Rational design of microporous biochar based on ion exchange using carboxyl as an anchor for high-efficiency capture of gaseous p-xylene

Abstract The gestational trophoblastic tumor seriously endangers child productive needs and the health of women in childbearing age. Nanodrug-based therapy mediated by transporters provides novel strategy for the treatment of trophoblastic tumors. Focus on the overexpressed human equilibrative nucleoside transporter 1 (ENT1) on the membrane of choriocarcinoma cells (JEG-3), the cytarabine (Cy, a substrate of ENT1) grafted liposome (Cy-Lipo) was introduced for targeted delivery of methotrexate (Cy-Lipo@MTX) for choriocarcinoma therapy in this study. The ENT1 has high affinity for Cy-Lipo and can mediate the endocytosis of the designed nanovehicles into JEG-3 cells. The ENT1 protein maintains its transporting function through circulation and regeneration during endocytosis. Therefore, Cy-Lipo-based formulations achieved high tumor accumulation and retention in pharmacokinetic and distribution studies. More importantly, the designed Cy-lipid conjugation exhibited a synergistic therapeutic effect on choriocarcinoma. Finally, Cy-Lipo@MTX exerts an extremely powerful anti-choriocarcinoma effect with fewer side effects. This study suggests that the overexpressed ENT1 on choriocarcinoma cells holds a great potential to be a high-efficiency target for the rational design of active targeting nanotherapeutics.

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Preparation and characterization of high efficiency ion-exchange crosslinked acrylic fibers

Journal of Applied Polymer Science ◽

10.1002/app.23465 ◽

2006 ◽

Vol 101 (4) ◽

pp. 2202-2209 ◽

Cited By ~ 54

Author(s):

Ahmad M. Shoushtari ◽

Mojdeh Zargaran ◽

Majid Abdouss

Keyword(s):

Ion Exchange ◽

High Efficiency ◽

Acrylic Fibers

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Comprehensive Evaluation of Transition Metal Doped Ni3N to Construct High-Efficiency Hydrogen Evolution Catalyst

10.21203/rs.3.rs-819563/v1 ◽

2021 ◽

Author(s):

Meng Wang ◽

Zepeng Lv ◽

Xuewei Lv ◽

Qian Li ◽

Jie Dang

Keyword(s):

Transition Metal ◽

Hydrogen Evolution ◽

Density Functional ◽

Rational Design ◽

Dft Calculation ◽

High Efficiency ◽

Comprehensive Evaluation ◽

Low Cost ◽

Alkaline Electrolyte ◽

Metal Doped

Abstract Density functional theory (DFT) calculation indicators (ΔG, densities of state, D-band and bader charge) are commonly used to predict and analyze the hydrogen evolution reaction (HER) activity of catalysts, and most studies discuss only one or few of these indicators’ impact on catalysis, but still no report has comprehensively evaluated the influence of all these indicators on catalytic performance. Herein, foreseen by comprehensive consideration first, we report transition metal doped Ni3N nanosheets combined on Ni foam for utra-efficient alkaline hydrogen evolution. For dual transition metals doped Ni3N, Co,V-Ni3N exhibits remarkable HER performance with a significantly low overpotential of only 10 mV in alkaline electrolyte and 41 mV in alkaline seawater electrolyte at 10 mA cm− 2; while for single transition metal doped Ni3N, V-Ni3N exhibits the best performance with an overpotential of 15 mV and a Tafel slope of 37 mV dec− 1. Our work highlights the importance of comprehensive evaluation of DFT calculation indexes, and opens up a new method for the rational design of efficient and low-cost catalysts.

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Fe-Co-P multi-heterostructure arrays for efficient electrocatalytic water splitting

Journal of Materials Chemistry A ◽

10.1039/d1ta06603j ◽

2021 ◽

Author(s):

Hanwen Xu ◽

Jiawei Zhu ◽

Pengyan Wang ◽

Ding Chen ◽

Chengtian Zhang ◽

...

Keyword(s):

Hydrogen Production ◽

Hydrogen Evolution ◽

Water Splitting ◽

Oxygen Evolution ◽

Hydrogen Evolution Reaction ◽

Oxygen Evolution Reaction ◽

Rational Design ◽

Large Scale ◽

High Efficiency ◽

Bifunctional Catalysts

Rational design and construction of high-efficiency bifunctional catalysts for hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) is crucial for large-scale hydrogen production by water splitting. Herein, by a...

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