Ten-year trajectory and outcomes of negative symptoms of patients with first-episode schizophrenia spectrum disorders

Abstract Background In this study, we explored the relationship between hippocampal subfield volumes and change in body mass over 12 months of treatment in 90 first-episode schizophrenia spectrum disorder patients (66 males, 24 females; mean age= 24.7±6.8 years). Methods Body mass index was assessed in patients at baseline, and at months 3, 6, 9 and 12. Hippocampal subfields of interest were assessed using a segmentation algorithm included in the FreeSurfer 6.0 software program. Results Linear regression analysis showed a significant interactive effect between sex and anterior hippocampus size as a predictor of change in body mass over 12 months, adjusting for age, substance use, treatment duration, and posterior hippocampal volumes. In an exploratory sub-analysis, partial correlations revealed a significant association between weight gain and smaller CA1, CA3 and subiculum volumes in females, but not males, adjusting for age and substance use, with similar trends evident for the CA4 and presubiculum subfields. Discussion In conclusion, our findings suggest that smaller anterior hippocampal subfields are associated with the development of weight gain over the course of treatment in first-episode schizophrenia spectrum disorders in a sex-specific fashion, and may partly explain the more severe and ongoing increase in body mass evident for female patients.

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SA33. In-Between Cognitive Domains Correlations in First-Episode Schizophrenia Spectrum Disorders

Schizophrenia Bulletin ◽

10.1093/schbul/sbx023.032 ◽

2017 ◽

Vol 43 (suppl_1) ◽

pp. S125-S125

Author(s):

Mabel Virginia Rodriguez Manchola ◽

Zuzana Kratochvilova

Keyword(s):

First Episode ◽

Schizophrenia Spectrum Disorders ◽

Cognitive Domains ◽

Schizophrenia Spectrum ◽

Spectrum Disorders ◽

First Episode Schizophrenia

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Depressive psychopathology in first-episode schizophrenia spectrum disorders: a systematic review, meta-analysis and meta-regression

Psychological Medicine ◽

10.1017/s0033291719002344 ◽

2019 ◽

Vol 49 (15) ◽

pp. 2463-2474 ◽

Cited By ~ 5

Author(s):

Sarah E. Herniman ◽

Kelly Allott ◽

Lisa J. Phillips ◽

Stephen J. Wood ◽

Jacqueline Uren ◽

...

Keyword(s):

Systematic Review ◽

Depressive Disorder ◽

Meta Analysis ◽

First Episode ◽

Schizophrenia Spectrum Disorders ◽

Schizophrenia Spectrum ◽

Pooled Prevalence ◽

Meta Regression ◽

Spectrum Disorders ◽

First Episode Schizophrenia

AbstractBackgroundDespite knowing for many decades that depressive psychopathology is common in first-episode schizophrenia spectrum disorders (FES), there is limited knowledge regarding the extent and nature of such psychopathology (degree of comorbidity, caseness, severity) and its demographic, clinical, functional and treatment correlates. This study aimed to determine the pooled prevalence of depressive disorder and caseness, and the pooled mean severity of depressive symptoms, as well as the demographic, illness, functional and treatment correlates of depressive psychopathology in FES.MethodsThis systematic review, meta-analysis and meta-regression was prospectively registered (CRD42018084856) and conducted in accordance with PRISMA and MOOSE guidelines.ResultsForty studies comprising 4041 participants were included. The pooled prevalence of depressive disorder and caseness was 26.0% (seven samples, N = 855, 95% CI 22.1–30.3) and 43.9% (11 samples, N = 1312, 95% CI 30.3–58.4), respectively. The pooled mean percentage of maximum depressive symptom severity was 25.1 (38 samples, N = 3180, 95% CI 21.49–28.68). Correlates of depressive psychopathology were also found.ConclusionsAt least one-quarter of individuals with FES will experience, and therefore require treatment for, a full-threshold depressive disorder. Nearly half will experience levels of depressive symptoms that are severe enough to warrant diagnostic investigation and therefore clinical intervention – regardless of whether they actually fulfil diagnostic criteria for a depressive disorder. Depressive psychopathology is prominent in FES, manifesting not only as superimposed comorbidity, but also as an inextricable symptom domain.

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Substance abuse and first-episode schizophrenia-spectrum disorders. The Danish OPUS trial

Early Intervention in Psychiatry ◽

10.1111/j.1751-7893.2007.00015.x ◽

2007 ◽

Vol 1 (1) ◽

pp. 88-96 ◽

Cited By ~ 26

Author(s):

Lone Petersen ◽

Pia Jeppesen ◽

Anne Thorup ◽

Johan Øhlenschlæger ◽

Gertrud Krarup ◽

...

Keyword(s):

Substance Abuse ◽

First Episode ◽

Schizophrenia Spectrum Disorders ◽

Schizophrenia Spectrum ◽

Spectrum Disorders ◽

First Episode Schizophrenia

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Hallucinations without delusions in patients with first-episode psychosis: Clinical correlates and implications for pathophysiological models

European Psychiatry ◽

10.1016/j.eurpsy.2016.01.859 ◽

2016 ◽

Vol 33 (S1) ◽

pp. S32-S32

Author(s):

I. Melle

Keyword(s):

Negative Symptoms ◽

Clinical Symptoms ◽

Age At Onset ◽

Diagnostic Interview ◽

Clinical Profile ◽

First Episode ◽

Schizophrenia Spectrum Disorders ◽

Schizophrenia Spectrum ◽

Spectrum Disorders ◽

Competing Interest

IntroductionThe symptomatic distribution in schizophrenia spectrum disorder is heterogeneous. Patients may experience hallucinations, delusions and combinations thereof, in addition to disorganized and negative symptoms. We have previously found that patients with monosymptomatic hallucinations exhibited a different clinical profile than patients with monosymptomatic delusions or combinations of the two; with an earlier age at onset and more suicidal symptoms.AimsTo replicate findings in a new group of patients with schizophrenia spectrum disorders.MethodsA total of 421 consecutive patients with schizophrenia spectrum disorders were included into the study. They were comprehensively assessed by specifically trained psychiatrists or clinical psychologists; using the SCID for DSM-IV for diagnostic purposes, the PANSS to assess current clinical symptoms and CDSS to assess current depression. Lifetime presence of different symptom types was ascertained during the diagnostic interview.ResultsA total of 346 (82%) had experienced both hallucinations and delusion, 63 (15%) had experienced delusions without hallucinations, 10 (2.5%) had experienced hallucinations without delusions and 2 patients (0.5%) had neither but experienced negative and severely disorganized symptoms. Contrary to hypothesis, we did not find any statistically significant differences in age at onset and in clinical symptoms (including suicidality) between these groups. We also did not find any differences in the type of hallucinatory experiences between hallucinating groups.ConclusionsIn a new sample of patients, we did not replicate previous findings of a different clinical profile in patients with monosymptomatic hallucinations. This type of psychotic disorder is relatively rare, which might pose a problem concerning statistical strength.Disclosure of interestThe author has not supplied his declaration of competing interest.

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