Colesevelam hydrochloride does not cause maternal or fetal toxicity in rats and rabbits

The maternal and developmental toxicity of combined exposure to restraint stress and caffeine was assessed in mice. On gestational Days 0–18, three groups of plug-positive females (n = 13–15) were given by gavage caffeine at 30, 60, and 120 mg/kg/day. Three additional groups received the same caffeine doses and were restrained for 2 hr/day. Control groups included restrained and unrestrained plug-positive mice not exposed to caffeine. All animals in the group concurrently exposed to 120 mg/kg/day of caffeine and restraint died during the experimental period. In the remaining groups, cesarean sections were performed on Day 18 of gestation, and the fetuses were weighed and examined for external, internal, and skeletal malformations and variations. Although maternal and embryo/fetal toxicity were observed at all caffeine doses, the adverse maternal and developmental effects were significantly enhanced in the groups concurrently exposed to caffeine and restraint. It was especially remarkable at 60 and 120 mg/kg/day. The results of this study suggest that maternal and developmental toxic effects might occur if high amounts of caffeine were consumed by women under a notable stress during pregnancy.

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Fundamentals of fetal toxicity relevant to sevoflurane exposures during pregnancy

International Journal of Developmental Neuroscience ◽

10.1016/j.ijdevneu.2018.11.001 ◽

2018 ◽

Vol 72 (1) ◽

pp. 31-35

Author(s):

Dongdong Chai ◽

Yanyong Cheng ◽

Hong Jiang

Keyword(s):

Fetal Toxicity ◽

Exposures During Pregnancy

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Drug Administration During Pregnancy–Evaluation of Fetal Toxicity

Paediatric Clinical Pharmacology ◽

10.1201/b14101-30 ◽

2006 ◽

pp. 291-298

Author(s):

Pierre Guittin

Keyword(s):

Drug Administration ◽

Fetal Toxicity

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Fetal toxicity associated with maternal carbon monoxide poisoning

Annals of Emergency Medicine ◽

10.1016/s0196-0644(88)80619-x ◽

1988 ◽

Vol 17 (7) ◽

pp. 714-717 ◽

Cited By ~ 43

Author(s):

E Martin Caravati ◽

Carol J Adams ◽

Steven M Joyce ◽

Nathan C Schafer

Keyword(s):

Carbon Monoxide ◽

Carbon Monoxide Poisoning ◽

Fetal Toxicity

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Carboxyhemoglobin Concentration in Fetal Cord Blood and in Blood of Mothers Who Smoked During Labor

PEDIATRICS ◽

10.1542/peds.69.3.371 ◽

1982 ◽

Vol 69 (3) ◽

pp. 371-373

Author(s):

M. A. Bureau ◽

J. Monette ◽

D. Shapcott ◽

C. Paré ◽

J. -L. Mathieu ◽

...

Keyword(s):

Carbon Monoxide ◽

Maternal Smoking ◽

Animal Studies ◽

Carbon Monoxide Poisoning ◽

Fetal Brain ◽

Fetal Outcome ◽

Perinatal Complications ◽

Maternal Cigarette Smoking ◽

Fetal Toxicity ◽

Fetal Cord Blood

It has been established beyond doubt that maternal cigarette smoking is associated with increased perinatal morbidity (prematurity, failure to grow, vaginal bleeding of pregnancy) and perinatal mortality (abortion and fetal or neonatal death).1,2 Various mechanisms have been implicated to explain these adverse effects of maternal smoking on the fetal outcome and among these, chronic carbon monoxide intoxication of the fetus induced by maternal smoking is identified as a major cause of the fetal toxicity of smoking.3,4 In animal studies, chronic exposure to a low level of carbon monoxide produced perinatal complications similar to those reported in pregnant smokers,1,3,4 In humans, accidental carbon monoxide poisoning from sources other than smoking caused fetal death or fetal brain damage.5

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Embryotoxicity and fetal toxicity of nickel in rats

Toxicology and Applied Pharmacology ◽

10.1016/0041-008x(78)90017-0 ◽

1978 ◽

Vol 43 (2) ◽

pp. 381-390 ◽

Cited By ~ 77

Author(s):

F.William Sunderman ◽

Samuel K. Shen ◽

John M. Mitchell ◽

Patricia R. Allpass ◽

Ivan Damjanov

Keyword(s):

Fetal Toxicity

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