Relative parameter sensitivity in prenatal toxicity studies with substances classified as developmental toxicants

2012 ◽  
Vol 34 (2) ◽  
pp. 284-290 ◽  
Author(s):  
E. Rorije ◽  
F.J.W. van Hienen ◽  
Z.C. Dang ◽  
B.H. Hakkert ◽  
T. Vermeire ◽  
...  
2009 ◽  
Vol 28 (2) ◽  
pp. 196-202 ◽  
Author(s):  
Zhi-Chao Dang ◽  
Emiel Rorije ◽  
Thijs Hogen Esch ◽  
André Muller ◽  
Betty C. Hakkert ◽  
...  

2019 ◽  
Vol 301 ◽  
pp. 42-52 ◽  
Author(s):  
J. Keller ◽  
W. Mellert ◽  
S. Sperber ◽  
H. Kamp ◽  
X. Jiang ◽  
...  

1996 ◽  
Vol 10 (1) ◽  
pp. 43-49 ◽  
Author(s):  
James E. Ridings ◽  
Anthony K. Palmer ◽  
Elizabeth J. Davidson ◽  
John A. Baldwin

Author(s):  
Monique C. Braude ◽  
J. Michael Morrison
Keyword(s):  

2011 ◽  
Vol 49 (01) ◽  
Author(s):  
SA Hoffmann ◽  
M Lübberstedt ◽  
U Müller-Vieira ◽  
D Knobeloch ◽  
A Nüssler ◽  
...  

Author(s):  
Saravanakumar A ◽  
Gandhimathi R

Polygonum glabrum is being used in traditional and folklore medicine to treat pneumonia and jaundice. Plant roots are used in ayurvedic preparations to treat fever and colic. The leaves are used as diuretic agents and process vermifuge action. Plant decoction is also used in the treatment of Rheumatism. Besides having many uses and folklore claims, herbal medicines are to be thoroughly investigated for their toxicity also. Therefore this work is being carried out to examine the toxicity of the drug and established dose is safe to use in the clinical stage. The current research studied the acute and chronic toxicity of Polygonum glabrum root extract in rats. It is proved that there was no change in any parameter tested both in acute and chronic toxicity, which means the extract is safe and non-toxic at the dose of 2g/kg also.


2020 ◽  
Author(s):  
Zhaokai Dong ◽  
Daniel Bain ◽  
Murat Akcakaya ◽  
Carla Ng

A high-quality parameter set is essential for reliable stormwater models. Model performance can be improved by optimizing initial parameter estimates. Parameter sensitivity analysis is a robust way to distinguish the influence of parameters on model output and efficiently target the most important parameters to modify. This study evaluates efficient construction of a sewershed model using relatively low-resolution (e.g., 30 meter DEM) data and explores model sensitivity to parameters and regional characteristics using the EPA’s Storm Water Management Model (SWMM). A SWMM model was developed for a sewershed in the City of Pittsburgh, where stormwater management is a critical concern. We assumed uniform or log-normal distributions for parameters and used Monte Carlo simulations to explore and rank the influence of parameters on predicted surface runoff, peak flow, maximum pipe flow and model performance, as measured using the Nash–Sutcliffe efficiency metric. By using the Thiessen polygon approach for sub-catchment delineations, we substantially simplified the parameterization of the areas and hydraulic parameters. Despite this simplification, our approach provided good agreement with monitored pipe flow (Nash–Sutcliffe efficiency: 0.41 – 0.85). Total runoff and peak flow were very sensitive to the model discretization. The size of the polygons (modeled subcatchment areas) and imperviousness had the most influence on both outputs. The imperviousness, infiltration and Manning’s roughness (in the pervious area) contributed strongly to the Nash-Sutcliffe efficiency (70%), as did pipe geometric parameters (92%). Parameter rank sets were compared by using kappa statistics between any two model elements to identify generalities. Within our relatively large (9.7 km^2) sewershed, optimizing parameters for the highly impervious (>50%) areas and larger pipes lower in the network contributed most to improving Nash–Sutcliffe efficiency. The geometric parameters influence the water quantity distribution and flow conveyance, while imperviousness determines the subcatchment subdivision and influences surface water generation. Application of the Thiessen polygon approach can simplify the construction of large-scale urban storm water models, but the model is sensitive to the sewer network configuration and care must be taken in parameterizing areas (polygons) with heterogenous land uses.


2006 ◽  
Vol 11 (2) ◽  
pp. 115-119 ◽  
Author(s):  
Sung-Hee Lee ◽  
Kyeong-Nam Oh ◽  
Sook-Nyung Rho ◽  
Bok-Hee Lee ◽  
Hyun-Joo Lee

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