Vincan- and eburnan-type alkaloids from Tabernaemontana bovina and their hypoglycemic activity

2021 ◽  
Vol 190 ◽  
pp. 112859
Author(s):  
Yang Yu ◽  
Mei-Fen Bao ◽  
Sheng-Zhuo Huang ◽  
Jing Wu ◽  
Xiang-Hai Cai
Keyword(s):  
Hypoglycemic Activity

Bio-guided fractionation of essential oils looking for plant bioactive secondary metabolites with potential hypoglycemic activity

2019 ◽  
Author(s):  
B Sgorbini ◽  
F Capetti ◽  
C Cagliero ◽  
A Marengo ◽  
S Acquadro ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Essential Oils ◽  
Hypoglycemic Activity ◽  
Bioactive Secondary Metabolites

Evaluation of Picralima nitida hypoglycemic activity, toxicity and analytical standards

Planta Medica ◽  
2006 ◽  
Vol 72 (11) ◽  
Author(s):  
SI Inya-Agha ◽  
SC Ezea ◽  
OA Odukoya
Keyword(s):  
Hypoglycemic Activity ◽  
Analytical Standards

Oral hypoglycemic activity of water extract from Ya-Tevada, Malvastrum Coromandelianum Garcke, equivalent to insulin injection

Planta Medica ◽  
2006 ◽  
Vol 72 (11) ◽  
Author(s):  
S Jesadanont ◽  
C Sitthiwej ◽  
S Poungshompoo ◽  
S Pongsamart
Keyword(s):  
Water Extract ◽  
Insulin Injection ◽  
Hypoglycemic Activity ◽  
Malvastrum Coromandelianum

Synthesis and hypoglycemic activity of esterified-derivatives of mangiferin

2014 ◽  
Vol 11 (3) ◽  
pp. 296-301 ◽  
Author(s):  
Xue-Jian LI ◽  
Zheng-Cai DU ◽  
Yan HUANG ◽  
Bu-Ming LIU ◽  
Wen-Ji HU ◽  
...  
Keyword(s):  
Hypoglycemic Activity ◽  
Derivatives Of

Comparison of Hypoglycemic and Antioxidant Activities of the Compounds Isolated from Ficus hispida Linn. and Ficus pomifera Wall

2020 ◽  
Vol 10 (5) ◽  
pp. 621-630
Author(s):  
Ashalata Nepram ◽  
Sujata Wangkheirakpam ◽  
Warjeet S. Laitonjam
Keyword(s):  
Methanol Extract ◽  
Antioxidant Activities ◽  
Tolerance Test ◽  
Chloroform Extract ◽  
Diabetic Rats ◽  
Hypoglycemic Activity ◽  
North East India ◽  
North East ◽  
Dpph Method ◽  
Ficus Hispida

Background: Traditional knowledge has been a legacy of the past to the present. Barks of Ficus hispida Linn. and leaves of Ficus pomifera Wall. (Moraceae) have been used traditionally for the treatment of diabetes in North-east India and many other places. As many drugs have been developed from traditional plants, the authors have taken up the plants for the study of hypoglycemic activity. Objective: To investigate the hypoglycemic activities of the triterpenoids isolated from the plants and their antioxidant activities. Methods: The bioactive compounds were determined by biochemical analysis, antioxidant activity using DPPH method. Hypoglycemic activity was detected using glucose tolerance test in normal rats and alloxan induced diabetic rats with Gliclazide as standard. Results: The biochemicals and trace elements were present in appreciable amounts. Triterpenoids, (1-5), from F. pomifera and 19-hydroxyphlogacantholide (6), 3-O-[ß-D-glucopyranosyl-(1’→2’)-α- L-rhamnopyranosyl-phlogacanthoside] (7) and galanolactone (8) along with stigmasterol (9), stigmasta- 5,22-dien-7-on-3ß-ol (10), 5-(decahydro-1,1,4a-trimethyl-6-methylene-5-yl)-3-methylpent-2- enal (11), stigmasterol glucoside (12) and stigmast-4-en-3-one (13) from F. hispida Linn., respectively, were isolated. The different extracts of the barks and leaves of these plants along with the isolated compounds had antioxidant and hyploglycemic activities. Conclusions: The five triterpenoids (1-5) were isolated from the methanol extract of the leaves of F. pomifera, and compounds (6-13) were isolated from the chloroform extract of the barks of F. hispida. Methanol extract of the leaves of F. pomifera and the chloroform extract of the barks of F. hispida; compounds (1-13) isolated from these two plants reduced DPPH free radicals in a concentrationdependent manner. It was also observed that the methanol and chloroform extracts of the plants, F. pomifera and F. hispida respectively, and the compounds (1, 6 & 7) exhibited anti-diabetic properties and also caused a highly significant reduction in the blood glucose levels of normal rats.

Synthesis, molecular modeling, selective aldose reductase inhibition and hypoglycemic activity of novel meglitinides

2021 ◽  
pp. 104909
Author(s):  
Manar G. Salem ◽  
Yasmine M. Abdel Aziz ◽  
Marwa Elewa ◽  
Mohamed S. Nafie ◽  
Hosam A. Elshihawy ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Aldose Reductase ◽  
Hypoglycemic Activity ◽  
Aldose Reductase Inhibition

Hypoglycemic activity of a polyphenolic oligomer-rich extract of Cinnamomum parthenoxylon bark in normal and streptozotocin-induced diabetic rats

Phytomedicine ◽  
2009 ◽  
Vol 16 (8) ◽  
pp. 744-750 ◽  
Author(s):  
Q. Jia ◽  
X. Liu ◽  
X. Wu ◽  
R. Wang ◽  
X. Hu ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Hypoglycemic Activity

Structural characterization and evaluation of antioxidant, anticancer and hypoglycemic activity of radiation degraded oat (Avena sativa) β- glucan

2018 ◽  
Vol 144 ◽  
pp. 218-230 ◽  
Author(s):  
Peerzada R. Hussain ◽  
Sarver A. Rather ◽  
Prashant P. Suradkar
Keyword(s):  
Structural Characterization ◽  
Avena Sativa ◽  
Hypoglycemic Activity

Synthesis and hypoglycemic activity of substituted 8-(1-piperazinyl)imidazo[1,2-a]pyrazines

1992 ◽  
Vol 35 (21) ◽  
pp. 3845-3857 ◽  
Author(s):  
Laura C. Meurer ◽  
Richard L. Tolman ◽  
Edward W. Chapin ◽  
Richard Saperstein ◽  
Pasquale P. Vicario ◽  
...  
Keyword(s):  
Hypoglycemic Activity
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