Rivaroxaban attenuates leukocyte adhesion in the microvasculature and thrombus formation in an experimental mouse model of type 2 diabetes mellitus

2014 ◽  
Vol 133 (2) ◽  
pp. 276-280 ◽  
Author(s):  
Toshiaki Iba ◽  
Koichiro Aihara ◽  
Atushi Yamada ◽  
Masataka Nagayama ◽  
Yoko Tabe ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Mouse Model ◽  
Leukocyte Adhesion ◽  
Thrombus Formation ◽  
Experimental Mouse Model ◽  
Experimental Mouse

Co-Purification of Recombinant Modified Glucagon-Like and Glucose-Dependent Insulinotropic Peptide to Create a Two-Component Drug for the Treatment of Type 2 Diabetes Mellitus and Obesity

2021 ◽  
Vol 37 (6) ◽  
pp. 74-83
Author(s):  
A.Yu. Gorbunova ◽  
E.P. Sannikova ◽  
I.I. Gubaidullin ◽  
O.M. Ignatova ◽  
M.Yu. Kopaeva ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Mouse Model ◽  
Specific Activity ◽  
Two Component ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Insulinotropic Peptide

In addition to the previously developed recombinant modified human glucagon-like peptide 1 (rmglp1, Glypin), a recombinant modified human glucose-dependent insulinotropic peptide (RMGIP) has been obtained. A new universal reverse-phase HPLC technique has been proposed allowing quantitative analysis of rmGlp1 and rmGip separately and as part of a two-component preparation. The data show that the design of recombinant human rmGip according to the Glypine formula makes it possible to produce one-component and two-component preparations containing various rmGip and rmGlp1 protein ratios ranging from 1:0 to 20:1, using cell biomass samples mixed in predetermined proportions. Studies of human rmGip activity in a mouse model revealed reduced specific activity and signs of weak antagonistic effects. In this regard, there is a need for further study of human rmGip activity in a mouse model, including the use of alternative mouse or rat rmGip. type 2 diabetes mellitus; two-component drug, glucose-dependent insulinotropic peptide, glucagon-like peptide-1 The work was supported by the Internal Grant from National Research Center Kurchatov Institute.

scholarly journals Recombinant Human Insulin-Like Growth Factor-I Treatment Inhibits Gluconeogenesis in a Transgenic Mouse Model of Type 2 Diabetes Mellitus

Endocrinology ◽  
2006 ◽  
Vol 147 (6) ◽  
pp. 2619-2630 ◽  
Author(s):  
Patricia Pennisi ◽  
Oksana Gavrilova ◽  
Jennifer Setser-Portas ◽  
William Jou ◽  
Stefania Santopietro ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Growth Factor ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Recombinant Human Insulin ◽  
Factor I

scholarly journals Type 2 Diabetes Mellitus in Obese Mouse Model Induced by Monosodium Glutamate

2006 ◽  
Vol 55 (2) ◽  
pp. 109-115 ◽  
Author(s):  
Mitsunobu NAGATA ◽  
Wataru SUZUKI ◽  
Seiichi IIZUKA ◽  
Masahiro TABUCHI ◽  
Hirofumi MARUYAMA ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Mouse Model ◽  
Monosodium Glutamate ◽  
Obese Mouse

scholarly journals Apolipoprotein E deficiency abrogates insulin resistance in a mouse model of type 2 diabetes mellitus

Diabetologia ◽  
2009 ◽  
Vol 52 (7) ◽  
pp. 1434-1441 ◽  
Author(s):  
Y. Kawashima ◽  
J. Chen ◽  
H. Sun ◽  
D. Lann ◽  
R. J. Hajjar ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Mouse Model ◽  
Apolipoprotein E

scholarly journals Rosiglitazone Influences the Expression of Leukocyte Adhesion Molecules and CD14 Receptor in Type 2 Diabetes Mellitus Patients

2014 ◽  
pp. S293-S298 ◽  
Author(s):  
T. ŠTULC ◽  
H. SVOBODOVÁ ◽  
Z. KRUPIČKOVÁ ◽  
R. DOLEŽALOVÁ ◽  
I. MARINOV ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Adhesion Molecules ◽  
Leukocyte Adhesion ◽  
Surface Expression ◽  
Receptor Expression ◽  
Rosiglitazone Treatment ◽  
Leukocyte Adhesion Molecules

Diabetes mellitus is associated with increased inflammatory response, which may contribute to atherosclerosis progression. Experimental results demonstrated anti-inflammatory activity of glitazones; their effect on leukocyte adhesion molecules has not been studied to date. We therefore studied the effect of rosiglitazone treatment on leukocyte surface expression of adhesion molecules in patients with type 2 diabetes mellitus and compared our results with findings in healthy subjects. 33 subjects with type 2 diabetes and 32 healthy controls were included; patients were examined at baseline and after 5 months of rosiglitazone treatment (4 mg/d). Leukocyte expression of adhesion molecules LFA-1, CD18 and ICAM-1 was quantified using flow cytometry; in addition, CD14 (lipopolysaccharide receptor) expression was analyzed as a marker of nonspecific immunity. The expression of examined molecules at baseline was higher in patients compared to controls. Despite only mild decrease in blood glucose, rosiglitazone treatment induced substantial decrease of CD18 and CD14 expression and borderline decrease of LFA-1 and ICAM-1 expression (on monocytes only). We thus observed improvement in the expression of leukocyte inflammatory markers after rosiglitazone treatment. This effect is supposed to be mediated by direct effect of rosiglitazone on PPAR-γ receptors on leukocytes.

scholarly journals Pleiotropic effects of metformin in managing type 2 diabetes and metabolic syndrome: evidences from experimental mouse model

2018 ◽  
Vol 29 (17) ◽  
Author(s):  
Christina Gertrude Yap ◽  
Rakesh Naidu ◽  
Kim Dae Jin ◽  
Srinivasa Rao Sirasanagandla ◽  
Narendra Pamidi
Keyword(s):  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Mouse Model ◽  
Pleiotropic Effects ◽  
Experimental Mouse Model ◽  
Experimental Mouse

scholarly journals P4-522: TYPE 2 DIABETES MELLITUS INDUCES TAU-INDEPENDENT COGNITIVE AND SYNAPTIC DEFICITS IN A MOUSE MODEL

2019 ◽  
Vol 15 ◽  
pp. P1514-P1514
Author(s):  
Laura Trujillo-Estrada ◽  
Run R. Kuang ◽  
Celia Da Cunha ◽  
Stefania Forner ◽  
Alessandra Cadete Martini ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Mouse Model
Sign in / Sign up

Export Citation Format

Share Document