Effect of polymer degradation on prolonged release of paclitaxel from filomicelles of polylactide/poly(ethylene glycol) block copolymers

2017 ◽  
Vol 75 ◽  
pp. 918-925 ◽  
Author(s):  
Katarzyna Jelonek ◽  
Suming Li ◽  
Janusz Kasperczyk ◽  
Xiaohan Wu ◽  
Arkadiusz Orchel
Keyword(s):  
Block Copolymers ◽  
Ethylene Glycol ◽  
Polymer Degradation ◽  
Prolonged Release ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

scholarly journals Tailoring Atomoxetine Release Rate from DLP 3D-Printed Tablets Using Artificial Neural Networks: Influence of Tablet Thickness and Drug Loading

Molecules ◽  
2020 ◽  
Vol 26 (1) ◽  
pp. 111
Author(s):  
Gordana Stanojević ◽  
Djordje Medarević ◽  
Ivana Adamov ◽  
Nikola Pešić ◽  
Jovana Kovačević ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Release Rate ◽  
Drug Loading ◽  
Prolonged Release ◽  
Cylindrical Shape ◽  
Poly Ethylene Glycol ◽  
Scanning Calorimetry ◽  
3D Printed ◽  
Artificial Neural ◽  
Poly Ethylene

Various three-dimensional printing (3DP) technologies have been investigated so far in relation to their potential to produce customizable medicines and medical devices. The aim of this study was to examine the possibility of tailoring drug release rates from immediate to prolonged release by varying the tablet thickness and the drug loading, as well as to develop artificial neural network (ANN) predictive models for atomoxetine (ATH) release rate from DLP 3D-printed tablets. Photoreactive mixtures were comprised of poly(ethylene glycol) diacrylate (PEGDA) and poly(ethylene glycol) 400 in a constant ratio of 3:1, water, photoinitiator and ATH as a model drug whose content was varied from 5% to 20% (w/w). Designed 3D models of cylindrical shape tablets were of constant diameter, but different thickness. A series of tablets with doses ranging from 2.06 mg to 37.48 mg, exhibiting immediate- and modified-release profiles were successfully fabricated, confirming the potential of this technology in manufacturing dosage forms on demand, with the possibility to adjust the dose and release behavior by varying drug loading and dimensions of tablets. DSC (differential scanning calorimetry), XRPD (X-ray powder diffraction) and microscopic analysis showed that ATH remained in a crystalline form in tablets, while FTIR spectroscopy confirmed that no interactions occurred between ATH and polymers.

scholarly journals Intracellular Trafficking of Polyamidoamine–Poly(ethylene glycol) Block Copolymers in DNA Delivery

2011 ◽  
Vol 22 (8) ◽  
pp. 1519-1525 ◽  
Author(s):  
Daniel K. Bonner ◽  
Cheuk Leung ◽  
Jane Chen-Liang ◽  
Loice Chingozha ◽  
Robert Langer ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Ethylene Glycol ◽  
Intracellular Trafficking ◽  
Dna Delivery ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

In vivo and in vitro degradation of poly(ether ester) block copolymers based on poly(ethylene glycol) and poly(butylene terephthalate)

Biomaterials ◽  
2004 ◽  
Vol 25 (2) ◽  
pp. 247-258 ◽  
Author(s):  
A.A. Deschamps ◽  
A.A. van Apeldoorn ◽  
H. Hayen ◽  
J.D. de Bruijn ◽  
U. Karst ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
In Vitro Degradation ◽  
Butylene Terephthalate ◽  
Poly Ethylene ◽  
Ether Ester

Micellar carriers based on block copolymers of poly(ε-caprolactone) and poly(ethylene glycol) for doxorubicin delivery

2004 ◽  
Vol 98 (3) ◽  
pp. 415-426 ◽  
Author(s):  
Xintao Shuai ◽  
Hua Ai ◽  
Norased Nasongkla ◽  
Saejeong Kim ◽  
Jinming Gao
Keyword(s):  
Block Copolymers ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Doxorubicin Delivery ◽  
Poly Ethylene

Synthesis, characterization and cytotoxicity of poly(ethylene glycol)-graft-trimethyl chitosan block copolymers

Biomaterials ◽  
2005 ◽  
Vol 26 (32) ◽  
pp. 6343-6356 ◽  
Author(s):  
S MAO ◽  
X SHUAI ◽  
F UNGER ◽  
M WITTMAR ◽  
X XIE ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Trimethyl Chitosan ◽  
Poly Ethylene
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