Tissue residue levels of florfenicol, ceftiofur, tulathromycin, oxytetracycline, cydectin in white-tailed deer (Odocoileus virginanus) at 11, 21, and 31 days post intramuscular injection

A newly formulated colistin sulphate solution was prepared in a previous study as a potential agent for intramuscular injection and its effectiveness, toxicity and pharmacokinetics were investigated. In order to provide more information to establish scientific guidance for safe use of this preparation, its residue depletion in swine tissues following intramuscular administration was investigated in this experiment. Fifty healthy cross-bred piglets (13.3 ± 0.9 kg) were used in this study. Five animals were kept as untreated controls and the other 45 animals were intramuscularly injected with the colistin preparation at a dose of 2.5 mg / kg of body weight. From the treated piglets, 5 animals were randomly selected and sacrificed at different withdrawal times. Liver, kidney and muscle tissues were sampled to examine the colistin residue levels by microbiological assay. The results showed that the colistin residue in liver and muscle decreased quickly and could not be detected at 1 day after the final dosing. However, the residue depletion in the kidneys was much slower than that in other tissues and even a small quantity of drug could be detected at 14 days after withdrawal. Using the method recommended by the Committee for Veterinary Medical Products (CVMP), a withdrawal time of 10 days was established for the safe use of the newly formulated colistin sulphate solution.

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Effects of brodifacoum and diphacinone exposure on four species of reptiles: tissue residue levels and survivorship

Pest Management Science ◽

10.1002/ps.5730 ◽

2020 ◽

Vol 76 (5) ◽

pp. 1958-1966

Author(s):

Richard E Mauldin ◽

Gary W Witmer ◽

Susan A Shriner ◽

Rachael S Moulton ◽

Katherine E Horak

Keyword(s):

Tissue Residue ◽

Residue Levels

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Tissue Residue Levels after Immobilization of Rocky Mountain Elk (Cervus elaphus nelsoni) using a Combination of Nalbuphine, Medetomidine, and Azaperone Antagonized with Naltrexone, Atipamezole, and Tolazoline

Journal of Wildlife Diseases ◽

10.7589/2017-06-132 ◽

2018 ◽

Vol 54 (2) ◽

pp. 362-365 ◽

Cited By ~ 2

Author(s):

Lisa L. Wolfe ◽

Pauline Nol ◽

Matthew P. McCollum ◽

Travis Mays ◽

Morgan E. Wehtje ◽

...

Keyword(s):

Cervus Elaphus ◽

Rocky Mountain ◽

Tissue Residue ◽

Cervus Elaphus Nelsoni ◽

Residue Levels ◽

Rocky Mountain Elk

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Tissue residue levels in rabbits and rats poisoned with 1080 One-shot bait and the location of poisoned rabbit carcasses

Wildlife Research ◽

10.1071/wr02098 ◽

2003 ◽

Vol 30 (6) ◽

pp. 621 ◽

Cited By ~ 3

Author(s):

Laurie E. Twigg ◽

Tim J. Lowe ◽

Winifred E. Kirkpatrick ◽

Gary R. Martin

Keyword(s):

Pest Control ◽

Potential Risk ◽

Secondary Poisoning ◽

Tissue Residue ◽

Control Programs ◽

Highly Sensitive ◽

Residue Levels

The level of fluoroacetate (1080) found in the carcasses of rats and rabbits poisoned with 1080 ranged from 1.9 to 14.4 μg g–1 (mean 5.3 μg g–1, n = 11) in rats and <0.02 to 0.78 μg g–1 (mean 0.353 μg g–1, n = 10) in rabbits. The concentration of fluoroacetate in the blood and liver of both species was generally higher than in the carcasses, and ranged from <0.02 to 33.6 μg g–1. Fifteen of 22 collared rabbits, and 3 freshly killed, uncollared rabbits were recovered during a routine baiting exercise with 1080 One-shot oats. Excluding the 4 collared rabbits taken by predators, only 14% of all carcasses (n = 14) were found in the open, with the remaining 86% of carcasses being well concealed in warrens or under thick scrub. The carcasses of both rabbits and rats showed considerable decay within 6 days of poisoning. Except for eutherian carnivores, which are highly sensitive to 1080, there is little potential risk of secondary poisoning of native wildlife as a result of the correct use of 1080 baits in pest-control programs.

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Depletion of Penicillin G Residues in Heavy Sows after Intramuscular Injection. Part I: Tissue Residue Depletion

Journal of Agricultural and Food Chemistry ◽

10.1021/jf501492v ◽

2014 ◽

Vol 62 (30) ◽

pp. 7577-7585 ◽

Cited By ~ 6

Author(s):

S. J. Lupton ◽

W. L. Shelver ◽

D. J. Newman ◽

S. Larsen ◽

D. J. Smith

Keyword(s):

Intramuscular Injection ◽

Penicillin G ◽

Tissue Residue ◽

Residue Depletion

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Correlation between Cadmium Concentration in the Water and Tissue Residue Levels in Dab, Limanda Limanda L., and Plaice, Pleuronectes Platessa L.

Journal of the Marine Biological Association of the United Kingdom ◽

10.1017/s0025315400024103 ◽

1980 ◽

Vol 60 (1) ◽

pp. 45-58 ◽

Cited By ~ 15

Author(s):

Hein Von Westernhagen ◽

Volkert Dethlefsen ◽

Harald Rosenthal

Keyword(s):

Drinking Water ◽

Hong Kong ◽

Bone Disease ◽

Sea Water ◽

Cadmium Concentration ◽

Kidney Damage ◽

Tissue Residue ◽

Pleuronectes Platessa ◽

Harbour Water ◽

Residue Levels

Although cadmium concentrations of unpolluted sea water are low, ranging from 0.01 to 0.41 µg/1 (Goldberg, 1965; Preston, 1973; Chester & Stoner, 1974; Kremling & Petersen, 1977) concentrations in estuaries are from 10 to 100 times higher, as reported by Butterworth, Lester & Nickless (1972) for the Severn and Eustace (1974) for the Derwent estuaries. Unusually high cadmium concentrations of 50 µg/1 have been found by Chan, Cheung & Li (1974) in Hong Kong harbour water. The cadmium in the drinking water (225 µ/l) and the food (rice) of Japanese farmers is believed to have caused the ‘itai-itai’ disease (Kobayashi, 1971), a pathological syndrome characterized by kidney damage with bone disease.

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