scholarly journals Drug‐naïve first‐episode schizophrenia spectrum disorders: Pharmacological treatment practices in inpatient units in Hunan Province, China

2020 ◽  
Author(s):  
Mengran Zhu ◽  
Maria Ferrara ◽  
Wenjian Tan ◽  
Xingbo Shang ◽  
Sumaiyah Syed ◽  
...  
Keyword(s):  
Pharmacological Treatment ◽  
Hunan Province ◽  
First Episode ◽  
Schizophrenia Spectrum Disorders ◽  
Treatment Practices ◽  
Schizophrenia Spectrum ◽  
Drug Naïve ◽  
Spectrum Disorders ◽  
First Episode Schizophrenia ◽  
Inpatient Units

Body mass index (BMI) of drug-naïve psychotic adolescents based on a population of adolescent psychiatric inpatients

2008 ◽  
Vol 23 (7) ◽  
pp. 521-526 ◽  
Author(s):  
Jaana Juutinen ◽  
Helinä Hakko ◽  
V. Benno Meyer-Rochow ◽  
Pirkko Räsänen ◽  
Markku Timonen ◽  
...  
Keyword(s):  
Psychiatric Inpatient ◽  
Psychiatric Inpatients ◽  
Adolescent Male ◽  
First Episode ◽  
Schizophrenia Spectrum Disorders ◽  
Adolescent Boys ◽  
Schizophrenia Spectrum ◽  
Drug Naïve ◽  
Spectrum Disorders ◽  
First Episode Schizophrenia

AbstractObjectiveTo investigate the connection between overweight and first-episode schizophrenia spectrum as well as non-schizophrenia spectrum psychiatric disorders in adolescent male and female drug-naïve psychiatric inpatients, whose illness was early onset.MethodThree hundred twenty-three adolescents with no past or present psychiatric medication, 12–17 years of age, admitted to the psychiatric inpatient care (Oulu University Hospital, Northern Finland) between April 2001 and March 2006. DSM-IV diagnoses were based on the “Schedule for Affective Disorder and Schizophrenia for School-Age Children Present and Lifetime” (K-SADS-PL). An adolescent was defined as overweight if his or her BMI was greater than or equal to the 85th percentile.ResultsOverweight values were highest in drug-naïve adolescent boys with first-episode schizophrenia spectrum (RR: 2.5, 95%CI: 1.08–4.29) and non-schizophrenia spectrum (RR: 2.80, 95%CI: 2.20–3.45) disorders. The RR in girls with non-schizophrenia spectrum disorders was 1.73 (95%CI: 1.31–2.23), but in those with first-episode schizophrenia spectrum disorders RR did not differ from general population.ConclusionsIn our study sample of first-episode schizophrenia spectrum drug-naïve adolescents, overweight was shown to be prevalent in all diagnostic groups other than first-episode schizophrenia spectrum psychotic girls. To the best of our knowledge, this is the first study in which overweight was analyzed and verified among drug-naïve adolescent boys, suffering from first-episode schizophrenia spectrum disorder. To what extent our results are applicable to other regions and study groups, remains to be seen.

scholarly journals S201. HIPPOCAMPAL SUBFIELD VOLUMES AND CHANGE IN BODY MASS OVER 12 MONTHS OF TREATMENT IN FIRST-EPISODE SCHIZOPHRENIA SPECTRUM DISORDERS

2020 ◽  
Vol 46 (Supplement_1) ◽  
pp. S114-S115
Author(s):  
Stéfan Du Plessis ◽  
Hilmar Luckhoff ◽  
Sanja Kilian ◽  
Laila Asmal ◽  
Frederika Scheffler ◽  
...  
Keyword(s):  
Substance Use ◽  
Weight Gain ◽  
Body Mass ◽  
Interactive Effect ◽  
First Episode ◽  
Schizophrenia Spectrum Disorders ◽  
Hippocampal Subfields ◽  
Schizophrenia Spectrum ◽  
Spectrum Disorders ◽  
First Episode Schizophrenia

Abstract Background In this study, we explored the relationship between hippocampal subfield volumes and change in body mass over 12 months of treatment in 90 first-episode schizophrenia spectrum disorder patients (66 males, 24 females; mean age= 24.7±6.8 years). Methods Body mass index was assessed in patients at baseline, and at months 3, 6, 9 and 12. Hippocampal subfields of interest were assessed using a segmentation algorithm included in the FreeSurfer 6.0 software program. Results Linear regression analysis showed a significant interactive effect between sex and anterior hippocampus size as a predictor of change in body mass over 12 months, adjusting for age, substance use, treatment duration, and posterior hippocampal volumes. In an exploratory sub-analysis, partial correlations revealed a significant association between weight gain and smaller CA1, CA3 and subiculum volumes in females, but not males, adjusting for age and substance use, with similar trends evident for the CA4 and presubiculum subfields. Discussion In conclusion, our findings suggest that smaller anterior hippocampal subfields are associated with the development of weight gain over the course of treatment in first-episode schizophrenia spectrum disorders in a sex-specific fashion, and may partly explain the more severe and ongoing increase in body mass evident for female patients.

Depressive psychopathology in first-episode schizophrenia spectrum disorders: a systematic review, meta-analysis and meta-regression

2019 ◽  
Vol 49 (15) ◽  
pp. 2463-2474 ◽  
Author(s):  
Sarah E. Herniman ◽  
Kelly Allott ◽  
Lisa J. Phillips ◽  
Stephen J. Wood ◽  
Jacqueline Uren ◽  
...  
Keyword(s):  
Systematic Review ◽  
Depressive Disorder ◽  
Meta Analysis ◽  
First Episode ◽  
Schizophrenia Spectrum Disorders ◽  
Schizophrenia Spectrum ◽  
Pooled Prevalence ◽  
Meta Regression ◽  
Spectrum Disorders ◽  
First Episode Schizophrenia

AbstractBackgroundDespite knowing for many decades that depressive psychopathology is common in first-episode schizophrenia spectrum disorders (FES), there is limited knowledge regarding the extent and nature of such psychopathology (degree of comorbidity, caseness, severity) and its demographic, clinical, functional and treatment correlates. This study aimed to determine the pooled prevalence of depressive disorder and caseness, and the pooled mean severity of depressive symptoms, as well as the demographic, illness, functional and treatment correlates of depressive psychopathology in FES.MethodsThis systematic review, meta-analysis and meta-regression was prospectively registered (CRD42018084856) and conducted in accordance with PRISMA and MOOSE guidelines.ResultsForty studies comprising 4041 participants were included. The pooled prevalence of depressive disorder and caseness was 26.0% (seven samples, N = 855, 95% CI 22.1–30.3) and 43.9% (11 samples, N = 1312, 95% CI 30.3–58.4), respectively. The pooled mean percentage of maximum depressive symptom severity was 25.1 (38 samples, N = 3180, 95% CI 21.49–28.68). Correlates of depressive psychopathology were also found.ConclusionsAt least one-quarter of individuals with FES will experience, and therefore require treatment for, a full-threshold depressive disorder. Nearly half will experience levels of depressive symptoms that are severe enough to warrant diagnostic investigation and therefore clinical intervention – regardless of whether they actually fulfil diagnostic criteria for a depressive disorder. Depressive psychopathology is prominent in FES, manifesting not only as superimposed comorbidity, but also as an inextricable symptom domain.

scholarly journals Substance abuse and first-episode schizophrenia-spectrum disorders. The Danish OPUS trial

2007 ◽  
Vol 1 (1) ◽  
pp. 88-96 ◽  
Author(s):  
Lone Petersen ◽  
Pia Jeppesen ◽  
Anne Thorup ◽  
Johan Øhlenschlæger ◽  
Gertrud Krarup ◽  
...  
Keyword(s):  
Substance Abuse ◽  
First Episode ◽  
Schizophrenia Spectrum Disorders ◽  
Schizophrenia Spectrum ◽  
Spectrum Disorders ◽  
First Episode Schizophrenia

Risk factors, pre-morbid functioning and episode correlates of neurological soft signs in drug-naive patients with schizophrenia-spectrum disorders

2010 ◽  
Vol 41 (6) ◽  
pp. 1279-1289 ◽  
Author(s):  
V. Peralta ◽  
E. G. de Jalón ◽  
M. S. Campos ◽  
V. Basterra ◽  
A. Sanchez-Torres ◽  
...  
Keyword(s):  
Risk Factors ◽  
Obstetric Complications ◽  
First Episode ◽  
Schizophrenia Spectrum Disorders ◽  
Neurodevelopmental Delay ◽  
Abnormal Movements ◽  
Schizophrenia Spectrum ◽  
Extrapyramidal Syndromes ◽  
Drug Naïve ◽  
Spectrum Disorders

BackgroundThere is a lack of consistent evidence regarding associations of neurological soft signs (NSS) with illness-related variables in schizophrenia. This study examined NSS in first-episode psychotic patients with respect to their factor structure and associations with risk factors, pre-morbid characteristics, psychopathology and spontaneous extrapyramidal syndromes.MethodFirst-episode, drug-naive patients with schizophrenia-spectrum disorders (n=177) were assessed for NSS using the Neurological Evaluation Scale, and its 26 constituting items were factor analysed. The identified neurological dimensions were then entered into hierarchical regression models as outcome dependent variables of a set of predictors including risk factors (familial loading for schizophrenia, obstetric complications), pre-morbid characteristics (neurodevelopmental delay, symptoms of attention deficit–hyperactivity disorder, pre-morbid functioning), psychopathological domains (reality distortion, disorganization, negative symptoms, mania, depression, catatonia) and spontaneous extrapyramidal syndromes (parkinsonism, dyskinesia, akathisia).ResultsFive neurological domains were identified: sequencing, release signs, sensory integration, abnormal movements and coordination. Multivariate analyses showed independent associations (p<0.01) of sequencing with familial liability to schizophrenia, deterioration of pre-morbid adjustment and parkinsonism; release signs with obstetric complications, catatonic symptoms and parkinsonism; sensory integration with familial liability to schizophrenia; abnormal movements with familial liability to schizophrenia, obstetric complications, parkinsonism and dyskinesia; and coordination with neurodevelopmental delay. The empirically derived factors explained additional variance over and above that explained by subscale scores across the examined variables.ConclusionsFamilial liability to schizophrenia, obstetric complications, neurodevelopmental delay, deterioration in pre-morbid functioning and observable motor disorders appear to contribute independently to domains of neurological dysfunction. The findings support a neurodevelopmental model of NSS in schizophrenia.

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