Plasma D-dimer and abdominal aortic aneurysm

2010 ◽  
Vol 126 (6) ◽  
pp. e451-e452
Author(s):  
Hisato Takagi ◽  
Hideaki Manabe ◽  
Masafumi Matsui ◽  
Shin-nosuke Goto ◽  
Takuya Umemoto
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Abdominal Aortic ◽  
D Dimer

Compensated activation of coagulation in patients with abdominal aortic aneurysm: effects of heparin treatment prior to elective surgery

2004 ◽  
Vol 92 (11) ◽  
pp. 997-1002 ◽  
Author(s):  
Jacek Szmidt ◽  
Krzystof Bojakowski ◽  
Tomasz Grzela ◽  
Magorzata Palester-Chlebowczyk ◽  
Maria Jelenska
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Reference Group ◽  
Elective Surgery ◽  
Operation Time ◽  
Fibrinogen Concentration ◽  
Excessive Bleeding ◽  
Prothrombin Fragment ◽  
Abdominal Aortic ◽  
D Dimer

SummaryElective surgery of abdominal aortic aneurysm (AAA) sometimes leads to excessive bleeding and disseminated intravascular coagulation (DIC), even in patients with normal preoperative coagulation parameters. Coagulation screen, performed routinely before surgery is of limited value in the assessment of compensated activation of the haemostatic system. In this study, we used a number of additional tests (D-dimer, prothrombin fragment 1+2, antithrombin, and activation of fibrinolysis in the platelet poor plasma) for the diagnosis of compensated activation of the haemostatic system in AAA-patients. Ddimer and marker of thrombin generation (prothrombin fragment 1+2) positively correlated with each other (r = 0.768, P < 0.001). Out of 71 AAA patients, 15 patients had normal global coagulation times, but those with a Ddimer concentration above 3000 ng/ml were selected for preoperative low molecular weight heparin (LMWH) treatment. Administration of LMWH diminished coagulation abnormalities (D-dimer and prothrombin fragment 1+2 decreased significantly) and resulted in the increase of platelet number and fibrinogen concentration, indicating their previous consumption. Despite differences in aneurysm diameters between the groups of 15 LMWH treated patients (mean 70.9 ± 16 mm) and the reference group of 20 untreated AAA patients (mean 52.3 ± 8.0 mm), intraoperative parameters (operation time, blood loss and transfusion demands) were similar.

Plasma D-dimer as a predictor of the progression of abdominal aortic aneurysm

2016 ◽  
Vol 14 (11) ◽  
pp. 2298-2303 ◽  
Author(s):  
E. Vele ◽  
A. Kurtcehajic ◽  
E. Zerem ◽  
J. Maskovic ◽  
E. Alibegovic ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Abdominal Aortic ◽  
D Dimer

Interplay between Coagulation and Inflammation in Open and Endovascular Abdominal Aortic Aneurysm Repair — Impact of Intra-Aneurysmal Thrombus

2007 ◽  
Vol 96 (3) ◽  
pp. 229-235 ◽  
Author(s):  
P.-S. Aho ◽  
T. Niemi ◽  
A. Piilonen ◽  
R. Lassila ◽  
R. Renkonen ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Abdominal Aortic Aneurysm Repair ◽  
Open Group ◽  
Intraluminal Thrombus ◽  
Computed Tomography Images ◽  
Abdominal Aortic ◽  
Aneurysm Repair ◽  
Aortic Aneurysm Repair ◽  
D Dimer

Aims: Our aim was to compare hemostatic and inflammatory mechanisms in abdominal aortic aneurysm (AAA) patients after open surgery (OPEN) and endovascular AAA repair (ENDO). Subjects and Methods: From the 32 consecutive AAA patients recruited, 17 represented ENDO and 15 OPEN. The intra-aneurysmal thrombus was removed during OPEN, but stayed intact after ENDO. The pre-operative volume of the intra-aneurysmal thrombus was calculated from computed tomography images. Markers of coagulation and inflammation were studied pre-operatively, at one, two, three, four and seven days and at three months postoperatively. Results: Preoperative upregulation of F 1 + 2, TAT and D-dimer was evident in both groups. The volume of intra-aneurysmal thrombus correlated with CRP (β=0.62, p=0.001), IL-6 (β=0.60, p=0.001) and PAI-1 ag (β=0.51, p=0.007). Surgery further enhanced inflammation, coagulation and fibrinolysis. IL-6 increased in both groups, but the increases of CRP and PIIINP were higher in the OPEN group. Postoperative CRP correlated with the intra-aneurysmal thrombus volume in the ENDO group. At three months D-dimer (p<0.05) was higher than pre-operatively in the ENDO, in contrast to the OPEN group. Conclusion: Preoperatively both prothrombotic and fibrinolytic mechanisms are activated in patients with AAA. Intraluminal thrombus induces prothrombotic and inflammatory interactions, which persist after endovascular aortic aneurysm repair.

Plasma D-dimer as a predictor of intraluminal thrombus burden and progression of abdominal aortic aneurysm

Life Sciences ◽  
2020 ◽  
Vol 240 ◽  
pp. 117069
Author(s):  
Ying-nan Fan ◽  
Xiao Ke ◽  
Zhi-long Yi ◽  
Yong-qing Lin ◽  
Bing-qing Deng ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Intraluminal Thrombus ◽  
Abdominal Aortic ◽  
D Dimer

scholarly journals Evaluation of the diagnostic and prognostic value of plasma D-dimer for abdominal aortic aneurysm

2010 ◽  
Vol 32 (3) ◽  
pp. 354-364 ◽  
Author(s):  
J. Golledge ◽  
R. Muller ◽  
P. Clancy ◽  
M. McCann ◽  
P. E. Norman
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Prognostic Value ◽  
Abdominal Aortic ◽  
Diagnostic And Prognostic Value ◽  
D Dimer

scholarly journals Prognostic value of D-dimer and markers of coagulation for stratification of abdominal aortic aneurysm growth

2018 ◽  
Vol 2 (22) ◽  
pp. 3088-3096 ◽  
Author(s):  
Alexandra C. Sundermann ◽  
Keith Saum ◽  
Kelsey A. Conrad ◽  
Hannah M. Russell ◽  
Todd L. Edwards ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Prognostic Value ◽  
High Morbidity ◽  
Platelet Factor ◽  
Fast Growing ◽  
Abdominal Aortic ◽  
Aneurysm Growth ◽  
Slow Growing ◽  
D Dimer

Abstract Abdominal aortic aneurysm (AAA) is associated with high morbidity and mortality and is an established cause of unbalanced hemostasis. A number of hemostatic biomarkers have been associated with AAA; however, the utility of hemostatic biomarkers in AAA diagnosis and prognosis is unclear. The aim of the present study was to characterize the potential prognostic value of D-dimer and markers of altered hemostasis in a large cohort of patients with AAAs characterized by either fast or slow aneurysm growth (frequency matched for baseline diameter) and subaneurysmal dilations. We measured plasma concentrations of thrombin-antithrombin (TAT) complex, platelet factor 4 (PF4), and D-dimer in 352 patients with either fast-growing AAAs (&gt;2 mm/y), slow-growing AAAs (&lt;2 mm/y), subaneurysmal aortic dilations, or nonaneurysmal aortas. Plasma D-dimer and TAT were significantly elevated in both AAA and subaneurysmal dilation patients compared with controls. Individuals with D-dimer levels ≥500 ng/mL had 3.09 times the odds of subaneurysms, 6.23 times the odds of slow-growing AAAs, and 7.19 times the odds of fast-growing AAAs than individuals with D-dimer level &lt;500 ng/mL. However, no differences in D-dimer concentration were noted between fast- and slow-growing aneurysms. Plasma D-dimer and TAT were strong independent predictors of AAA growth rate with multivariate analysis revealing a 500-ng/mL increase in D-dimer or 1-µg/mL increase in TAT led to additional 0.21-mm and 0.24-mm changes in aortic diameter per year, respectively. Rising levels of plasma TAT, in addition to D-dimer, may predict disease progression and aneurysm growth in patients with AAA or subaneurysmal dilation.

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