Synthesis of 4,8-anhydro-d-glycero-d-ido-nonanitol 1,6,7-trisphosphate as a novel IP3 receptor ligand using a stereoselective radical cyclization reaction based on a conformational restriction strategy

Tetrahedron ◽  
2005 ◽  
Vol 61 (15) ◽  
pp. 3697-3707 ◽  
Author(s):  
Masaru Terauchi ◽  
Yumi Yahiro ◽  
Hiroshi Abe ◽  
Satoshi Ichikawa ◽  
Stephen C. Tovey ◽  
...  
Keyword(s):  
Radical Cyclization ◽  
Cyclization Reaction ◽  
Ip3 Receptor ◽  
Conformational Restriction ◽  
Receptor Ligand ◽  
Restriction Strategy

Regioselective Synthesis of 2,3‐Dihydrobenzo[ f ]isoindolones via Ag‐Catalyzed Sequential Ugi 4CR/Cascade Radical Cyclization Reaction

2021 ◽  
Vol 363 (4) ◽  
pp. 1038-1043
Author(s):  
Ying‐Chun He ◽  
Yan‐Mei Yan ◽  
Zhen‐Xing Ren ◽  
Yong‐Zhao Wang ◽  
Qiang Yu ◽  
...  
Keyword(s):  
Radical Cyclization ◽  
Cyclization Reaction ◽  
Regioselective Synthesis

Rapid construction of the 6/6/5 tricyclic framework via a tandem radical cyclization reaction and its application to the synthesis of 5-epi-7-deoxy-isoabietenin A

2017 ◽  
Vol 4 (11) ◽  
pp. 2211-2215 ◽  
Author(s):  
Hao Zhang ◽  
Shiqiang Ma ◽  
Zhimin Xing ◽  
Lin Liu ◽  
Bowen Fang ◽  
...  
Keyword(s):  
Natural Products ◽  
Radical Cyclization ◽  
Cyclization Reaction ◽  
Rapid Construction

A tandem radical cyclization towards the 6/6/5 tricyclic skeleton, which exists in numerous natural products, was developed in modest to good yields.

Generation of tricyclic imidazo[1,2- a ]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy

2017 ◽  
Vol 27 (11) ◽  
pp. 2536-2543 ◽  
Author(s):  
Sonia Martínez González ◽  
Sonsoles Rodríguez-Arístegui ◽  
Ana Isabel Hernández ◽  
Carmen Varela ◽  
Esther González Cantalapiedra ◽  
...  
Keyword(s):  
Conformational Restriction ◽  
Pi3k Inhibitors ◽  
Restriction Strategy
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