Progestin drives breast cancer growth by inducing p21CIP1 expression through the assembly of a transcriptional complex among Stat3, progesterone receptor and ErbB-2

Steroids ◽  
2013 ◽  
Vol 78 (6) ◽  
pp. 559-567 ◽  
Author(s):  
María C. Diaz Flaqué ◽  
Rocío Vicario ◽  
Cecilia J. Proietti ◽  
Franco Izzo ◽  
Roxana Schillaci ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Progesterone Receptor ◽  
Cancer Growth ◽  
Breast Cancer Growth ◽  
Transcriptional Complex

scholarly journals Antisense oligonucleotides targeting the progesterone receptor inhibit hormone-independent breast cancer growth in mice

2005 ◽  
Vol 7 (6) ◽  
Author(s):  
Caroline A Lamb ◽  
Luisa A Helguero ◽  
Sebastián Giulianelli ◽  
Rocío Soldati ◽  
Silvia I Vanzulli ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Progesterone Receptor ◽  
Antisense Oligonucleotides ◽  
Cancer Growth ◽  
Breast Cancer Growth

scholarly journals Progesterone Receptor Induces ErbB-2 Nuclear Translocation To Promote Breast Cancer Growth via a Novel Transcriptional Effect: ErbB-2 Function as a Coactivator of Stat3

2010 ◽  
Vol 30 (23) ◽  
pp. 5456-5472 ◽  
Author(s):  
Wendy Béguelin ◽  
María Celeste Díaz Flaqué ◽  
Cecilia J. Proietti ◽  
Florencia Cayrol ◽  
Martín A. Rivas ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Progesterone Receptor ◽  
Cyclin D1 ◽  
Nuclear Translocation ◽  
Breast Tumors ◽  
Promoter Activation ◽  
Transcriptional Effect ◽  
Breast Cancer Growth ◽  
Transcriptional Complex ◽  
Promote Breast Cancer

ABSTRACT Progesterone receptor (PR) and ErbB-2 bidirectional cross talk participates in breast cancer development. Here, we identified a new mechanism of the PR and ErbB-2 interaction involving the PR induction of ErbB-2 nuclear translocation and the assembly of a transcriptional complex in which ErbB-2 acts as a coactivator of Stat3. We also highlighted that the function of ErbB-2 as a Stat3 coactivator drives progestin-induced cyclin D1 promoter activation. Notably, PR is also recruited together with Stat3 and ErbB-2 to the cyclin D1 promoter, unraveling a new and unexpected nonclassical PR genomic mechanism. The assembly of the nuclear Stat3/ErbB-2 transcriptional complex plays a key role in the proliferation of breast tumors with functional PR and ErbB-2. Our findings reveal a novel therapeutic intervention for PR- and ErbB-2-positive breast tumors via the specific blockage of ErbB-2 nuclear translocation.

Progesterone receptor isoform ratio dictates antiprogestin/progestin effects on breast cancer growth and metastases: A role for NDRG1

2021 ◽  
Author(s):  
María Florencia Abascal ◽  
Andrés Elía ◽  
Michelle Alvarez ◽  
Gabriela Pataccini ◽  
Gonzalo Sequeira ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Progesterone Receptor ◽  
Cancer Growth ◽  
Breast Cancer Growth

Combined Treatment with Exendin-4 and Metformin Attenuates Breast Cancer Growth

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1227-P
Author(s):  
CHIKAYO IWAYA ◽  
TAKASHI NOMIYAMA ◽  
TAKAKO KAWANAMI ◽  
YURIKO HAMAGUCHI ◽  
TOMOKO TANAKA ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Combined Treatment ◽  
Cancer Growth ◽  
Breast Cancer Growth
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