Effects of Gundelia tournefortii L. on biochemical parameters, antioxidant activities and DNA damage in a rat model of experimental obesity

The present study was designed to investigate the effects of Gundelia tournefortii L. plant extract on different tissues in terms of DNA damage, biochemical and antioxidant parameter values in rats with high-calorie diets. With this aim, Wistar albino male rats were divided into 4 groups containing 6 rats each and the study was completed over 12 weeks duration. At the end of the implementation process over the 12 weeks, rats were sacrificed and blood and tissue samples were obtained. Analyses were performed on blood and tissue samples. According to results for DNA damage (8-OHdG), in brain tissue the OG2 group was significantly reduced compared to the NC group. For MDA results in liver tissue, OG1 and OG2 groups were determined to increase by a significant degree compared to the control group, while the OG2 group was also increased significantly compared to the obese group. In terms of the other parameters, comparison between the groups linked to consumption of a high calorie diet (HCD) and administration of Gundelia tournefortii L. in terms of antioxidant activities and serum samples obtained statistically significant results. Gundelia tournefortii L. plant extracts had effects that may be counted as positive on antioxidant parameter activity and were especially identified to improve DNA damage and MDA levels in brain tissues. Additionally, consumption of Gundelia tournefortii L. plant extract in the diet may have antiobesity effects; thus, it should be evaluated for use as an effective weight-loss method and as a new therapeutic agent targeting obesity.

Levels of dopamine, 5-hydroxytryptamine and their metabolites in the striatum of rats of various strains receiving a high-calorie diet

The aim of this work was to study the effect of a high fat and carbohydrate diet (HFCD) and quercetin supplementation on the levels of dopamine (DA), serotonin (5-HT) and their metabolites in Wistar, DA transporter knockout (DAT-KO) and obese Zucker fa/fa rats. Animals received a control diet or HFCD for 62 days. Wistar and Zucker fa/fa rats received quercetin. The contents of DA, 5-HT, norepinephrine (NE), dioxyphenyl acetate (DOPAC), homovanillic acid (HVA) and 5-hydroxyindolyl acetate (5-HIIA) in the striatum were determined by high-performance liquid chromatography (HPLC). DAT-KO homozygotes had lowered DA and increased HVA and DOPAC compared to Wistar rats. HFCD did not affect the content of NE and 5-HT. 5-HT was increased in DAT-KO homozygotes compared with Wistar receiving a control diet. 5-HIIA accumulated in larger amounts in DAT-KO compared to Wistar with the exception of those receiving quercetin with a control diet. Quercetin did not affect the levels of DA, 5-HT and their metabolites.

Efficacy and Mechanism of Action of Aloe Vera, Cinnamomum Zeylanicum, Curcuma Longa, Garcinia Cambogia, and Garcinia Mangostana Extracts in Lowering Body Weight in Obesity: A Literature Review

The habits of today's society, which are influenced by economic growth and globalization have brought new lifestyles, especially those related to diet, resulting in minimal physical activity accompanied by a high calorie intake. This energy imbalance can lead to the metabolic syndrome, including obesity, which is still a burden on the world today. Some plants in Indonesia are believed to help lose weight, such as Aloe vera, Cinnamomum zeylanicum, Curcuma longa, Garcinia cambogia, and Garcinia mangostana. This literature review was conducted to determine the effects of Aloe vera, Cinnamomum zeylanicum, Curcuma longa, Garcinia cambogia, and Garcinia mangostana on weight loss and preventing obesity. The review of twelve relevant articles concluded that Aloe vera, Cinnamomum zeylanicum, Curcuma longa, Garcinia cambogia, and Garcinia mangostana have the potential to prevent and treat obesity but further research is required.

Patient, carer and healthcare professional perspectives on increasing calorie intake in Amyotrophic Lateral Sclerosis

Objectives Research suggests that higher Body Mass Index is associated with improved survival in people with Amyotrophic Lateral Sclerosis (pwALS). Yet, understanding of the barriers and enablers to increasing calorie intake is limited. This study sought to explore these issues from the perspective of pwALS, informal carers, and healthcare professionals. Methods Interviews with 18 pwALS and 16 informal carers, and focus groups with 51 healthcare professionals. Data were analysed using template analysis and mapped to the COM-B model and Theoretical Domains Framework (TDF). Results All three COM-B components (Capability, Opportunity and Motivation) are important to achieving high calorie diets in pwALS. Eleven TDF domains were identified: Physical skills (ALS symptoms); Knowledge (about high calorie diets and healthy eating); Memory, attention, and decision processes (reflecting cognitive difficulties); Environmental context/resources (availability of informal and formal carers); Social influences (social aspects of eating); Beliefs about consequences (healthy eating vs. high calorie diets); Identity (interest in health lifestyles); Goals (sense of control); Reinforcement (eating habits); and Optimism and Emotion (low mood, poor appetite). Discussion To promote high calorie diets for pwALS, greater clarity around the rationale and content of recommended diets is needed. Interventions should be tailored to patient symptoms, preferences, motivations, and opportunities.

BIOELEMENTS: ROLE IN THE DEVELOPMENT OF DISEASES OF CIVILIZATION

The modern diseases of civilization include obesity, diabetes mellitus or insulin resistance, atherosclerosis, neurodegenerative and oncological diseases. Much more often, a modern person makes a choice in favor of tasty and high-calorie food, which is not standard in terms of the content of vitamins, amino acids, fatty acids and minerals. It is difficult to imagine that such a chronic deficiency of essential molecules could be beneficial for the evolution of humanity. Rather, on the contrary, we observe a number of metabolic changes, including those due to dysmicroelementosis, which undoubtedly lead to the development of various diseases of civilization. In this review, we presented the key functions of micronutrients and pathological conditions associated with their deficiency.

Food-drug interaction as a risk factor of drug-induced diseases: epidemiology, risk factors, potential mechanisms of interaction

Any drug is potentially associated with the risk of adverse drug reactions (ADRs), the incidence of which in developed and developing countries is estimated at 6.3 (3.3—11.0) and 5.5 % (1.1—16.9), respectively. Many ADRs increase mortality and / or morbidity and / or cause clinical manifestations that require a patient to seek medical help or hospitalization; a special term has been introduced — drug-induced diseases. Food can interact with drugs and increase the risk of ADRs, including serious ones. The simultaneous intake of food and drugs can affect the bioavailability, pharmacokinetics, pharmacodynamics and therapeutic efficacy of drugs due to changes in drug absorption and metabolism. A striking example of the effect of food on the pharmacokinetic profile of drugs is the change in the bioavailability of the tyrosine kinase inhibitor lapatinib: compared with taking on an empty stomach, the bioavailability of lapatinib in a single dose of 1 500 mg after taking it together with high-calorie standard food increases by an average of 325 % — 4.25 times. In other words, the concentration of the drug in the blood serum after taking one tablet at the same time with food is comparable to taking 4 tablets on an empty stomach. Currently, there are no recommendations for choosing a dosage regimen for drugs depending on the qualitative and quantitative composition of food, as well as taking into account potential interactions with food components, although these recommendations are extremely necessary for patients and healthcare professionals. In this regard, this article summarizes the data available at the time of writing in open sources concerning the effect of food on the absorption and metabolism of drugs, and also describes the possible mechanisms of interaction.

The Role of Attentional Bias in Excessive Food Consumption

<p>New Zealand obesity rates have reached epidemic proportions. Excessive eating not only harms individual health, but also the NZ economy; health-related costs soar with rising obesity rates. The need to understand possible mechanisms driving excessive eating behaviour is now crucial. One cognitive mechanism thought to contribute to excessive eating is an attentional bias towards food stimuli. We propose this bias would be similar to the attentional bias that is consistently shown with emotional stimuli (e.g. erotic and mutilation images). In this thesis I examined attentional biases towards food stimuli and how they relate to both state (hunger) and trait (waist circumference) factors. In Experiment 1, I investigated the existence of a food-related attentional bias and whether this bias is stronger towards high calorie food images, compared to low-calorie and non-food images (household objects). Participants were asked to fast for 2 hours (to promote self-reported hunger) before completing a distraction task. This task has repeatedly shown an attentional bias to high arousal emotional images (erotic and mutilation scenes). On each trial, participants had to determine whether a target letter was a ‘K’ or an ‘N’, while ignoring centrally-presented distractors (high calorie, low calorie and household object images). Compared to scrambled images, all image types were similarly distracting. We found no support for the existence of an attentional bias towards food stimuli; nor did we find a significant association between the bias and either state or trait factors. Experiment 2 sought to conceptually replicate Cunningham & Egeth (2018) who found significant support for the existence of a food-related attentional bias. Participants completed a similar task. However, distractor relevance was manipulated by incorporating both central and peripheral distractors, to increase ecological validity. Additionally, participants were asked to fast for longer (4 hours) to increase self-reported hunger. Despite a significant distraction effect (participants were more distracted on distractor present vs. distractor absent trials) and distractor-location effect (participants were more distracted by central vs. peripheral distractors), participants did not exhibit an attentional bias towards food stimuli. Furthermore, no significant associations between the bias and either state or trait factors were found. Thus, food stimuli do not appear to rapidly capture attention the way that emotional stimuli do, at least not in this task. Future research is needed to clarify the role of cognitive mechanisms in excessive eating behaviour.</p>

The Role of Attentional Bias in Excessive Food Consumption

<p>New Zealand obesity rates have reached epidemic proportions. Excessive eating not only harms individual health, but also the NZ economy; health-related costs soar with rising obesity rates. The need to understand possible mechanisms driving excessive eating behaviour is now crucial. One cognitive mechanism thought to contribute to excessive eating is an attentional bias towards food stimuli. We propose this bias would be similar to the attentional bias that is consistently shown with emotional stimuli (e.g. erotic and mutilation images). In this thesis I examined attentional biases towards food stimuli and how they relate to both state (hunger) and trait (waist circumference) factors. In Experiment 1, I investigated the existence of a food-related attentional bias and whether this bias is stronger towards high calorie food images, compared to low-calorie and non-food images (household objects). Participants were asked to fast for 2 hours (to promote self-reported hunger) before completing a distraction task. This task has repeatedly shown an attentional bias to high arousal emotional images (erotic and mutilation scenes). On each trial, participants had to determine whether a target letter was a ‘K’ or an ‘N’, while ignoring centrally-presented distractors (high calorie, low calorie and household object images). Compared to scrambled images, all image types were similarly distracting. We found no support for the existence of an attentional bias towards food stimuli; nor did we find a significant association between the bias and either state or trait factors. Experiment 2 sought to conceptually replicate Cunningham & Egeth (2018) who found significant support for the existence of a food-related attentional bias. Participants completed a similar task. However, distractor relevance was manipulated by incorporating both central and peripheral distractors, to increase ecological validity. Additionally, participants were asked to fast for longer (4 hours) to increase self-reported hunger. Despite a significant distraction effect (participants were more distracted on distractor present vs. distractor absent trials) and distractor-location effect (participants were more distracted by central vs. peripheral distractors), participants did not exhibit an attentional bias towards food stimuli. Furthermore, no significant associations between the bias and either state or trait factors were found. Thus, food stimuli do not appear to rapidly capture attention the way that emotional stimuli do, at least not in this task. Future research is needed to clarify the role of cognitive mechanisms in excessive eating behaviour.</p>