No. 93 Botulinum Toxin Type A Injections in Severe Peripheral Facial Nerve Paralysis: 3 Case Reports

PM&R ◽  
2014 ◽  
Vol 6 (8) ◽  
pp. S114
Author(s):  
Agustin Gutierrez Ruiz ◽  
Leire Ortiz Fernandez ◽  
M. Paz ◽  
Abaitua Ezquerra ◽  
Maite Pacheco Boiso
Author(s):  
Noha Abdelkader ◽  
Elif Keskin Arslan ◽  
Hilal Erol- Coskun ◽  
Gözde Küçüksolak ◽  
Yusuf Cem Kaplan

Objective: To evaluate the available human data to-date in order to assess whether the prenatal exposure to botulinum toxin type A (BTX-A) is associated with major congenital malformations and other adverse pregnancy outcomes. Methods: Searches were conducted in PubMed/MEDLINE and Reprotox in November  2017. Cohort and case-control studies, case series, case reports were the primary data of interest. Results: No controlled studies but case series and case reports of therapeutic BTX-A administration during pregnancy were identified. Case reports regarding pregnant women with botulism were also reviewed. Conclusions: Limited data suggests that BTX-A exposure for therapeutic indications during pregnancy does not seem to be associated with an increase in risk of major congenital malformations. Rates of fetal loss were substantially different between prospective and retrospective data. Controlled epidemiological studies are needed to refute or support our findings.


2020 ◽  
Vol 96 (2) ◽  
pp. 59-67
Author(s):  
L.B. Zavaliy ◽  
S.S. Petrikov ◽  
G.R. Ramazanov ◽  
D.S. Kasatkin ◽  
K.I. Chekhonatskaya

Facial nerve neuropathy can manifest itself with gross organic and functional disorders. The esthetic defect worsens social adaptation and quality of life. However, there is no consensus, protocol or algorithm of treatment of the patient with this pathology. In article we present a modern way of treatment and rehabilitation of patients with neuropathy of a facial nerve of various etiology. Conservative and surgical types of treatment are applied during the different periods of a disease. Surgical methods of treatment can be divided into two groups: reconstructive, decompressive and also plastic. The choice of a type of operation is defined individually with many factors, including an etiology and time of a disease. Both the new and tested by time techniques are applied. Conservative therapy includes corticosteroids, antiviral, antibacterial drugs depending on a clinical situation. Traditionally specialists of policlinics and hospitals appoint additional therapy (group B vitamins, cholinesterase inhibitors, antioxidants, neuroprotectors, nootropic drugs), however single small researches couldn't enforce these drugs recommendations. Botulinum toxin type A is effective in the acute and chronic periods of a disease. Depending on a clinical situation of botulinum toxin type A are injected both in affected, and in healthy part of the face. Patients with incomplete eye closure are given keratoprotection as early as possible, and blepharography is performed in case of pronounced deficit. As an alternative method, botulinum toxin type A injections are used into the upper eyelid lifting muscle. One of the most effective methods of rehabilitation of patients with facial nerve neuropathy is therapeutic physical education such as neuromuscular retraining with biological feedback. The most optimal combination is the injection of botulinum toxin type A and therapeutic physical education.


2013 ◽  
Vol 29 (3) ◽  
pp. 175-178 ◽  
Author(s):  
Elaine R. McElhinny ◽  
Isaac Reich ◽  
Benjamin Burt ◽  
Ronald Mancini ◽  
Edward J. Wladis ◽  
...  

2009 ◽  
Vol 19 ◽  
pp. S548
Author(s):  
E. Marini ◽  
P. Georgila ◽  
N. Kouroumalos ◽  
V. Nikolopoulos ◽  
N. Tagaris ◽  
...  

2014 ◽  
Vol 78 (6) ◽  
pp. 50 ◽  
Author(s):  
O. R. Orlova ◽  
M. A. Akulov ◽  
D. Iu. Usachev ◽  
S. V. Taniashin ◽  
V. O. Zakharov ◽  
...  

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