A novel digital health intervention to improve patient engagement to stimulants in adult ADHD in the primary care setting: Preliminary findings from an open label study

2020 ◽  
Vol 291 ◽  
pp. 113158
Author(s):  
Joseph Biederman ◽  
Ronna Fried ◽  
Maura DiSalvo ◽  
Haley Driscoll ◽  
Allison Green ◽  
...  
2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Jonathan Dutt ◽  
Pooja Sheth-Dutt ◽  
Michal Dynda

2019 ◽  
Vol 34 (10) ◽  
pp. 1971-1972 ◽  
Author(s):  
Richard SoRelle ◽  
Judy A. Shea ◽  
Becky Shasha ◽  
Shimrit Keddem ◽  
Judith A. Long ◽  
...  

2020 ◽  
pp. 108705471989685
Author(s):  
Margaret D. Weiss ◽  
Ann C. Childress ◽  
Graeme A.E. Donnelly

Objective: To evaluate the efficacy and safety of a 16-hr multilayer-release methylphenidate (PRC-063) in a community-based adult ADHD population. Method: In a double-blind study, 375 participants were randomized to one of four fixed doses of PRC-063 or placebo. The primary outcome was the ADHD-Rating Scale-5 (RS). The first 50% of double-blind completers were invited to participate in a 6-month dose-optimized open-label study to assess response and safety. Results: In total, 333 participants completed the double-blind trial; 184 entered the open-label study. PRC-063 produced greater symptom reduction in ADHD-RS-5 total score from baseline compared with placebo in the double-blind study (least-square [LS] mean = −4.7 [−7.7, −1.6], p = .003). The most frequent adverse events were headache, insomnia, and decreased appetite. No significant sleep quality impact was observed ( p = .123). Significant improvements in ADHD-RS-5 scores from baseline continued through the open-label study ( p < .0001), coincident with dose optimization. Conclusion: PRC-063 was well tolerated and significantly improved ADHD symptomatology in adults.


2018 ◽  
Vol 24 (6) ◽  
pp. 293-303 ◽  
Author(s):  
Philippe Castera ◽  
Edmund Stewart ◽  
Josef Großkopf ◽  
Carlos Brotons ◽  
Maiken Brix Schou ◽  
...  

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