PP116. Circulating PlGF can help predict preeclampsia and adverse outcome in patients with suspected preeclampsia or fetal growth restriction

With the ascendancy of biophysical assessment with Doppler velocimetry, and the establishment of routine scan dating in early pregnancy, there needs to be a radical re-think of the role of ultrasound biometry in the definition and assessment of fetal growth restriction (FGR).Doppler flow velocimetry of the umbilical artery has proven its value in defining the FGR fetus. It is more useful than cardiotocography (CTG) or biophysical profile scoring. However, the sensitivity of any test depends on the prevalence of the condition being looked for. While Doppler is of value in fetuses which are small-for-gestational age (SGA), it is less useful in predicting growth restriction or adverse outcome in the general population. The question is therefore, how to detect those pregnancies for which further fetal assessment is indicated.

Download Full-text

Fetal hemodynamics and adverse outcome in primary school-aged children with fetal growth restriction: a prospective longitudinal study

Acta Obstetricia Et Gynecologica Scandinavica ◽

10.1111/aogs.13052 ◽

2016 ◽

Vol 96 (1) ◽

pp. 69-77 ◽

Cited By ~ 8

Author(s):

Noora Korkalainen ◽

Juha Räsänen ◽

Tuula Kaukola ◽

Hanna Kallankari ◽

Mikko Hallman ◽

...

Keyword(s):

Longitudinal Study ◽

Primary School ◽

Fetal Growth ◽

Fetal Growth Restriction ◽

Adverse Outcome ◽

Growth Restriction ◽

Prospective Longitudinal Study ◽

School Aged Children ◽

Prospective Longitudinal

Download Full-text

Adverse outcome in monochorionic twins with selective intrauterine fetal growth restriction in the presence of abnormal umbilical artery Doppler and severe oligohydramnios

Journal of Obstetrics and Gynaecology Research ◽

10.1111/j.1447-0756.2012.01940.x ◽

2012 ◽

Vol 38 (10) ◽

pp. 1271-1271 ◽

Cited By ~ 6

Author(s):

Keisuke Ishii ◽

Takeshi Murakoshi ◽

Haruhiko Sago

Keyword(s):

Fetal Growth ◽

Fetal Growth Restriction ◽

Umbilical Artery ◽

Adverse Outcome ◽

Growth Restriction ◽

Monochorionic Twins ◽

Umbilical Artery Doppler ◽

Intrauterine Fetal Growth Restriction

Download Full-text

Longitudinal Doppler Assessments in Late Preterm Fetal Growth Restriction

Ultraschall in der Medizin - European Journal of Ultrasound ◽

10.1055/a-1511-8293 ◽

2021 ◽

Author(s):

Bronacha Mylrea-Foley ◽

Hans Wolf ◽

Tamara Stampalija ◽

Christoph Lees ◽

B. Arabin ◽

...

Keyword(s):

Fetal Growth ◽

Fetal Growth Restriction ◽

Adverse Outcome ◽

Repeated Measurements ◽

Growth Restriction ◽

Late Preterm ◽

Abdominal Circumference ◽

Singleton Pregnancy ◽

Measurement Interval ◽

Multicenter Observational Study

Abstract Purpose To assess the longitudinal variation of the ratio of umbilical and cerebral artery pulsatility index (UCR) in late preterm fetal growth restriction (FGR). Materials and Methods A prospective European multicenter observational study included women with a singleton pregnancy, 32+ 0–36+ 6, at risk of FGR (estimated fetal weight [EFW] or abdominal circumference [AC] < 10th percentile, abnormal arterial Doppler or fall in AC from 20-week scan of > 40 percentile points). The primary outcome was a composite of abnormal condition at birth or major neonatal morbidity. UCR was categorized as normal (< 0.9) or abnormal (≥ 0.9). UCR was assessed by gestational age at measurement interval to delivery, and by individual linear regression coefficient in women with two or more measurements. Results 856 women had 2770 measurements; 696 (81 %) had more than one measurement (median 3 (IQR 2–4). At inclusion, 63 (7 %) a UCR ≥ 0.9. These delivered earlier and had a lower birth weight and higher incidence of adverse outcome (30 % vs. 9 %, relative risk 3.2; 95 %CI 2.1–5.0) than women with a normal UCR at inclusion. Repeated measurements after an abnormal UCR at inclusion were abnormal again in 67 % (95 %CI 55–80), but after a normal UCR the chance of finding an abnormal UCR was 6 % (95 %CI 5–7 %). The risk of composite adverse outcome was similar using the first or subsequent UCR values. Conclusion An abnormal UCR is likely to be abnormal again at a later measurement, while after a normal UCR the chance of an abnormal UCR is 5–7 % when repeated weekly. Repeated measurements do not predict outcome better than the first measurement, most likely due to the most compromised fetuses being delivered after an abnormal UCR.

Download Full-text