influence of moderate hepatic impairment on the pharmacokinetics of lumiracoxib, an oral COX-2 selective inhibitor

2004 ◽  
Vol 50 (2) ◽  
pp. 181-186 ◽  
Author(s):  
J KALBAG
Keyword(s):  
Hepatic Impairment ◽  
Selective Inhibitor ◽  
Moderate Hepatic Impairment ◽  
Cox 2

The effect of mild and moderate hepatic impairment on the pharmacokinetics of valdecoxib, a selective COX-2 inhibitor

2005 ◽  
Vol 61 (4) ◽  
pp. 247-256 ◽  
Author(s):  
Nenad Sarapa ◽  
Margaret R. Britto ◽  
Michelle B. Mainka ◽  
Kourosh Parivar
Keyword(s):  
Hepatic Impairment ◽  
Moderate Hepatic Impairment ◽  
Cox 2

Cox 2 selective inhibitor prevents the implantaion of eutopic endometrium to ectopic sites in rats

2003 ◽  
Vol 80 ◽  
pp. 32
Author(s):  
Sachiko Matsuzaki ◽  
Michel Canis ◽  
Claude Darcha ◽  
Nobuo Yaegashi ◽  
Kunihiro Okamura ◽  
...  
Keyword(s):  
Selective Inhibitor ◽  
Eutopic Endometrium ◽  
Cox 2

Reduced incidence of upper gastrointestinal ulcer complications with the COX-2 selective inhibitor, valdecoxib

2004 ◽  
Vol 20 (5) ◽  
pp. 527-538 ◽  
Author(s):  
J. L. Goldstein ◽  
G. M. Eisen ◽  
N. Agrawal ◽  
W. F. Stenson ◽  
J. D. Kent ◽  
...  
Keyword(s):  
Selective Inhibitor ◽  
Gastrointestinal Ulcer ◽  
Ulcer Complications ◽  
Cox 2 ◽  
Upper Gastrointestinal

2.224 Effect of moderate hepatic impairment and cigarette smoking on the pharmacokinetics of istradefylline

2007 ◽  
Vol 13 ◽  
pp. S104 ◽  
Author(s):  
N. Rao ◽  
P. Chaikin ◽  
B. Dvorchik ◽  
N. Sussman ◽  
A. Mori ◽  
...  
Keyword(s):  
Cigarette Smoking ◽  
Hepatic Impairment ◽  
Moderate Hepatic Impairment

scholarly journals Isoorientin, a Selective Inhibitor of Cyclooxygenase-2 (COX-2) from the Tubers of Pueraria tuberosa

2015 ◽  
Vol 10 (10) ◽  
pp. 1934578X1501001 ◽  
Author(s):  
Manne Sumalatha ◽  
Rachakunta Munikishore ◽  
Aluru Rammohan ◽  
Duvvuru Gunasekar ◽  
Kotha Anil Kumar ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Methanol Extract ◽  
2D Nmr ◽  
Docking Studies ◽  
Selective Inhibitor ◽  
Pueraria Tuberosa ◽  
Nmr Techniques ◽  
Cox 2 ◽  
Plant Sources ◽  
Cox 1

Bioassay-guided fraction of the methanol extract of the roots of Pueraria tuberose DC yielded puerarin, an isoflavone C-glycoside (PT-1), isoorientin, a flavone C-glycoside (PT-2) and mangiferin, a xanthone C-glycoside (PT-3). The extracts and the isolated compounds were screened for potent antiinflammatory components inhibiting the cyclooxygenases (COX-1 and COX-2) and 5-lipoxygenase (5-LOX), the target enzymes of inflammation, by employing spectroscopic/polorographic methods. Among these, isoorientin was found to be a potent inhibitorof COX-2with an IC50 value of 39 μM. Docking studies were carried out to understand the interactions of isorientin (PT-2) with COX-2. The structures of the isolates were determined by mass spectrometry and 2D-NMR techniques including HSQC, HMBC, NOESY and 1H-1H COSY experiments. Although isoorientin and mangiferin have been reported from several plant sources, this is the first report of their isolation from a Pueraria species.

The Effect of Mild or Moderate Hepatic Impairment (Cirrhosis) on the Pharmacokinetics of Zileuton

1995 ◽  
Vol 29 (Supplement 2) ◽  
pp. 49-61 ◽  
Author(s):  
Walid M. Awni ◽  
John H. Cavanaugh ◽  
Rene A. Braeckman ◽  
Sou-yie (Maury) Chu ◽  
Karen J. Patterson ◽  
...  
Keyword(s):  
Hepatic Impairment ◽  
Moderate Hepatic Impairment
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