Cannabis use and clinical outcome in people with first-episode schizophrenia spectrum disorders over 24 months of treatment

Abstract Background In this study, we explored the relationship between hippocampal subfield volumes and change in body mass over 12 months of treatment in 90 first-episode schizophrenia spectrum disorder patients (66 males, 24 females; mean age= 24.7±6.8 years). Methods Body mass index was assessed in patients at baseline, and at months 3, 6, 9 and 12. Hippocampal subfields of interest were assessed using a segmentation algorithm included in the FreeSurfer 6.0 software program. Results Linear regression analysis showed a significant interactive effect between sex and anterior hippocampus size as a predictor of change in body mass over 12 months, adjusting for age, substance use, treatment duration, and posterior hippocampal volumes. In an exploratory sub-analysis, partial correlations revealed a significant association between weight gain and smaller CA1, CA3 and subiculum volumes in females, but not males, adjusting for age and substance use, with similar trends evident for the CA4 and presubiculum subfields. Discussion In conclusion, our findings suggest that smaller anterior hippocampal subfields are associated with the development of weight gain over the course of treatment in first-episode schizophrenia spectrum disorders in a sex-specific fashion, and may partly explain the more severe and ongoing increase in body mass evident for female patients.

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SA33. In-Between Cognitive Domains Correlations in First-Episode Schizophrenia Spectrum Disorders

Schizophrenia Bulletin ◽

10.1093/schbul/sbx023.032 ◽

2017 ◽

Vol 43 (suppl_1) ◽

pp. S125-S125

Author(s):

Mabel Virginia Rodriguez Manchola ◽

Zuzana Kratochvilova

Keyword(s):

First Episode ◽

Schizophrenia Spectrum Disorders ◽

Cognitive Domains ◽

Schizophrenia Spectrum ◽

Spectrum Disorders ◽

First Episode Schizophrenia

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Depressive psychopathology in first-episode schizophrenia spectrum disorders: a systematic review, meta-analysis and meta-regression

Psychological Medicine ◽

10.1017/s0033291719002344 ◽

2019 ◽

Vol 49 (15) ◽

pp. 2463-2474 ◽

Cited By ~ 5

Author(s):

Sarah E. Herniman ◽

Kelly Allott ◽

Lisa J. Phillips ◽

Stephen J. Wood ◽

Jacqueline Uren ◽

...

Keyword(s):

Systematic Review ◽

Depressive Disorder ◽

Meta Analysis ◽

First Episode ◽

Schizophrenia Spectrum Disorders ◽

Schizophrenia Spectrum ◽

Pooled Prevalence ◽

Meta Regression ◽

Spectrum Disorders ◽

First Episode Schizophrenia

AbstractBackgroundDespite knowing for many decades that depressive psychopathology is common in first-episode schizophrenia spectrum disorders (FES), there is limited knowledge regarding the extent and nature of such psychopathology (degree of comorbidity, caseness, severity) and its demographic, clinical, functional and treatment correlates. This study aimed to determine the pooled prevalence of depressive disorder and caseness, and the pooled mean severity of depressive symptoms, as well as the demographic, illness, functional and treatment correlates of depressive psychopathology in FES.MethodsThis systematic review, meta-analysis and meta-regression was prospectively registered (CRD42018084856) and conducted in accordance with PRISMA and MOOSE guidelines.ResultsForty studies comprising 4041 participants were included. The pooled prevalence of depressive disorder and caseness was 26.0% (seven samples, N = 855, 95% CI 22.1–30.3) and 43.9% (11 samples, N = 1312, 95% CI 30.3–58.4), respectively. The pooled mean percentage of maximum depressive symptom severity was 25.1 (38 samples, N = 3180, 95% CI 21.49–28.68). Correlates of depressive psychopathology were also found.ConclusionsAt least one-quarter of individuals with FES will experience, and therefore require treatment for, a full-threshold depressive disorder. Nearly half will experience levels of depressive symptoms that are severe enough to warrant diagnostic investigation and therefore clinical intervention – regardless of whether they actually fulfil diagnostic criteria for a depressive disorder. Depressive psychopathology is prominent in FES, manifesting not only as superimposed comorbidity, but also as an inextricable symptom domain.

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Substance abuse and first-episode schizophrenia-spectrum disorders. The Danish OPUS trial

Early Intervention in Psychiatry ◽

10.1111/j.1751-7893.2007.00015.x ◽

2007 ◽

Vol 1 (1) ◽

pp. 88-96 ◽

Cited By ~ 26

Author(s):

Lone Petersen ◽

Pia Jeppesen ◽

Anne Thorup ◽

Johan Øhlenschlæger ◽

Gertrud Krarup ◽

...

Keyword(s):

Substance Abuse ◽

First Episode ◽

Schizophrenia Spectrum Disorders ◽

Schizophrenia Spectrum ◽

Spectrum Disorders ◽

First Episode Schizophrenia

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Deinstitutionalization revisited: a 5-year follow-up of a randomized clinical trial of hospital-based rehabilitation versus specialized assertive intervention (OPUS) versus standard treatment for patients with first-episode schizophrenia spectrum disorders

Psychological Medicine ◽

10.1017/s0033291709992182 ◽

2010 ◽

Vol 40 (10) ◽

pp. 1619-1626 ◽

Cited By ~ 16

Author(s):

M. Nordentoft ◽

J. Øhlenschlæger ◽

A. Thorup ◽

L. Petersen ◽

Pia Jeppesen ◽

...

Keyword(s):

Standard Treatment ◽

Supported Housing ◽

First Episode ◽

Schizophrenia Spectrum Disorders ◽

Schizophrenia Spectrum ◽

Episode Psychosis ◽

Bed Days ◽

Spectrum Disorders ◽

First Episode Schizophrenia

BackgroundThe effects of hospital-based rehabilitation including weekly supportive psychodynamic therapy compared with specialized assertive intervention and standard treatment has not previously been investigated in first-episode psychosis. The aim of the study was to examine long-term effect on use of institutional care of different intensive interventions for patients with first-episode schizophrenia spectrum disorder on use of psychiatric bed days and days in supported housing.MethodA total of 94 severely ill patients with first-episode schizophrenia spectrum disorders were included in a special part of the Copenhagen OPUS trial and randomized to either the specialized assertive intervention program (OPUS), standard treatment or hospital-based rehabilitation.ResultsIt was a stable pattern that patients randomized to hospital-based rehabilitation spent more days in psychiatric wards and in supported housing throughout the 5-year follow-up period compared with the two other groups. Patients in OPUS treatment spent significantly fewer days in psychiatric wards and supported housing in the first 3 years compared with patients in hospital-based rehabilitation. Due to attrition and small sample size, differences in level of psychotic and negative symptoms at 5-year follow-up could not be evaluated.ConclusionsThe study indicates that hospital-based rehabilitation together with weekly supportive psychodynamic therapy was associated with a continued increased use of psychiatric bed days and days in supported housing. The data cannot justify using hospital-based rehabilitation in first-episode psychosis.

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