Cadinane sesquiterpenoids from the fungus Antrodiella albocinnamomea and their inhibitory activity against nitric oxide production

Eight new diarylheptanoids, a 1.2:1 mixture of (3S)- and (3 R)-1-(4-hydroxyphenyl)-7-phenyl-(4 E,6 E)-4,6-heptadien-3-ol (1a and 1b), a racemic mixture of (3S)- and (3 R)-1-(4-hydroxyphenyl)-3-methoxy-7-phenyl-(4 E,6 E)-4,6-heptadiene (2a and 2b), a ca. 1:1 mixture of (3S)- and (3 R)-1-(4-hydroxy-3-methoxyphenyl)-3-methoxy-7-phenyl)-(4 E,6 E)-4,6-heptadiene (3a and 3b), 3-acetoxy-1-(3,4-dihydroxyphenyl)-7-phenylheptan-5-ol (4), (3 R)-1-(4,5-dihydroxyphenyl)-7-phenyl-(6 E)-6-hepten-3,2′-epoxide (5), and thirteen known diarylheptanoids, 6-12, a 3:1 mixture of 13a and 13b, and 14-17, were isolated from the rhizomes of Curcuma comosa from Sakon Nakhon, northeastern part of Thailand. The isolated compounds were evaluated for their antiinflammatory activities on the inhibition of lipopolysaccharide-induced nitric oxide production in macrophage RAW 264.7 cells and the diarylheptanoids 1a and 1b mixture and 14 exhibited potent inhibitory activity.

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Melampolides from the Leaves of Smallanthus sonchifolius and Their Inhibitory Activity of LPS-Induced Nitric Oxide Production

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.56.199 ◽

2008 ◽

Vol 56 (2) ◽

pp. 199-202 ◽

Cited By ~ 24

Author(s):

Seong Su Hong ◽

Seon A Lee ◽

Xiang Hua Han ◽

Min Hee Lee ◽

Ji Sang Hwang ◽

...

Keyword(s):

Nitric Oxide ◽

Inhibitory Activity ◽

Nitric Oxide Production ◽

Smallanthus Sonchifolius ◽

Oxide Production

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Prenylated Flavonoids from the Heartwood ofArtocarpuscommuniswith Inhibitory Activity on Lipopolysaccharide-Induced Nitric Oxide Production

Journal of Natural Products ◽

10.1021/np0600346 ◽

2006 ◽

Vol 69 (4) ◽

pp. 719-721 ◽

Cited By ~ 53

Author(s):

Ah-Reum Han ◽

You-Jin Kang ◽

Tri Windono ◽

Sang Kook Lee ◽

Eun-Kyoung Seo

Keyword(s):

Nitric Oxide ◽

Inhibitory Activity ◽

Nitric Oxide Production ◽

Prenylated Flavonoids ◽

Oxide Production

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ChemInform Abstract: Melampolides from the Leaves of Smallanthus sonchifolius and Their Inhibitory Activity of LPS-Induced Nitric Oxide Production.

ChemInform ◽

10.1002/chin.200832183 ◽

2008 ◽

Vol 39 (32) ◽

Author(s):

Bang Yeon Hwang ◽

et al. et al.

Keyword(s):

Nitric Oxide ◽

Inhibitory Activity ◽

Nitric Oxide Production ◽

Smallanthus Sonchifolius ◽

Oxide Production

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Rotenoid Derivatives from Derris Trifoliata with Nitric Oxide Production Inhibitory Activity

Natural Product Communications ◽

10.1177/1934578x1200701117 ◽

2012 ◽

Vol 7 (11) ◽

pp. 1934578X1200701

Author(s):

Chihiro Ito ◽

Tomiyasu Murata ◽

Hugh T.-W. Tan ◽

Norio Kaneda ◽

Hiroshi Furukawa ◽

...

Keyword(s):

Nitric Oxide ◽

Inhibitory Activity ◽

Chemical Constituents ◽

Interferon Γ ◽

Raw 264.7 Cells ◽

Raw 264.7 ◽

Nitric Oxide Production ◽

Murine Macrophage ◽

Isolation And Identification ◽

Oxide Production

Study of the chemical constituents of the stems of Derris trifoliata Lour. (Leguminosae) collected in Singapore led to the isolation and identification of three known and two new rotenoid derivatives. The new derivatives, named derrisfolin A (1) and B (2), inhibited nitric oxide production in murine macrophage-like RAW 264.7 cells stimulated with interferon-γ and lipopolysaccharide.

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Inhibition of nitric oxide production in lipopolysaccharide-activated RAW 264.7 macrophages by Jeju plant extracts

Interdisciplinary Toxicology ◽

10.2478/v10102-009-0022-2 ◽

2009 ◽

Vol 2 (4) ◽

pp. 245-249 ◽

Cited By ~ 53

Author(s):

Eun-Jin Yang ◽

Eun-Young Yim ◽

Gwanpil Song ◽

Gi-Ok Kim ◽

Chang-Gu Hyun

Keyword(s):

Nitric Oxide ◽

Plant Extracts ◽

Inhibitory Activity ◽

Inflammatory Diseases ◽

No Production ◽

Raw 264.7 ◽

Nitric Oxide Production ◽

Raw 264.7 Macrophages ◽

Oxide Production ◽

Potent Inhibition

Inhibition of nitric oxide production in lipopolysaccharide-activated RAW 264.7 macrophages by Jeju plant extractsNitric oxide (NO) produced in large amounts by inducible nitric oxide synthase (iNOS) is known to be responsible for the vasodilation and hypotension observed during septic shock and inflammation. Thus, inhibitors of iNOS may be useful candidates for the treatment of inflammatory diseases accompanied by the overproduction of NO. In this study, we prepared alcoholic extracts of Jeju plants and screened them for their inhibitory activity against NO production in lipopolysaccharide (LPS)-activated macrophages. Among the 260 kinds of plant extract tested, 122 extracts showed potent inhibitory activity towards NO production by more than 25% at a concentration of 100 μg/mL. Plants such asMalus sieboldii, Vaccinium oldhamii, Corylus hallaisanensis, Carpinus laxiflora, Styrax obassia, andSecurinega suffruticosashowed the most potent inhibition (above 70%) at a concentration of 100 μg/mL. The cytotoxic effects of the plant extracts were determined by colorimetric MTT assays and most plant extracts exhibited only moderate cytotoxicity at 100 μg/mL. Therefore, these plants should be considered promising candidates for the further purification of bioactive compounds and would be useful for the treatment of inflammatory diseases accompanying overproduction of NO.

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