Evaluation of vancomycin-based synergistic system with amino acid ester chiral ionic liquids as additives for enantioseparation of non-steroidal anti-inflamatory drugs by capillary electrophoresis

Talanta ◽  
2014 ◽  
Vol 119 ◽  
pp. 193-201 ◽  
Author(s):  
Jinjing Zhang ◽  
Yingxiang Du ◽  
Qi Zhang ◽  
Yuntao Lei
Keyword(s):  
Capillary Electrophoresis ◽  
Ionic Liquids ◽  
Amino Acid ◽  
Acid Ester ◽  
Amino Acid Ester ◽  
Chiral Ionic Liquids

Use of chiral amino acid ester-based ionic liquids as chiral selectors in CE

2013 ◽  
Vol 34 (4) ◽  
pp. 524-530 ◽  
Author(s):  
Ioannis J. Stavrou ◽  
Constantina P. Kapnissi-Christodoulou
Keyword(s):  
Ionic Liquids ◽  
Amino Acid ◽  
Acid Ester ◽  
Amino Acid Ester ◽  
Chiral Selectors

Amino acid chiral ionic liquids combined with hydroxypropyl-β-cyclodextrin for drug enantioseparation by capillary electrophoresis

2019 ◽  
Vol 1607 ◽  
pp. 460375 ◽  
Author(s):  
Sandra Salido-Fortuna ◽  
Maider Greño ◽  
María Castro-Puyana ◽  
María Luisa Marina
Keyword(s):  
Capillary Electrophoresis ◽  
Ionic Liquids ◽  
Amino Acid ◽  
Chiral Ionic Liquids

Equilibrium partitioning of drug molecules between aqueous and amino acid ester-based ionic liquids

2013 ◽  
Vol 62 ◽  
pp. 27-34 ◽  
Author(s):  
Jun Jing ◽  
Zhiyong Li ◽  
Yuanchao Pei ◽  
Huiyong Wang ◽  
Jianji Wang
Keyword(s):  
Ionic Liquids ◽  
Amino Acid ◽  
Acid Ester ◽  
Amino Acid Ester ◽  
Equilibrium Partitioning ◽  
Drug Molecules

scholarly journals The Proton Dissociation of Bio-Protic Ionic Liquids: [AAE]X Amino Acid Ionic Liquids

Molecules ◽  
2020 ◽  
Vol 26 (1) ◽  
pp. 62
Author(s):  
Ting He ◽  
Cheng-Bin Hong ◽  
Peng-Chong Jiao ◽  
Heng Xiang ◽  
Yan Zhang ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Amino Acid ◽  
Acid Ester ◽  
Amino Acid Ester ◽  
Acidity Function ◽  
Brønsted Acidity ◽  
Protic Ionic Liquids ◽  
Indicator Method ◽  
Pka Values ◽  
Brönsted Acidity

[AAE]X composed of amino acid ester cations is a sort of typically “bio-based” protic ionic liquids (PILs). They possess potential Brønsted acidity due to the active hydrogens on their cations. The Brønsted acidity of [AAE]X PILs in green solvents (water and ethanol) at room temperature was systematically studied. Various frameworks of amino acid ester cations and four anions were investigated in this work from the viewpoint of structure–property relationship. Four different ways were used to study the acidity. Acid dissociation constants (pKa) of [AAE]X determined by the OIM (overlapping indicator method) were from 7.10 to 7.73 in water and from 8.54 to 9.05 in ethanol. The pKa values determined by the PTM (potential titration method) were from 7.12 to 7.82 in water. Their Hammett acidity function (H0) values (0.05 mol·L−1) were about 4.6 in water. In addition, the pKa values obtained by the DFT (proton-transfer reactions) were from 7.11 to 7.83 in water and from 8.54 to 9.34 in ethanol, respectively. The data revealed that the cationic structures of [AAE]X had little effect and the anions had no effect on the acidity of [AAE]X. At the same time, the OIM, PTM, Hammett method and DFT method were reliable for determining the acidic strength of [AAE]X in this study.

Sign in / Sign up

Export Citation Format

Share Document