Oral treatment of rodents with soluble epoxide hydrolase inhibitor 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea (TPPU): Resulting drug levels and modulation of oxylipin pattern

Drug Levels ◽

Soluble epoxide hydrolase inhibitor trifluoromethoxyphenyl‐3‐(1‐propionylpiperidin‐4‐yl)urea prevents hyperalgesia through regulating NLRC4 inflammasome‐related pro‐inflammatory and anti‐inflammatory signaling pathways in the lipopolysaccharide‐induced pain mouse model

Drug Development Research ◽

10.1002/ddr.21786 ◽

2021 ◽

Author(s):

Ali Cagli ◽

Sefika Pinar Senol ◽

Meryem Temiz‐Resitoglu ◽

Demet Sinem Guden ◽

Ayse Nihal Sari ◽

...

Keyword(s):

Mouse Model ◽

Signaling Pathways ◽

Epoxide Hydrolase ◽

Inflammatory Signaling ◽

Soluble Epoxide Hydrolase Inhibitor ◽

Anti Inflammatory

THE ROLE OF EPOXYEICOSATRIENOIC ACIDS IN REGULATING ENDOTHELIAL FUNCTION AND THE EFFECTS OF A NOVEL SOLUBLE EPOXIDE HYDROLASE INHIBITOR GSK2256294 IN HUMANS

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(16)32309-9 ◽

2016 ◽

Vol 67 (13) ◽

pp. 2308

Author(s):

Lucy Yang ◽

Joseph Cheriyan ◽

Aili Lazaar ◽

Kaisa Maki-Petaja ◽

Ian Wilkinson

Keyword(s):

Endothelial Function ◽

Epoxide Hydrolase ◽

Epoxyeicosatrienoic Acids ◽

Soluble epoxide hydrolase inhibitor, TUPS, attenuates isoproterenol/angiotensin II‐induced cardiac hypertrophy through mammalian target of rapamycin‐mediated autophagy inhibition

Journal of Pharmacy and Pharmacology ◽

10.1111/jphp.13113 ◽

2019 ◽

Vol 71 (8) ◽

pp. 1291-1300 ◽

Cited By ~ 3

Author(s):

Huanji Zhang ◽

Kun Zhang ◽

Jianwen Liang ◽

Wen Yan ◽

Fensheng Wu ◽

...

Keyword(s):

Angiotensin Ii ◽

Cardiac Hypertrophy ◽

Epoxide Hydrolase ◽

Mammalian Target Of Rapamycin ◽

Target Of Rapamycin ◽

Soluble Epoxide Hydrolase Inhibitor ◽

Autophagy Inhibition

Soluble Epoxide Hydrolase Inhibitor Attenuates Lipopolysaccharide-Induced Acute Lung Injury and Improves Survival in Mice

Shock ◽

10.1097/shk.0000000000000767 ◽

2017 ◽

Vol 47 (5) ◽

pp. 638-645 ◽

Cited By ~ 39

Author(s):

Yong Zhou ◽

Tian Liu ◽

Jia-Xi Duan ◽

Ping Li ◽

Guo-Ying Sun ◽

...

Keyword(s):

Acute Lung Injury ◽

Lung Injury ◽

Epoxide Hydrolase ◽

Reduced coronary reactive hyperemia in mice was reversed by the soluble epoxide hydrolase inhibitor ( t -AUCB): Role of adenosine A 2A receptor and plasma oxylipins

Prostaglandins & Other Lipid Mediators ◽

10.1016/j.prostaglandins.2017.09.001 ◽

2017 ◽

Vol 131 ◽

pp. 83-95 ◽

Cited By ~ 3

Author(s):

Ahmad Hanif ◽

Matthew L. Edin ◽

Darryl C. Zeldin ◽

Christophe Morisseau ◽

John R. Falck ◽

...

Keyword(s):

Epoxide Hydrolase ◽

Reactive Hyperemia ◽

Differential Effects of Combined Soluble Epoxide Hydrolase inhibitor t ‐TUCB and n‐3 Epoxide in Diet‐Induced Obesity

The FASEB Journal ◽

10.1096/fasebj.2021.35.s1.04632 ◽

2021 ◽

Vol 35 (S1) ◽

Author(s):

Yang Yang ◽

Xinyun Xu ◽

Christophe Morisseau ◽

Bruce Hammock ◽

Ahmed Bettaieb ◽

...

Keyword(s):

Epoxide Hydrolase ◽

Differential Effects ◽

Diet Induced Obesity ◽

Effect of a Soluble Epoxide Hydrolase Inhibitor, UC1728, on LPS-Induced Uveitis in the Rabbit

Journal of Ocular Biology ◽

10.13188/2334-2838.1000024 ◽

2016 ◽

Vol 4 (1) ◽

Cited By ~ 2

Keyword(s):

Epoxide Hydrolase ◽

The soluble epoxide hydrolase inhibitor GSK2256294 decreases the proportion of adipose pro-inflammatory T cells

Prostaglandins & Other Lipid Mediators ◽

10.1016/j.prostaglandins.2021.106604 ◽

2021 ◽

pp. 106604

Author(s):

Mona Mashayekhi ◽

Celestine N. Wanjalla ◽

Christian M. Warren ◽

Joshua D. Simmons ◽

Kakali Ghoshal ◽

...

Keyword(s):

T Cells ◽

Epoxide Hydrolase ◽

Isolation of soluble epoxide hydrolase inhibitor of capsaicin analogs from Capsicum chinense Jacq. cv. Habanero

International Journal of Biological Macromolecules ◽

10.1016/j.ijbiomac.2019.06.028 ◽

2019 ◽

Vol 135 ◽

pp. 1202-1207 ◽

Cited By ~ 7

Author(s):

Jang Hoon Kim ◽

Yeong Deuk Jo ◽

Chang Hyun Jin

Keyword(s):

Epoxide Hydrolase ◽

Capsicum Chinense ◽

Abstract LB-299: Enhanced inhibitory effects on mutant KrasG12D-initiated murine pancreatic carcinoma growth in Fat-1 transgenic mice treated with soluble epoxide hydrolase inhibitor t-AUCB

10.1158/1538-7445.am2016-lb-299 ◽

2016 ◽

Author(s):

Jie Liao ◽

Rong Xia ◽

Jun Yang ◽

Haonan Li ◽

Dandan Xu ◽

...

Keyword(s):

Transgenic Mice ◽

Pancreatic Carcinoma ◽

Epoxide Hydrolase ◽

Inhibitory Effects ◽