Genetic diseases associated with heterotrimeric G proteins

2006 ◽  
Vol 27 (5) ◽  
pp. 260-266 ◽  
Author(s):  
Lee S. Weinstein ◽  
Min Chen ◽  
Tao Xie ◽  
Jie Liu
Keyword(s):  
G Proteins ◽  
Genetic Diseases ◽  
Heterotrimeric G Proteins

scholarly journals Olfactory desensitization requires membrane targeting of receptor kinase mediated by beta gamma-subunits of heterotrimeric G proteins.

1994 ◽  
Vol 269 (1) ◽  
pp. 37-40
Author(s):  
I. Boekhoff ◽  
J. Inglese ◽  
S. Schleicher ◽  
W.J. Koch ◽  
R.J. Lefkowitz ◽  
...  
Keyword(s):  
G Proteins ◽  
Membrane Targeting ◽  
Heterotrimeric G Proteins ◽  
Receptor Kinase ◽  
Gamma Subunits

scholarly journals Every Detail Matters. That Is, How the Interaction between Gα Proteins and Membrane Affects Their Function

Membranes ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 222
Author(s):  
Agnieszka Polit ◽  
Paweł Mystek ◽  
Ewa Błasiak
Keyword(s):  
Signal Transduction ◽  
G Protein ◽  
G Proteins ◽  
Lipid Membranes ◽  
Signaling Proteins ◽  
Heterotrimeric G Proteins ◽  
Membrane Attachment ◽  
The Individual ◽  
Multicellular Organisms ◽  
G Protein Coupled

In highly organized multicellular organisms such as humans, the functions of an individual cell are dependent on signal transduction through G protein-coupled receptors (GPCRs) and subsequently heterotrimeric G proteins. As most of the elements belonging to the signal transduction system are bound to lipid membranes, researchers are showing increasing interest in studying the accompanying protein–lipid interactions, which have been demonstrated to not only provide the environment but also regulate proper and efficient signal transduction. The mode of interaction between the cell membrane and G proteins is well known. Despite this, the recognition mechanisms at the molecular level and how the individual G protein-membrane attachment signals are interrelated in the process of the complex control of membrane targeting of G proteins remain unelucidated. This review focuses on the mechanisms by which mammalian Gα subunits of G proteins interact with lipids and the factors responsible for the specificity of membrane association. We summarize recent data on how these signaling proteins are precisely targeted to a specific site in the membrane region by introducing well-defined modifications as well as through the presence of polybasic regions within these proteins and interactions with other components of the heterocomplex.

scholarly journals Shuttling and translocation of heterotrimeric G proteins and Ras

2009 ◽  
Vol 30 (6) ◽  
pp. 278-286 ◽  
Author(s):  
Deepak K. Saini ◽  
Mariangela Chisari ◽  
N. Gautam
Keyword(s):  
G Proteins ◽  
Heterotrimeric G Proteins

scholarly journals Ligand-triggered de-repression of Arabidopsis heterotrimeric G proteins coupled to immune receptor kinases

Cell Research ◽  
2018 ◽  
Vol 28 (5) ◽  
pp. 529-543 ◽  
Author(s):  
Xiangxiu Liang ◽  
Miaomiao Ma ◽  
Zhaoyang Zhou ◽  
Jinlong Wang ◽  
Xinru Yang ◽  
...  
Keyword(s):  
G Proteins ◽  
Heterotrimeric G Proteins ◽  
Immune Receptor ◽  
Receptor Kinases

scholarly journals Signaling from G Protein-coupled Receptors to ERK5/Big MAPK 1 Involves Gαqand Gα12/13Families of Heterotrimeric G Proteins

2000 ◽  
Vol 275 (28) ◽  
pp. 21730-21736 ◽  
Author(s):  
Shigetomo Fukuhara ◽  
Maria Julia Marinissen ◽  
Mario Chiariello ◽  
J. Silvio Gutkind
Keyword(s):  
G Protein ◽  
G Proteins ◽  
G Protein Coupled Receptors ◽  
Heterotrimeric G Proteins ◽  
G Protein Coupled

Biochemical and genetic evidence for a family of heterotrimeric G-proteins in Trichomonas vaginalis

2003 ◽  
Vol 129 (2) ◽  
pp. 179-189 ◽  
Author(s):  
R.P Hirt ◽  
K Lal ◽  
J Pinxteren ◽  
J Warwicker ◽  
B Healy ◽  
...  
Keyword(s):  
G Proteins ◽  
Trichomonas Vaginalis ◽  
Genetic Evidence ◽  
Heterotrimeric G Proteins

Membrane-bound and cytosolic forms of heterotrimeric G proteins in young and adult rat myocardium: Influence of neonatal hypo- and hyperthyroidism

2001 ◽  
Vol 82 (2) ◽  
pp. 215-224 ◽  
Author(s):  
Jiri Novotny ◽  
Lenka Bouřová ◽  
František Kolář ◽  
Petr Svoboda
Keyword(s):  
G Proteins ◽  
Rat Myocardium ◽  
Heterotrimeric G Proteins ◽  
Adult Rat ◽  
Membrane Bound
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