Gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice: Neurobehavioral effects on female offspring

2021 ◽  
Vol 752 ◽  
pp. 141784
Author(s):  
Rui Sha ◽  
Yangsheng Chen ◽  
Yijing Wang ◽  
Yali Luo ◽  
Yiyun Liu ◽  
...  
Keyword(s):  
Female Offspring ◽  
Lactational Exposure ◽  
Tetrachlorodibenzo P Dioxin ◽  
Neurobehavioral Effects

In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) affects bone tissue in rhesus monkeys

Toxicology ◽  
2008 ◽  
Vol 253 (1-3) ◽  
pp. 147-152 ◽  
Author(s):  
Sanne A.B. Hermsen ◽  
Sune Larsson ◽  
Akihiro Arima ◽  
Atsunobu Muneoka ◽  
Toshio Ihara ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Rhesus Monkeys ◽  
In Utero ◽  
Lactational Exposure ◽  
Tetrachlorodibenzo P Dioxin

In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin

1992 ◽  
Vol 114 (1) ◽  
pp. 118-126 ◽  
Author(s):  
Thomas A. Mably ◽  
Donald L. Bjerke ◽  
Robert W. Moore ◽  
Annette Gendron-Fitzpatrick ◽  
Richard E. Peterson
Keyword(s):  
In Utero ◽  
Male Rats ◽  
Lactational Exposure ◽  
Tetrachlorodibenzo P Dioxin

Lactational Exposure of Han/Wistar Rats to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Interferes with Enamel Maturation and Retards Dentin Mineralization

2004 ◽  
Vol 83 (2) ◽  
pp. 139-144 ◽  
Author(s):  
Y. Gao ◽  
C. Sahlberg ◽  
A. Kiukkonen ◽  
S. Alaluusua ◽  
R. Pohjanvirta ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Cell Function ◽  
Causative Factor ◽  
Enamel Matrix ◽  
Lactational Exposure ◽  
Aryl Hydrocarbon ◽  
Tooth Mineralization ◽  
Cyp1a1 Expression ◽  
Enamel Mineralization ◽  
Tetrachlorodibenzo P Dioxin

Exposure to environmental dioxins via mother’s milk may be one causative factor of mineralization defects in children’s teeth. A prerequisite for the completion of enamel mineralization is the removal of enamel matrix. To test the hypothesis that dioxins interfere with enamel maturation, we administered lactating Han/Wistar rats a single dose of 2,3,7,8-tetrachlorodibenzo -p-dioxin (TCDD; 50 or 1000 μg/kg) on the day after delivery and analyzed tissue sections of the pup heads at post-natal days (Pn) 9 and 22. By Pn22, the first and second molars of the exposed pups, but not controls, showed retention of enamel matrix. Predentin was thicker than normal. Immunostaining for the aryl hydrocarbon/dioxin receptor (AhR) and cytochrome P4501A1 (CYP1A1) in ameloblasts and odontoblasts was reduced, suggesting that TCDD interferes with tooth mineralization via AhR. Extinction of AhR may lead to abolition of CYP1A1 expression as a sign of impaired dental cell function.

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