Regioselective Synthesis of 2,3‐Dihydrobenzo[ f ]isoindolones via Ag‐Catalyzed Sequential Ugi 4CR/Cascade Radical Cyclization Reaction

2021 ◽  
Vol 363 (4) ◽  
pp. 1038-1043
Author(s):  
Ying‐Chun He ◽  
Yan‐Mei Yan ◽  
Zhen‐Xing Ren ◽  
Yong‐Zhao Wang ◽  
Qiang Yu ◽  
...  
Keyword(s):  
Radical Cyclization ◽  
Cyclization Reaction ◽  
Regioselective Synthesis

Radical-mediated cyclization reaction — Regioselective synthesis of pyrimidine- and coumarin-annulated [6,6]-fused oxygen heterocycles

2008 ◽  
Vol 86 (8) ◽  
pp. 846-854 ◽  
Author(s):  
Krishna C Majumdar ◽  
Pradip Debnath ◽  
Pradip K Maji
Keyword(s):  
Radical Cyclization ◽  
Cyclization Reaction ◽  
Regioselective Synthesis ◽  
Coumarin Derivatives ◽  
Aryl Radical ◽  
Pyrimidine Derivatives ◽  
Oxygen Heterocycles

The n-Bu3SnH-AIBN mediated aryl radical cyclization of various 8-[(2-bromophenoxy)methyl]-1,3-dimethyl-2,3,4,6-tetrahydro-1H-pyrano[3,2-d]pyrimidine-2,4-diones and 1-[(2-bromophenoxy)methyl]-3,5-dihydropyrano[2,3-c]coumarins was investigated with the formation of [6,6]-fused oxygen heterocycles as a single regioisomer.Key words: n-Bu3SnH-AIBN, aryl radical cyclization, 6-endo-trig, oxygen heterocycles, coumarin derivatives, pyrimidine derivatives.

Rapid construction of the 6/6/5 tricyclic framework via a tandem radical cyclization reaction and its application to the synthesis of 5-epi-7-deoxy-isoabietenin A

2017 ◽  
Vol 4 (11) ◽  
pp. 2211-2215 ◽  
Author(s):  
Hao Zhang ◽  
Shiqiang Ma ◽  
Zhimin Xing ◽  
Lin Liu ◽  
Bowen Fang ◽  
...  
Keyword(s):  
Natural Products ◽  
Radical Cyclization ◽  
Cyclization Reaction ◽  
Rapid Construction

A tandem radical cyclization towards the 6/6/5 tricyclic skeleton, which exists in numerous natural products, was developed in modest to good yields.

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