Interaction of Brain-Derived Neurotrophic Factor Val66Met genotype and history of stress in regulation of prepulse inhibition in mice

2018 ◽  
Vol 198 ◽  
pp. 60-67 ◽  
Author(s):  
Maarten van den Buuse ◽  
John Juan Wen Lee ◽  
Emily J. Jaehne
Keyword(s):  
Prepulse Inhibition ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
History Of

scholarly journals Circulating Levels of Brain-Derived Neurotrophic Factor and History of Suicide Attempts in Women

2017 ◽  
Vol 49 (1) ◽  
pp. 54-63 ◽  
Author(s):  
Anastacia Y. Kudinova ◽  
Terrence Deak ◽  
Molly M. Deak ◽  
Brandon E. Gibb
Keyword(s):  
Neurotrophic Factor ◽  
Suicide Attempts ◽  
Brain Derived Neurotrophic Factor ◽  
History Of ◽  
Circulating Levels

scholarly journals Recurrent Moderate Hypoglycemia Suppresses Brain-Derived Neurotrophic Factor Expression in the Prefrontal Cortex and Impairs Sensorimotor Gating in the Posthypoglycemic Period in Young Rats

2016 ◽  
Vol 38 (1) ◽  
pp. 74-82 ◽  
Author(s):  
Raghavendra Rao ◽  
Kathleen Ennis ◽  
Eugena P. Mitchell ◽  
Phu V. Tran ◽  
Jonathan C. Gewirtz
Keyword(s):  
Prefrontal Cortex ◽  
Prepulse Inhibition ◽  
Medial Prefrontal Cortex ◽  
Neurotrophic Factor ◽  
Sensorimotor Gating ◽  
Neuronal Injury ◽  
Brain Derived Neurotrophic Factor ◽  
Acoustic Startle Reflex ◽  
Fear Potentiated Startle ◽  
Recurrent Hypoglycemia

Recurrent hypoglycemia is common in infants and children. In developing rat models, recurrent moderate hypoglycemia leads to neuronal injury in the medial prefrontal cortex. To understand the effects beyond neuronal injury, 3-week-old male rats were subjected to 5 episodes of moderate hypoglycemia (blood glucose concentration, approx. 30 mg/dl for 90 min) once daily from postnatal day 24 to 28. Neuronal injury was determined using Fluoro-Jade B histochemistry on postnatal day 29. The effects on brain-derived neurotrophic factor (BDNF) and its cognate receptor, tyrosine kinase receptor B (TrkB) expression, which is critical for prefrontal cortex development, were determined on postnatal day 29 and at adulthood. The effects on prefrontal cortex-mediated function were determined by assessing the prepulse inhibition of the acoustic startle reflex on postnatal day 29 and 2 weeks later, and by testing for fear-potentiated startle at adulthood. Recurrent hypoglycemia led to neuronal injury confined primarily to the medial prefrontal cortex. BDNF/TrkB expression in the prefrontal cortex was suppressed on postnatal day 29 and was accompanied by lower prepulse inhibition, suggesting impaired sensorimotor gating. Following the cessation of recurrent hypoglycemia, the prepulse inhibition had recovered at 2 weeks. BDNF/TrkB expression in the prefrontal cortex had normalized and fear-potentiated startle was intact at adulthood. Recurrent moderate hypoglycemia during development has significant adverse effects on the prefrontal cortex in the posthypoglycemic period.

Repeated forced swimming impairs prepulse inhibition and alters brain-derived neurotrophic factor and astroglial parameters in rats

2015 ◽  
Vol 128 ◽  
pp. 50-61 ◽  
Author(s):  
Milene Borsoi ◽  
Camila Boque Antonio ◽  
Liz Girardi Müller ◽  
Alice Fialho Viana ◽  
Vivian Hertzfeldt ◽  
...  
Keyword(s):  
Prepulse Inhibition ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Forced Swimming

scholarly journals Targeted Genotyping Identifies Susceptibility Locus in Brain-derived Neurotrophic Factor Gene for Chronic Postsurgical Pain

2018 ◽  
Vol 128 (3) ◽  
pp. 587-597 ◽  
Author(s):  
Yuanyuan Tian ◽  
Xiaodong Liu ◽  
Mingzhong Jia ◽  
Hui Yu ◽  
Peter Lichtner ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Population Attributable Risk ◽  
Pain Syndrome ◽  
Brain Derived Neurotrophic Factor ◽  
Prior History ◽  
Nucleotide Polymorphisms ◽  
Postsurgical Pain ◽  
Increased Risk ◽  
Chronic Postsurgical Pain ◽  
History Of

Abstract Background The purpose of this study was to evaluate the association between single-nucleotide polymorphisms and chronic postsurgical pain. Methods Using GoldenGate genotyping assays, we genotyped 638 polymorphisms within 54 pain-related genes in 1,152 surgical patients who were enrolled in our Persistent Pain after Surgery Study. Patients were contacted by phone to determine whether they had chronic postsurgical pain at 12 months. Polymorphisms identified were validated in a matched cohort of 103 patients with chronic postsurgical pain and 103 patients who were pain free. The functions of targeted polymorphisms were tested in an experimental plantar incisional nociception model using knock-in mice. Results At 12 months after surgery, 246 (21.4%) patients reported chronic postsurgical pain. Forty-two polymorphisms were found to be associated with chronic postsurgical pain, 19 decreased the risk of pain, and 23 increased the risk of pain. Patients carrying allele A of rs6265 polymorphism in brain-derived neurotrophic factor (BDNF) had a lower risk of chronic postsurgical pain in the discovery and validation cohorts, with an adjusted odds ratio (95% CI) of 0.62 (0.43 to 0.90) and 0.57 (0.39 to 0.85), respectively. Age less than 65 yr, male sex, and prior history of pain syndrome were associated with an increased risk of pain. Genetic polymorphisms had higher population attributable risk (7.36 to 11.7%) compared with clinical risk factors (2.90 to 5.93%). Importantly, rs6265 is a substitution of valine by methionine at amino acid residue 66 (Val66Met) and was associated with less mechanical allodynia in BDNFMet/Met mice compared with BDNFVal/Val group after plantar incision. Conclusions This study demonstrated that genetic variant of BDNF rs6265G>A is associated with decreased risk of chronic postsurgical pain.

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