Precise preparation of four-arm-poly(ethylene glycol)-block-poly(trimethylene carbonate) star block copolymers via activated monomer mechanism and examination of their solution properties

Polymer ◽  
2008 ◽  
Vol 49 (7) ◽  
pp. 1777-1782 ◽  
Author(s):  
Jae Song Cho ◽  
Byung Soo Kim ◽  
Hoon Hyun ◽  
Ju Yong Youn ◽  
Moon Suk Kim ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Ethylene Glycol ◽  
Solution Properties ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
Star Block Copolymers ◽  
Poly Ethylene

Comparison of micelles formed by amphiphilic poly(ethylene glycol)-b-poly(trimethylene carbonate) star block copolymers

2009 ◽  
Vol 111 (4) ◽  
pp. 1706-1712 ◽  
Author(s):  
Byung Soo Kim ◽  
Jae Min Oh ◽  
Jae Song Cho ◽  
Sang Hyo Lee ◽  
Bong Lee ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Ethylene Glycol ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
Star Block Copolymers ◽  
Poly Ethylene

Novel synthesis of biodegradable amphiphilic linear and star block copolymers based on poly(ɛ-caprolactone) and poly(ethylene glycol)

2007 ◽  
Vol 45 (17) ◽  
pp. 3975-3985 ◽  
Author(s):  
Yahia Lemmouchi ◽  
Michael C. Perry ◽  
Allan J. Amass ◽  
Khirud Chakraborty ◽  
Etienne Schacht
Keyword(s):  
Block Copolymers ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Novel Synthesis ◽  
Star Block Copolymers ◽  
Poly Ethylene

Iron Tris(bipyridine)-Centered Poly(ethylene glycol)-Poly(lactic acid) Star Block Copolymers

2008 ◽  
Vol 41 (23) ◽  
pp. 9397-9405 ◽  
Author(s):  
Gina L. Fiore ◽  
Jessica L. Klinkenberg ◽  
Cassandra L. Fraser
Keyword(s):  
Lactic Acid ◽  
Block Copolymers ◽  
Ethylene Glycol ◽  
Poly Lactic Acid ◽  
Poly Ethylene Glycol ◽  
Star Block Copolymers ◽  
Poly Ethylene

Synthesis and self-assembly of amphiphilic star-block copolymers consisting of polyethylene and poly(ethylene glycol) segments

2013 ◽  
Vol 129 (4) ◽  
pp. 2216-2223 ◽  
Author(s):  
Ran Liu ◽  
Zhi Yun Li ◽  
Wan Juan Wang ◽  
Dan Yuan ◽  
Chun Feng Meng ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Ethylene Glycol ◽  
Self Assembly ◽  
Poly Ethylene Glycol ◽  
Star Block Copolymers ◽  
Poly Ethylene

scholarly journals Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Copolymers for the Formulation of In Situ Forming Depot Long-Acting Injectables

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 605
Author(s):  
Marie-Emérentienne Cagnon ◽  
Silvio Curia ◽  
Juliette Serindoux ◽  
Jean-Manuel Cros ◽  
Feifei Ng ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Surface Erosion ◽  
Sustained Delivery ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
In Situ Forming ◽  
Poly Ethylene ◽  
Long Acting

This article describes the utilization of (methoxy)poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) ((m)PEG–PTMC) diblock and triblock copolymers for the formulation of in situ forming depot long-acting injectables by solvent exchange. The results shown in this manuscript demonstrate that it is possible to achieve long-term drug deliveries from suspension formulations prepared with these copolymers, with release durations up to several months in vitro. The utilization of copolymers with different PEG and PTMC molecular weights affords to modulate the release profile and duration. A pharmacokinetic study in rats with meloxicam confirmed the feasibility of achieving at least 28 days of sustained delivery by using this technology while showing good local tolerability in the subcutaneous environment. The characterization of the depots at the end of the in vivo study suggests that the rapid phase exchange upon administration and the surface erosion of the resulting depots are driving the delivery kinetics from suspension formulations. Due to the widely accepted utilization of meloxicam as an analgesic drug for animal care, the results shown in this article are of special interest for the development of veterinary products aiming at a very long-term sustained delivery of this therapeutic molecule.

scholarly journals Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Amphiphilic Copolymers for Long-Acting Injectables: Synthesis, Non-Acylating Performance and In Vivo Degradation

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1438
Author(s):  
Silvio Curia ◽  
Feifei Ng ◽  
Marie-Emérentienne Cagnon ◽  
Victor Nicoulin ◽  
Adolfo Lopez-Noriega
Keyword(s):  
Ethylene Glycol ◽  
Ring Opening ◽  
Gel Chromatography ◽  
Amphiphilic Copolymers ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Long Acting ◽  
In Vivo Degradation

This article presents the evaluation of diblock and triblock poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) amphiphilic copolymers (PEG-PTMCs) as excipients for the formulation of long-acting injectables (LAIs). Copolymers were successfully synthesised through bulk ring-opening polymerisation. The concomitant formation of PTMC homopolymer could not be avoided irrespective of the catalyst amount, but the by-product could easily be removed by gel chromatography. Pure PEG-PTMCs undergo faster erosion in vivo than their corresponding homopolymer. Furthermore, these copolymers show outstanding stability compared to their polyester analogues when formulated with amine-containing reactive drugs, which makes them particularly suitable as LAIs for the sustained release of drugs susceptible to acylation.

scholarly journals Intracellular Trafficking of Polyamidoamine–Poly(ethylene glycol) Block Copolymers in DNA Delivery

2011 ◽  
Vol 22 (8) ◽  
pp. 1519-1525 ◽  
Author(s):  
Daniel K. Bonner ◽  
Cheuk Leung ◽  
Jane Chen-Liang ◽  
Loice Chingozha ◽  
Robert Langer ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Ethylene Glycol ◽  
Intracellular Trafficking ◽  
Dna Delivery ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene
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