Fat preference deficits and experience-induced recovery in, global taste-deficient Trpm5 and Calhm1 knockout mice

2022 ◽  
pp. 113695
Author(s):  
Anthony Sclafani ◽  
Karen Ackroff
Keyword(s):  
Knockout Mice ◽  
Fat Preference

scholarly journals Maltodextrin and Fat Preference Deficits in "Taste-Blind" P2X2/P2X3 Knockout Mice

2014 ◽  
Vol 39 (6) ◽  
pp. 507-514 ◽  
Author(s):  
A. Sclafani ◽  
K. Ackroff
Keyword(s):  
Knockout Mice ◽  
Fat Preference

Fat preference and acceptance in the CD36 knockout mice.

Appetite ◽  
2007 ◽  
Vol 49 (1) ◽  
pp. 329 ◽  
Author(s):  
A. Sclafani ◽  
K. Ackroff ◽  
N. Abumrad
Keyword(s):  
Knockout Mice ◽  
Fat Preference

scholarly journals Greater reductions in fat preferences in CALHM1 than CD36 knockout mice

2018 ◽  
Vol 315 (3) ◽  
pp. R576-R585 ◽  
Author(s):  
Anthony Sclafani ◽  
Karen Ackroff
Keyword(s):  
Fatty Acid ◽  
Knockout Mice ◽  
Dietary Fat ◽  
Taste Receptor ◽  
Wild Type ◽  
Short Term ◽  
Low Concentrations ◽  
Oil Emulsions ◽  
Fat Preference

Several studies indicate an important role of gustation in intake and preference for dietary fat. The present study compared fat preference deficits produced by deletion of CD36, a putative fatty acid taste receptor, and CALHM1, an ion channel responsible for release of the ATP neurotransmitter used by taste cells. Naïve CD36 knockout (KO) mice displayed reduced preferences for soybean oil emulsions (Intralipid) at low concentrations (0.1–1%) compared with wild-type (WT) mice in 24 h/day two-bottle tests. CALHM1 KO mice displayed even greater Intralipid preference deficits compared with WT and CD36 KO mice. These findings indicate that there may be another taste receptor besides CD36 that contributes to fat detection and preference. After experience with concentrated fat (2.5–5%), CD36 KO and CALHM1 KO mice displayed normal preferences for 0.1–5% fat, although they still consumed less fat than WT mice. The experience-induced rescue of fat preferences in KO mice can be attributed to postoral fat conditioning. Short-term (3-min) two-bottle tests further documented the fat preference deficits in CALHM1 KO mice but also revealed residual preferences for concentrated fat (5–10%), which may be mediated by odor and/or texture cues.

Heat stable toxin of E. coli (STa) stimulates duodenal mucosal bicarbonate secretion in cystic fibrosis knockout mice

2001 ◽  
Vol 120 (5) ◽  
pp. A137-A137
Author(s):  
D CHILDS ◽  
D CROMBIE ◽  
V PRATHA ◽  
Z SELLERS ◽  
D HOGAN ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Knockout Mice ◽  
Bicarbonate Secretion ◽  
E Coli ◽  
Heat Stable

Sa1495 LEPTIN AUGMENTS BILIARY HYPERPLASIA AND HEPATIC FIBROSIS IN MDR2-KNOCKOUT MICE

2020 ◽  
Vol 158 (6) ◽  
pp. S-1310
Author(s):  
Rebekah John ◽  
Anca D. Petrescu ◽  
Stephanie Grant ◽  
Elaina Williams ◽  
Sharon DeMorrow
Keyword(s):  
Hepatic Fibrosis ◽  
Knockout Mice

Abstract #219: Evidence of Insulitis in Signal Transducer and Activator of Transcription 5 (Stat5) Knockout Mice

2017 ◽  
Vol 23 ◽  
pp. 39
Author(s):  
Aili Guo ◽  
Nigel Daniels ◽  
Craig Nunemaker ◽  
Samantha J. Shaw ◽  
Karen Coschigano
Keyword(s):  
Knockout Mice ◽  
Signal Transducer

Xpa and Xpa/p53 +/- Knockout Mice: Overview of Available Data

2001 ◽  
Vol 29 (5) ◽  
pp. 117-127 ◽  
Author(s):  
Coen F. van Kreijl ◽  
Peter A. McAnulty ◽  
Rudolf B. Beems ◽  
An Vynckier ◽  
Harry van Steeg ◽  
...  
Keyword(s):  
Knockout Mice
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