Poster 357 Brain as a Chronic Pain Generator: Chronic Lumbar Back Pain Persisting After Complete Thoracic Spinal Cord Injury: A Case Report

PM&R ◽  
2011 ◽  
Vol 3 ◽  
pp. S297-S297
Author(s):  
Daniel A. Winkle ◽  
Sharon K. McDowell
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Chronic Pain ◽  
Back Pain ◽  
Case Report ◽  
Thoracic Spinal Cord ◽  
Lumbar Back Pain ◽  
Thoracic Spinal ◽  
Cord Injury ◽  
Pain Generator

Poster 424: Simultaneously Diagnosed Pulmonary Thromboembolism and Hemopericardium in Thoracic Spinal Cord Injury Patients: A Case Report

PM&R ◽  
2010 ◽  
Vol 2 ◽  
pp. S185-S186
Author(s):  
In-Sung Choi ◽  
Jae-Young Han ◽  
Min-Kyung Lee ◽  
Sam-Gyu Lee ◽  
Hyo-Jeong Sun
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Case Report ◽  
Pulmonary Thromboembolism ◽  
Thoracic Spinal Cord ◽  
Thoracic Spinal ◽  
Cord Injury

scholarly journals Thoracic spinal cord injury without radiologic abnormality in a pediatric patient case report

2018 ◽  
Vol 2018 (10) ◽  
Author(s):  
Juan Iaconis Campbell ◽  
Federico Coppola ◽  
Emilio Volpe ◽  
Eduardo Salas Lopez
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Case Report ◽  
Pediatric Patient ◽  
Patient Case ◽  
Thoracic Spinal Cord ◽  
Thoracic Spinal ◽  
Cord Injury ◽  
Radiologic Abnormality

scholarly journals Exertional hypotension in thoracic spinal cord injury: case report

Spinal Cord ◽  
1992 ◽  
Vol 30 (4) ◽  
pp. 261-266 ◽  
Author(s):  
M L King ◽  
D M Freeman ◽  
J T Pellicone ◽  
E R Wanstall ◽  
L D Bhansali
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Case Report ◽  
Thoracic Spinal Cord ◽  
Thoracic Spinal ◽  
Cord Injury

scholarly journals Sonic Hedgehog modulates the inflammatory response and improves functional recovery after spinal cord injury in a thoracic contusion–compression model

2021 ◽  
Author(s):  
Hao Zhang ◽  
Alexander Younsi ◽  
Guoli Zheng ◽  
Mohamed Tail ◽  
Anna-Kathrin Harms ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Sonic Hedgehog ◽  
Functional Recovery ◽  
Intrathecal Administration ◽  
Neuroprotective Effects ◽  
Thoracic Spinal Cord ◽  
Shh Pathway ◽  
Thoracic Spinal ◽  
Cord Injury

Abstract Purpose The Sonic Hedgehog (Shh) pathway has been associated with a protective role after injury to the central nervous system (CNS). We, therefore, investigated the effects of intrathecal Shh-administration in the subacute phase after thoracic spinal cord injury (SCI) on secondary injury processes in rats. Methods Twenty-one Wistar rats were subjected to thoracic clip-contusion/compression SCI at T9. Animals were randomized into three treatment groups (Shh, Vehicle, Sham). Seven days after SCI, osmotic pumps were implanted for seven-day continuous intrathecal administration of Shh. Basso, Beattie and Bresnahan (BBB) score, Gridwalk test and bodyweight were weekly assessed. Animals were sacrificed six weeks after SCI and immunohistological analyses were conducted. The results were compared between groups and statistical analysis was performed (p < 0.05 was considered significant). Results The intrathecal administration of Shh led to significantly increased polarization of macrophages toward the anti-inflammatory M2-phenotype, significantly decreased T-lymphocytic invasion and significantly reduced resident microglia six weeks after the injury. Reactive astrogliosis was also significantly reduced while changes in size of the posttraumatic cyst as well as the overall macrophagic infiltration, although reduced, remained insignificant. Finally, with the administration of Shh, gain of bodyweight (216.6 ± 3.65 g vs. 230.4 ± 5.477 g; p = 0.0111) and BBB score (8.2 ± 0.2 vs. 5.9 ± 0.7 points; p = 0.0365) were significantly improved compared to untreated animals six weeks after SCI as well. Conclusion Intrathecal Shh-administration showed neuroprotective effects with attenuated neuroinflammation, reduced astrogliosis and improved functional recovery six weeks after severe contusion/compression SCI.

Thoracic spinal cord injury without major bone injury associated with ossification of the ligamentum flavum

2019 ◽  
Vol 24 (1) ◽  
pp. 174-177 ◽  
Author(s):  
Masaaki Machino ◽  
Shiro Imagama ◽  
Keigo Ito ◽  
Kei Ando ◽  
Kazuyoshi Kobayashi ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Ligamentum Flavum ◽  
Thoracic Spinal Cord ◽  
Thoracic Spinal ◽  
Bone Injury ◽  
Cord Injury
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