Periprosthetic osteolysis by microparticles mimicking a tumour process in the right hip in 18F-FDG PET/CT study

2021 ◽

Vol 52 (1) ◽

Author(s):

Almalki Yassir

Keyword(s):

Leydig Cell ◽

Fdg Pet ◽

Chronic Rejection ◽

Ct Imaging ◽

The Body ◽

Whole Body ◽

Pet Ct ◽

18F Fdg ◽

The Right ◽

Fdg Pet Ct

Abstract Background Leydig cell tumors (LCTs) represent the most common form of stromal tumors. We reported the 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) findings of a patient with testicular LCT. Case presentation A 50-year-old man with a history of end-stage renal disease and renal transplantation 19 years ago. One year earlier, he started to have a chronic rejection. During the investigation to determine the cause of chronic rejection, a suspicious lesion in the graft with a collection around it was seen on ultrasound (US) images, raising the possibility of post-transplant lymphoproliferative disorder (PTLD). The patient was referred for further evaluation by whole body 18F-FDG PET/CT imaging. The image finding revealed an incidental hypermetabolic focal lesion in the right testicle—no other specific findings in the remaining parts of the body nor definitive FDG avid lymphadenopathy to suggest PTLD. Testicular US was requested and showed a well-defined right-sided heterogeneous hypoechoic intratesticular focal mass at the upper pole of the right testis with significant internal vascularity on the color Doppler imaging. The patient underwent a right radical orchidectomy, and the tumor was pathologically confirmed as an LCT. Conclusion In our case, 18F-FDG-PET/CT has been helpful in incidentally detecting this rare testicular tumor in a patient with suspected PTLD.

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Abstract 35: DVT Inflammation Assessed by 18F-FDG-PET/CT Predicts Subsequent Vein Wall Scarring

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/atvb.36.suppl_1.35 ◽

2016 ◽

Vol 36 (suppl_1) ◽

Author(s):

Chase W Kessinger ◽

Ahmed Tawakol ◽

Gregory R Wojtkiewicz ◽

Peter K Henke ◽

Ralph Weissleder ◽

...

Keyword(s):

Fdg Pet ◽

Vena Cava ◽

Standard Uptake Value ◽

Vein Wall ◽

Positron Emission ◽

Pet Ct ◽

18F Fdg ◽

The Right ◽

Fdg Pet Ct

Objective: While venous thrombosis (VT)-induced inflammation facilitates thrombus resolution, inflammation causes vein wall scarring (VWS). Recently, statins have shown to improve VT resolution and reduce VT inflammatory components. In this study, we hypothesized that early VT inflammation detected by 18F-FDG positron emission tomography/computed tomography (PET/CT) could predict subsequent late stage VWS, and would be attenuated by statin therapy. Methods: Stasis VT was induced in 8-12 week old male C57BL/6 mice (n=31) in either the right jugular vein (n=13) or inferior vena cava (IVC,n=18). Animals in the IVC VT cohort were randomized to statin (n=8) or control (n=10) treatment. Statin, rosuvastatin (5mg/kg), was administered by oral gavage, daily starting 24 hours prior to VT induction; control mice received saline. All mice underwent survival FDG-PET/CT venography imaging on day 2. FDG inflammation signals (standard uptake value=SUV) were measured in the thrombosed vein and compared to the sham-operated venous segments or treatment control. On day 14, mice were sacrificed and VT tissue was resected. Picrosirius red staining allowed measurement of collagen and vein wall thickness in VT sections. Results: FDG-PET/CT at day 2 revealed increased inflammation signal activity in jugular VT (SUV 1.43 ± 0.3 VT vs. 0.81 ± 0.3 contralateral vein, p<0.0001). Statin-treated mice showed a trend of decreased inflammation signal at day 2 in the IVC VT models (SUV 1.02 ± 0.1 statin VT vs. 1.42 ± 0.2 control VT, p=0.07). Day 14 histological analysis revealed significantly reduced vein wall injury in statin-treated animals (thickness, 32±9.4 μm statin; vs. 56.2±14.7 μm control, p=0.02). Day 2 FDG-PET inflammation in VT correlated positively with the magnitude of day 14 VWS (jugular VT, Spearman r=0.62, p=0.02; IVC VT r=0.74, p<0.001, respectively). Conclusions: Quantitative FDG-PET/CT imaging demonstrates that early in vivo VT inflammation predicts subsequent VWS, a driver of post-thrombotic syndrome (PTS). The overall findings strengthen: (i) the link between inflammation and PTS; (ii) the translational potential of FDG-PET inflammation to predict VWS and PTS; and (iii) the concept that statins and other anti-inflammatory therapies could reduce VWS and PTS.

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Successful surgical management of hepatic alveolar echinococcosis by inductive therapy with albendazole – a case report

Zeitschrift für Gastroenterologie ◽

10.1055/a-1039-1755 ◽

2020 ◽

Vol 58 (01) ◽

pp. 63-67 ◽

Cited By ~ 1

Author(s):

Michael Bartels ◽

Thomas Schmidt ◽

Christoph Lübbert

Keyword(s):

Hepatic Vein ◽

Fdg Pet ◽

Alveolar Echinococcosis ◽

Postoperative Treatment ◽

Blood Levels ◽

Hepatic Alveolar Echinococcosis ◽

Pet Ct ◽

18F Fdg ◽

The Right ◽

Fdg Pet Ct

AbstractWe report the case of a 65-year-old female patient with hepatic alveolar echinococcosis (AE) caused by Echinococcus multilocularis. This infrequent zoonosis has a considerable morbidity and mortality. The malignant appearing hepatic mass was initially misdiagnosed as cholangiocarcinoma of the right hepatic lobe (segments VII, VIII, and IVa, sized 10.9 cm × 7.6 cm) involving the right and middle hepatic vein and extending close to the left hepatic vein. During exploratory laparotomy, the frozen-section biopsy was indicative of AE (World Health Organization [WHO] classification: stage P3N0M0). Due to the high operative risk, it was decided to pretreat the patient with albendazole as inductive therapy in order to remove the AE secondarily in accordance with the patient’s request. After year-long treatment with albendazole (under strict control of the maximum blood levels), a right hemihepatectomy was successfully performed. Postoperative treatment with albendazole had to be stopped prematurely after 11 months due to considerable subjective intolerance and a more-than-tenfold elevation of transaminases despite normal therapeutic albendazole blood levels. A 18F-FDG-PET/CT scan revealed no evidence of AE residues. Conducting follow-up examinations by 18F-FDG-PET/CT scans every 2 years is planned in order to recognize possible recurrence at an early stage.

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Changes in 18F-FDG PET-CT Appearances of Treated Malignant Melanoma Metastases within the Right Atrium

Molecular Imaging and Radionuclide Therapy ◽

10.4274/mirt.47955 ◽

2015 ◽

Vol 24 (suppl 1) ◽

pp. 25-27

Author(s):

Luke Ienari Sonoda ◽

Bal Sanghera ◽

Katharine Nowlan ◽

Emma Roantree ◽

Thomas Wagner ◽

...

Keyword(s):

Malignant Melanoma ◽

Right Atrium ◽

Fdg Pet ◽

Pet Ct ◽

Melanoma Metastases ◽

18F Fdg ◽

The Right ◽

Fdg Pet Ct

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Increased FDG uptake in AF individuals suggesting atrial inflammation visualized by FDG PET/CT with glucose uptake suppression protocols

European Heart Journal ◽

10.1093/eurheartj/ehab724.0324 ◽

2021 ◽

Vol 42 (Supplement_1) ◽

Author(s):

J Kupusovic ◽

M Weber ◽

L Kessler ◽

E Pesch ◽

L Riesinger ◽

...

Keyword(s):

Glucose Uptake ◽

Right Atrium ◽

Fdg Pet ◽

Left Atrial ◽

Right Atrial ◽

Fdg Uptake ◽

Pet Ct ◽

18F Fdg ◽

The Right ◽

Fdg Pet Ct

Abstract Background Pathophysiology of atrial fibrillation (AF) is multifactorial. Attention has been drawn towards atrial inflammation underlying arrhythmogenic remodeling. The aim of our study was to evaluate if a specific preparation protocol for positron emission tomography/computed tomography (PET/CT) with 18Fluor-labelled fluorodeoxyglucose (18F-FDG) was capable of detecting atrial hypermetabolism as surrogate for inflammation in AF, with the specific hypothesis that protocols specifically aiming to suppress physiologic glucose metabolism (fasting protocols: inflammation and malignancy preparation) were superior to non-fasting protocols. Methods We conducted a single-center study including n=75 patients with a history of AF and n=75 controls without AF (matched for age, sex and left ventricular systolic function) undergoing three different preparation protocols (each n=25 per group): i.) inflammation, ii.) malignancy and iii.) viability protocol before 18F-FDG-PET/CT. We performed visual analysis of local detectable atrial uptake (figure 1A) and assessed quantitative uptake in predetermined loci of the atria and endocrine adipose tissue (EAT), using maximum standardized uptake values (SUVmax) and target to background ratios (TBR). Results Our analysis of visual atrial 18F-FDG uptake revealed that atrial uptake was exclusively observed in AF patients using the malignancy (13/25 patients) and inflammation (10/25 patients) protocol, while the viability preparation revealed atrial uptake both in AF (n=6 patients) and non-AF patients (n=5 patients). With respect to quantitative measures between AF and non-AF individuals using the inflammation protocol, patients with AF showed significantly higher uptake values in the right atrium (SUVmax: 2.54±0.75 vs. 2.03±0.66, p=0.01); TBR 1.51±0.44 vs. 1.18±0.20, p<0.01), right atrial appendage (SUVmax: 2.44±0.71 vs. 2.02±0.64, p=0.03; TBR: 1.47±0.47 vs. 1.20±0.26, p=0.02) and also in EAT (SUVmax: 1.39±0.46 vs. 1.13±0.40, p=0.04), figure 1B. Despite a trend of higher tracer uptake related to the presence of AF in left atrial structures, no statistical significances could be observed between AF and non-AF individuals. Conclusion This retrospective study demonstrates that protocols specifically designed to suppress physiologic glucose uptake seem to be superior in detecting atrial FDG uptake, which could be indicative of atrial inflammation in AF patients. Based on our results the right atrium seems to be more affected from these changes. These results point towards a potential role of right atrial inflammatory processes in AF pathophysiology besides the established left atrial ectopic triggers. FUNDunding Acknowledgement Type of funding sources: None.

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Monostotic Fibrous Dysplasia Mimicking Metastasis in the Femoral Neck on Bone Scintigraphy and 18F-FDG PET/CT

Diagnostics ◽

10.3390/diagnostics10090682 ◽

2020 ◽

Vol 10 (9) ◽

pp. 682

Author(s):

Wei-Liang Hung ◽

Hung-Yen Chan ◽

Ni-Chun Kuo ◽

Hung-Pin Chan

Keyword(s):

Femoral Neck ◽

Fibrous Dysplasia ◽

Bone Scintigraphy ◽

Fdg Pet ◽

Treatment Plan ◽

Benign Lesion ◽

Pet Ct ◽

18F Fdg ◽

The Right ◽

Fdg Pet Ct

A 51-year-old woman who had lung adenocarcinoma was found to have a high uptake area over the right femoral neck by means of bone scintigraphy, suggesting a suspicious bony metastasis. 18F-FDG PET/CT was arranged, and showed an FDG-avid lesion in the same region. However, after augmented CT, a well-defined ground-glass lesion with circular calcification was found, which is the favored benign lesion of fibrous dysplasia. The following imaging of bone scintigraphy and 18F-FDG PET/CT presented no apparent change. This case demonstrates that the treatment scheme should not be solely guided by abnormalities in scintigraphy. Additional imaging is recommended for accurate staging or development of an appropriate treatment plan.

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False-Positive 18F-FDG PET/CT Uptake in Unilateral Lactation

Case Reports in Radiology ◽

10.1155/2020/8850052 ◽

2020 ◽

Vol 2020 ◽

pp. 1-4

Author(s):

Joshua Wei Liang Yip ◽

Han Loh ◽

Chuong Bui ◽

Veronica Chi Ken Wong ◽

Robert Mansberg

Keyword(s):

Soft Tissue ◽

Fdg Pet ◽

Bone Lesions ◽

Fdg Uptake ◽

Sclerotic Bone ◽

Pet Ct ◽

Sclerotic Bone Lesions ◽

18F Fdg ◽

The Right ◽

Fdg Pet Ct

A 31-year-old woman (7 months postpartum and lactating) with multiple sclerotic bone lesions was referred for an 18F-FDG PET/CT scan for characterization. The scan demonstrated unilateral diffuse intense FDG uptake corresponding to dense soft tissue in the right breast, likely related to secretory hyperplasia. On further questioning, it was made apparent that she had only been breastfeeding from the right breast. While the left breast also demonstrated dense soft tissue to a lesser degree, no significant FDG uptake was seen. The sclerotic bone lesions were not FDG avid, likely due to a separate non-FDG avid benign condition or bony metastases from a non-FDG avid primary malignancy. This was reinforced by the fact that subsequent investigations including serial bilateral breast ultrasound and percutaneous biopsy demonstrated no definite evidence of malignancy in the bilateral breasts. The histopathology findings of an open surgical biopsy of sclerotic lesions in the left posterior ilium were also nonspecific, favouring bone dysplasia with no evidence of malignancy.

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