Introducing difluoromethylene sulfonamide group via nucleophilic addition of difluoromethylene anion with aromatic aldehydes

Tetrahedron ◽  
2007 ◽  
Vol 63 (4) ◽  
pp. 898-903 ◽  
Author(s):  
Jun-Li Li ◽  
Jin-Tao Liu
Keyword(s):  
Nucleophilic Addition ◽  
Aromatic Aldehydes ◽  
Sulfonamide Group

Magnesium salt promoted tandem nucleophilic addition–Oppenauer oxidation of aldehydes with organozinc reagents

2016 ◽  
Vol 14 (41) ◽  
pp. 9720-9724 ◽  
Author(s):  
Ying Fu ◽  
Xing Ling Zhao ◽  
Hulmet Hügel ◽  
Danfeng Huang ◽  
Zhengyin Du ◽  
...  
Keyword(s):  
Nucleophilic Addition ◽  
Aromatic Aldehydes ◽  
Magnesium Salt ◽  
Facile Synthesis ◽  
Aromatic Ketones ◽  
Oppenauer Oxidation ◽  
Organozinc Reagents

A facile synthesis of aromatic ketones via tandem nucleophilic addition–Oppenauer oxidation of aromatic aldehydes with organozinc reagents was demonstrated. Magnesium salt in situ generated via organozinc formation is a powerful promotor for this transformation.

scholarly journals Synthesis of indole–cycloalkyl[b]pyridine hybrids via a four-component six-step tandem process

2018 ◽  
Vol 14 ◽  
pp. 2907-2915 ◽  
Author(s):  
Muthumani Muthu ◽  
Rakkappan Vishnu Priya ◽  
Abdulrahman I Almansour ◽  
Raju Suresh Kumar ◽  
Raju Ranjith Kumar
Keyword(s):  
Michael Addition ◽  
Nucleophilic Addition ◽  
Ammonium Acetate ◽  
Knoevenagel Condensation ◽  
Aromatic Aldehydes ◽  
Air Oxidation ◽  
One Pot ◽  
Tandem Process ◽  
The One

The one-pot four-component reaction of 3-(1H-indol-3-yl)-3-oxopropanenitriles, aromatic aldehydes, cycloalkanones and ammonium acetate occurred via a six-step tandem Knoevenagel condensation–nucleophilic addition to carbonyl–Michael addition–N-cyclization–elimination–air oxidation sequence to afford structurally intriguing indole–cycloalkyl[b]pyridine-3-carbonitrile hybrid heterocycles in excellent yields.

Tandem nucleophilic addition–Oppenauer oxidation of aromatic aldehydes to aryl ketones with triorganoaluminium reagents

2013 ◽  
Vol 11 (27) ◽  
pp. 4429 ◽  
Author(s):  
Ying Fu ◽  
Yanshou Yang ◽  
Helmut M. Hügel ◽  
Zhengyin Du ◽  
Kehu Wang ◽  
...  
Keyword(s):  
Nucleophilic Addition ◽  
Aromatic Aldehydes ◽  
Aryl Ketones ◽  
Oppenauer Oxidation
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