Univariate versus multivariate spectrophotometric methods for the simultaneous determination of omarigliptin and two of its degradation products

2022 ◽  
pp. 120880
Author(s):  
Khadiga M. Kelani ◽  
Maha A. Hegazy ◽  
Amal M. Hassan ◽  
Mahmoud A. Tantawy
Keyword(s):  
Simultaneous Determination ◽  
Degradation Products ◽  
Spectrophotometric Methods

scholarly journals Multivariate Validated Models for Simultaneous Determination of Ibuprofen and Famotidine in the Presence of Related Substances

2018 ◽  
Vol 101 (4) ◽  
pp. 1001-1007
Author(s):  
Eman S Elzanfaly ◽  
Hala E Zaazaa ◽  
Aya T Soudi ◽  
Maissa Y Salem
Keyword(s):  
Simultaneous Determination ◽  
Multivariate Calibration ◽  
Degradation Products ◽  
Principal Component Regression ◽  
Principal Component ◽  
Standard Addition ◽  
Spectrophotometric Methods ◽  
Related Substances ◽  
Calibration Methods

Abstract Two multivariate validated spectrophotometric methods, namely partial least-squares (PLS) and principal component regression (PCR), were developed and validated for the determination of ibuprofen and famotidine in presence of famotidine degradation products and ibuprofen impurity (4-isobutylacetophenone). A calibration set was prepared in which the two drugs together with the degradation products and impurity were modeled using a multilevel multifactor design. This calibration set was used to build the PLS and PCR models. The proposed models successfully predicted the concentrations of both drugs in validation samples, with low root mean square error of cross validation (RMSECV) percentage. The method was validated by the estimate of the figures of merit depending on the net analyte signal. The results of the two models showed that the simultaneous determination of both drugs could be performed in the concentration ranges of 100–500 µg/mL for ibuprofen and 5–25 µg/mL for famotidine. The proposed multivariate calibration methods were applied for the determination of ibuprofen and famotidine in their pharmaceutical formulation, and the results were verified by the standard addition technique.

scholarly journals Three Different Spectrophotometric Methods for Simultaneous Determination of Pyriproxyfen and Chlorothalonil Residues in Cucumber and Cabbage Samples

2019 ◽  
Vol 2019 ◽  
pp. 1-11
Author(s):  
Shilan A. Omer ◽  
Nabil A. Fakhre
Keyword(s):  
Simultaneous Determination ◽  
Simultaneous Estimation ◽  
Zero Crossing ◽  
Spectrophotometric Methods ◽  
First Derivative ◽  
The Third ◽  
Mean Centering ◽  
Relative Standard ◽  
One Way Anova

In this study, three simple and accurate spectrophotometric methods for simultaneous determination of pyriproxyfen and chlorothalonil residues in cucumbers and cabbages grown in experimental greenhouse were studied. The first method was based on the zero-crossing technique measurement for first and second derivative spectrophotometry. The second method was based on the first derivative of the ratio spectra. However, the third method was based on mean centering of ratio spectra. These procedures lack any previous separation steps. The calibration curves for three spectrophotometric methods are linear in the concentration range of 1–30 μg·mL−1 and 0.5–7 μg·mL−1 for pyriproxyfen and chlorothalonil successively. The recoveries ranged from 82.12–97.40% for pyriproxyfen and 81.51–97.04% for chlorothalonil with relative standard deviations less than 4.95% and 5.45% in all instances for pyriproxyfen and chlorothalonil, respectively. The results obtained from the proposed methods were compared statistically by using one-way ANOVA, and the results revealed there were no significant differences between ratio spectra and mean centering methods with the zero-crossing technique. The proposed methods are successfully applied for the simultaneous estimation of the residue of both pesticides in cucumber and cabbage samples.

Simultaneous Determination of Diloxanide Furoate and Metronidazole in Presence of Diloxanide Furoate Degradation Products

2011 ◽  
Vol 94 (5) ◽  
pp. 1427-1439 ◽  
Author(s):  
Samah S. Abbas ◽  
Nour E. Wagieh ◽  
Mohamed Abdelkawy ◽  
Maha M. Abdelrahman
Keyword(s):  
Simultaneous Determination ◽  
Degradation Products

scholarly journals UV Spectrophotometric Simultaneous Determination of Paracetamol and Ibuprofen in Combined Tablets by Derivative and Wavelet Transforms

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Vu Dang Hoang ◽  
Dong Thi Ha Ly ◽  
Nguyen Huu Tho ◽  
Hue Minh Thi Nguyen
Keyword(s):  
Simultaneous Determination ◽  
Wavelet Transforms ◽  
Hybrid Approach ◽  
Uv Spectra ◽  
Order Derivative ◽  
First Order ◽  
Spectrophotometric Methods ◽  
Combined Use ◽  
Linear Concentration

The application of first-order derivative and wavelet transforms to UV spectra and ratio spectra was proposed for the simultaneous determination of ibuprofen and paracetamol in their combined tablets. A new hybrid approach on the combined use of first-order derivative and wavelet transforms to spectra was also discussed. In this application, DWT (sym6 and haar), CWT (mexh), and FWT were optimized to give the highest spectral recoveries. Calibration graphs in the linear concentration ranges of ibuprofen (12–32 mg/L) and paracetamol (20–40 mg/L) were obtained by measuring the amplitudes of the transformed signals. Our proposed spectrophotometric methods were statistically compared to HPLC in terms of precision and accuracy.

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