Plasma D-dimer as a predictor of intraluminal thrombus burden and progression of abdominal aortic aneurysm

Life Sciences ◽  
2020 ◽  
Vol 240 ◽  
pp. 117069
Author(s):  
Ying-nan Fan ◽  
Xiao Ke ◽  
Zhi-long Yi ◽  
Yong-qing Lin ◽  
Bing-qing Deng ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Intraluminal Thrombus ◽  
Abdominal Aortic ◽  
D Dimer

Interplay between Coagulation and Inflammation in Open and Endovascular Abdominal Aortic Aneurysm Repair — Impact of Intra-Aneurysmal Thrombus

2007 ◽  
Vol 96 (3) ◽  
pp. 229-235 ◽  
Author(s):  
P.-S. Aho ◽  
T. Niemi ◽  
A. Piilonen ◽  
R. Lassila ◽  
R. Renkonen ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Abdominal Aortic Aneurysm Repair ◽  
Open Group ◽  
Intraluminal Thrombus ◽  
Computed Tomography Images ◽  
Abdominal Aortic ◽  
Aneurysm Repair ◽  
Aortic Aneurysm Repair ◽  
D Dimer

Aims: Our aim was to compare hemostatic and inflammatory mechanisms in abdominal aortic aneurysm (AAA) patients after open surgery (OPEN) and endovascular AAA repair (ENDO). Subjects and Methods: From the 32 consecutive AAA patients recruited, 17 represented ENDO and 15 OPEN. The intra-aneurysmal thrombus was removed during OPEN, but stayed intact after ENDO. The pre-operative volume of the intra-aneurysmal thrombus was calculated from computed tomography images. Markers of coagulation and inflammation were studied pre-operatively, at one, two, three, four and seven days and at three months postoperatively. Results: Preoperative upregulation of F 1 + 2, TAT and D-dimer was evident in both groups. The volume of intra-aneurysmal thrombus correlated with CRP (β=0.62, p=0.001), IL-6 (β=0.60, p=0.001) and PAI-1 ag (β=0.51, p=0.007). Surgery further enhanced inflammation, coagulation and fibrinolysis. IL-6 increased in both groups, but the increases of CRP and PIIINP were higher in the OPEN group. Postoperative CRP correlated with the intra-aneurysmal thrombus volume in the ENDO group. At three months D-dimer (p<0.05) was higher than pre-operatively in the ENDO, in contrast to the OPEN group. Conclusion: Preoperatively both prothrombotic and fibrinolytic mechanisms are activated in patients with AAA. Intraluminal thrombus induces prothrombotic and inflammatory interactions, which persist after endovascular aortic aneurysm repair.

Compensated activation of coagulation in patients with abdominal aortic aneurysm: effects of heparin treatment prior to elective surgery

2004 ◽  
Vol 92 (11) ◽  
pp. 997-1002 ◽  
Author(s):  
Jacek Szmidt ◽  
Krzystof Bojakowski ◽  
Tomasz Grzela ◽  
Magorzata Palester-Chlebowczyk ◽  
Maria Jelenska
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Reference Group ◽  
Elective Surgery ◽  
Operation Time ◽  
Fibrinogen Concentration ◽  
Excessive Bleeding ◽  
Prothrombin Fragment ◽  
Abdominal Aortic ◽  
D Dimer

SummaryElective surgery of abdominal aortic aneurysm (AAA) sometimes leads to excessive bleeding and disseminated intravascular coagulation (DIC), even in patients with normal preoperative coagulation parameters. Coagulation screen, performed routinely before surgery is of limited value in the assessment of compensated activation of the haemostatic system. In this study, we used a number of additional tests (D-dimer, prothrombin fragment 1+2, antithrombin, and activation of fibrinolysis in the platelet poor plasma) for the diagnosis of compensated activation of the haemostatic system in AAA-patients. Ddimer and marker of thrombin generation (prothrombin fragment 1+2) positively correlated with each other (r = 0.768, P < 0.001). Out of 71 AAA patients, 15 patients had normal global coagulation times, but those with a Ddimer concentration above 3000 ng/ml were selected for preoperative low molecular weight heparin (LMWH) treatment. Administration of LMWH diminished coagulation abnormalities (D-dimer and prothrombin fragment 1+2 decreased significantly) and resulted in the increase of platelet number and fibrinogen concentration, indicating their previous consumption. Despite differences in aneurysm diameters between the groups of 15 LMWH treated patients (mean 70.9 ± 16 mm) and the reference group of 20 untreated AAA patients (mean 52.3 ± 8.0 mm), intraoperative parameters (operation time, blood loss and transfusion demands) were similar.

Multimodality imaging assessment of the deleterious role of the intraluminal thrombus on the growth of abdominal aortic aneurysm in a rat model

2015 ◽  
Vol 26 (7) ◽  
pp. 2378-2386 ◽  
Author(s):  
Alain Nchimi ◽  
Audrey Courtois ◽  
Mounia El Hachemi ◽  
Ziad Touat ◽  
Pierre Drion ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Rat Model ◽  
Multimodality Imaging ◽  
Intraluminal Thrombus ◽  
Abdominal Aortic

Plasma D-dimer as a predictor of the progression of abdominal aortic aneurysm

2016 ◽  
Vol 14 (11) ◽  
pp. 2298-2303 ◽  
Author(s):  
E. Vele ◽  
A. Kurtcehajic ◽  
E. Zerem ◽  
J. Maskovic ◽  
E. Alibegovic ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Abdominal Aortic ◽  
D Dimer

Intraluminal thrombus and risk of rupture in patient specific abdominal aortic aneurysm – FSI modelling

2009 ◽  
Vol 12 (1) ◽  
pp. 73-81 ◽  
Author(s):  
Danny Bluestein ◽  
Kris Dumont ◽  
Matthieu De Beule ◽  
John Ricotta ◽  
Paul Impellizzeri ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Patient Specific ◽  
Intraluminal Thrombus ◽  
Abdominal Aortic ◽  
Risk Of Rupture

Investigating the Effect of Intraluminal Thrombus in Abdominal Aortic Aneurysm by Computational and Experimental Methods

2009 ◽  
Author(s):  
Florentina Ene ◽  
Carine Gachon ◽  
Patrick Delassus ◽  
Liam Morris
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
High Risk ◽  
Aortic Aneurysm ◽  
Abdominal Aorta ◽  
Experimental Methods ◽  
Infrarenal Aorta ◽  
Intraluminal Thrombus ◽  
Abdominal Aortic ◽  
Risk Of Rupture

Abdominal aortic aneurysm (AAA) represents an abnormal dilatation and weakening of the abdominal aorta with high risk of rupture. Most aneurysms of the infrarenal aorta possess an asymmetrical fusiform morphology.

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