Poster 378: Nerve Regeneration and Improvement of Bladder Function in Complete Spinal Cord Transected Rats Treated With a Peripheral Nerve Graft, Acidic Fibroblast Growth Factor, and Chondroitinase ABC

PM&R ◽  
2010 ◽  
Vol 2 ◽  
pp. S166-S166
Author(s):  
Vernon W. Lin ◽  
Warren Alilain ◽  
Yu-Shang Lee ◽  
Ching-Yi Lin ◽  
Jerry Silver ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Growth Factor ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Fibroblast Growth Factor ◽  
Nerve Graft ◽  
Bladder Function ◽  
Fibroblast Growth ◽  
Acidic Fibroblast Growth Factor ◽  
Peripheral Nerve Graft

Acidic Fibroblast Growth Factor Enhances Peripheral Nerve Regeneration in Vivo

1989 ◽  
Vol 83 (6) ◽  
pp. 1020-1021 ◽  
Author(s):  
Peter G. Cordeiro ◽  
Brooke R. Seckel ◽  
Stuart A. Lipton ◽  
Patricia A. DʼAmore ◽  
John Wagner ◽  
...  
Keyword(s):  
Growth Factor ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Fibroblast Growth Factor ◽  
Peripheral Nerve Regeneration ◽  
Fibroblast Growth ◽  
Acidic Fibroblast Growth Factor

Acidic Fibroblast Growth Factor Enhances Peripheral Nerve Regeneration in Vivo

1989 ◽  
Vol 83 (6) ◽  
pp. 1013-1019 ◽  
Author(s):  
Peter G. Cordeiro ◽  
Brooke R. Seckel ◽  
Stuart A. Lipton ◽  
Patricia A. DʼAmore ◽  
John Wagner ◽  
...  
Keyword(s):  
Growth Factor ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Fibroblast Growth Factor ◽  
Peripheral Nerve Regeneration ◽  
Fibroblast Growth ◽  
Acidic Fibroblast Growth Factor

scholarly journals Reduction in post-spinal cord injury spasticity by combination of peripheral nerve grafting and acidic fibroblast growth factor infusion in monkeys

2021 ◽  
Vol 49 (6) ◽  
pp. 030006052110222
Author(s):  
Wei-Ming Sun ◽  
Chao-Lin Ma ◽  
Jiang Xu ◽  
Ji-Ping He
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Growth Factor ◽  
Peripheral Nerve ◽  
Fibroblast Growth Factor ◽  
Nerve Grafting ◽  
Fibroblast Growth ◽  
Acidic Fibroblast Growth Factor ◽  
Cord Injury ◽  
Peripheral Nerve Grafting

Objective Spasticity is a frequent complication after spinal cord injury (SCI), but the existing therapies provide only limited relief and are associated with adverse reactions. Therefore, we aimed to develop a novel strategy to ameliorate the spasticity induced by SCI. Methods This nonrandomized controlled study used a repeated measurement design. The study involved four monkeys, two of which served as controls and only underwent spinal cord hemisection surgery at the T8 spine level. The other two monkeys underwent transplantation of sural nerve segments into the injured sites and long-term infusion of acidic fibroblast growth factor (aFGF). All monkeys received postoperative exercise training and therapy. Results The combined therapy substantially reduced the spasticity in leg muscle tone, patella tendon reflex, and fanning of toes. Although all monkeys showed spontaneous recovery of function over time, the recovery in the controls reached a plateau and started to decline after 11 weeks. Conclusions The combination of peripheral nerve grafting and aFGF infusion may serve as a complementary approach to reduce the signs of spasticity in patients with SCI.

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