Synthesis, crystal structure and antifungal activity of a Ni(II) complex of a new hydrazone derived from antihypertensive drug hydralazine hydrochloride

Polyhedron ◽  
2013 ◽  
Vol 63 ◽  
pp. 207-213 ◽  
Author(s):  
Emmanuel N. Nfor ◽  
Ahmad Husian ◽  
Felicite Majoumo-Mbe ◽  
Innocent N. Njah ◽  
Offiong E. Offiong ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Antifungal Activity ◽  
Antihypertensive Drug ◽  
Hydralazine Hydrochloride

scholarly journals Calixarene-mediated assembly of a small antifungal protein

IUCrJ ◽  
2019 ◽  
Vol 6 (2) ◽  
pp. 238-247 ◽  
Author(s):  
Jimi M. Alex ◽  
Martin L. Rennie ◽  
Sylvain Engilberge ◽  
Gábor Lehoczki ◽  
Hajdu Dorottya ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Antifungal Activity ◽  
High Resolution ◽  
Complex Formation ◽  
Binding Site ◽  
Crystal Structures ◽  
Protein Assembly ◽  
Bidentate Ligand ◽  
Antifungal Protein ◽  
Protein Recognition

Synthetic macrocycles such as calixarenes and cucurbiturils are increasingly applied as mediators of protein assembly and crystallization. The macrocycle can facilitate assembly by providing a surface on which two or more proteins bind simultaneously. This work explores the capacity of the sulfonato-calix[n]arene (sclx n ) series to effect crystallization of PAF, a small, cationic antifungal protein. Co-crystallization with sclx4, sclx6 or sclx8 led to high-resolution crystal structures. In the absence of sclx n , diffraction-quality crystals of PAF were not obtained. Interestingly, all three sclx n were bound to a similar patch on PAF. The largest and most flexible variant, sclx8, yielded a dimer of PAF. Complex formation was evident in solution via NMR and ITC experiments, showing more pronounced effects with increasing macrocycle size. In agreement with the crystal structure, the ITC data suggested that sclx8 acts as a bidentate ligand. The contributions of calixarene size/conformation to protein recognition and assembly are discussed. Finally, it is suggested that the conserved binding site for anionic calixarenes implicates this region of PAF in membrane binding, which is a prerequisite for antifungal activity.

scholarly journals Production in Pichia pastoris, antifungal activity and crystal structure of a class I chitinase from cowpea (Vigna unguiculata): Insights into sugar binding mode and hydrolytic action

Biochimie ◽  
2017 ◽  
Vol 135 ◽  
pp. 89-103 ◽  
Author(s):  
Patrícia G. Castro Landim ◽  
Tuana O. Correia ◽  
Fredy D.A. Silva ◽  
Denise R. Nepomuceno ◽  
Helen P.S. Costa ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Antifungal Activity ◽  
Pichia Pastoris ◽  
Vigna Unguiculata ◽  
Binding Mode ◽  
Class I ◽  
Sugar Binding

Synthesis, crystal structure, characterization and antifungal activity of pyrazolo[1,5-a]pyrimidines derivatives

2016 ◽  
Vol 1120 ◽  
pp. 228-233 ◽  
Author(s):  
Jin Zhang ◽  
Ju-Fang Peng ◽  
Tao Wang ◽  
Ping Wang ◽  
Zun-Ting Zhang
Keyword(s):  
Crystal Structure ◽  
Antifungal Activity ◽  
Structure Characterization

scholarly journals Synthesis, Characterisation and Antifungal Activities of Some New Copper(II) Complexes of Isomeric 3,5,7,7,10,12,14,14-Octamethyl-1,4,8,11-Tetraazacyclotetradecanes

1997 ◽  
Vol 4 (5) ◽  
pp. 255-265 ◽  
Author(s):  
Saroj K. S. Hazari ◽  
Tapashi G. Roy ◽  
Benu K. Dey ◽  
Suvash C. Das ◽  
Edward R. T. Tiekink
Keyword(s):  
Crystal Structure ◽  
Antifungal Activity ◽  
Phytopathogenic Fungi ◽  
Antifungal Activities ◽  
X Ray ◽  
Conductance Data

Three isomeric Me8[14]anes, LA, LB and LC, undergo complexation with copper(II) salts to form a series of [CuLXn(H2O)x]Xy.(H2O)z complexes where L = LA, LB and LC; X = Cl, Br, NO3; n, x, y and z may have values of 0, 1 or 2. The complexes have been characterised on the basis of analytical, spectroscopic, magnetic and conductance data. Further, the X-ray crystal structure of one complex, [CuLB(OH2)2](NO3)2, has been determined. The antifungal activity of all three isomeric ligands and their complexes has been investigated against a range of phytopathogenic fungi.

scholarly journals Syntheses, crystal structure, spectroscopic characterization and antifungal activity of new N-R-sulfonyldithiocarbimate metal complexes

2009 ◽  
Vol 103 (7) ◽  
pp. 1045-1053 ◽  
Author(s):  
Leandro C. Alves ◽  
Mayura M.M. Rubinger ◽  
Renata H. Lindemann ◽  
Genivaldo J. Perpétuo ◽  
Jan Janczak ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Antifungal Activity ◽  
Metal Complexes ◽  
Spectroscopic Characterization

scholarly journals Synthesis, crystal structure and antifungal activity of dihydroisoquinoline Oxaziridines Substitued in Position 1

2014 ◽  
Vol 10 (4) ◽  
pp. 2551-2557 ◽  
Author(s):  
Mouna Bouzid ◽  
Raed Abdennabi ◽  
Chakib Hrizi ◽  
Neji Gharsallah ◽  
Majed Kammoun
Keyword(s):  
Crystal Structure ◽  
Antifungal Activity ◽  
Nitro Group ◽  
Oxidizing Agent ◽  
X Ray ◽  
X Ray Crystallography

We report here the synthesis and the X-ray crystallography of dihydroisoquinoline oxaziridines with methyl substitute in position 1 and with nitro group in position 7 (compound 3b). We also synthesized the compound 3a without nitro. These compounds have been prepared by the peracidic oxidation of imines with m-chloroperbenzoic (m-CPBA) like oxidizing agent. This two compounds exhibit higher antifungal activity.

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