scholarly journals Up-regulation of CYP1A/B in rat lung and liver, and human liver precision-cut slices by a series of polycyclic aromatic hydrocarbons; association with the Ah locus and importance of molecular size

2008 ◽  
Vol 22 (1) ◽  
pp. 128-145 ◽  
Author(s):  
Daphnee S. Pushparajah ◽  
Meera Umachandran ◽  
Tariq Nazir ◽  
Kathryn E. Plant ◽  
Nick Plant ◽  
...  
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Aromatic Hydrocarbons ◽  
Human Liver ◽  
Molecular Size ◽  
Rat Lung ◽  
Polycyclic Aromatic

Binding of natural humic matter to polycyclic aromatic hydrocarbons in rivers of the Southeastern United States

1994 ◽  
Vol 30 (10) ◽  
pp. 199-205 ◽  
Author(s):  
James J. Alberts ◽  
Cheryl Griffin ◽  
Katherine Gwynne ◽  
Gordon J. Leversee
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Humic Acids ◽  
Aromatic Hydrocarbons ◽  
Southeastern United States ◽  
Binding Constants ◽  
Molecular Size ◽  
Fulvic Acids ◽  
Humic Matter ◽  
Polycyclic Aromatic ◽  
Molecular Size Distribution

The binding constants (Koc) of four polycyclic aromatic hydrocarbons (PAH) were determined for sedimentary fulvic and humic acids and the dissolved organic carbon (DOC) of five rivers in Georgia, USA. The log Koc for the PAH ranged: anthracene, 4.63-5.57; phenanthrene, 4.58-5.62; pyrene, 4.90-5.65; benzo(a)pyrene, 3.48-5.20. Log Koc values for the PAH compounds with riverine DOC were very similar for all rivers and more closely resembled those of sedimentary humic acids than the fulvic acids. The molecular size distribution of the riverine DOC indicates that >75% of the DOC occurs in size fractions >10,000 daltons. Despite similarities in Koc, there appear to be inter-river differences in the distribution of PAH among molecular size classes of the DOC, which have ramifications for water quality both in rivers and estuaries.

Elution of Polycyclic Aromatic Hydrocarbons From Carbon Blacks Into Biomembranes in Vitro

1985 ◽  
Vol 1 (1) ◽  
pp. 57-67 ◽  
Author(s):  
David R. Bevan ◽  
Nancy T. Yonda
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Carbon Black ◽  
Aromatic Hydrocarbons ◽  
Lung Surfactant ◽  
Rat Lung ◽  
Carbon Blacks ◽  
P Content ◽  
Dimyristoyl Phosphatidylcholine ◽  
Polycyclic Aromatic

Elution of endogenous polycyclic aromatic hydrocarbons (PAH) from four carbon blacks into biomembranes was investigated in vitro. Membrane systems employed were phospholipid vesicles composed of dimyristoyl phosphatidylcholine (DMPC), rat lung homogenate, and simulated lung surfactant. Amounts of benzo[a]-pyrene which were eluted from carbon blacks were not dependent on the type of membrane, but elution was dependent on the type of carbon black. Elution of B[a]P was detected from only 2 of the carbon blacks and amounts eluted represented only 0.2% to 0.6% of total B[a]P associated with those carbon blacks. The largest amount of B[a]P was eluted from the carbon black with lowest surface area and highest endogenous B[a]P content. Benzo[ghi]perylene also was eluted from carbon blacks though amounts eluted again represented extremely small fractions (0.1-0.2%) of the total on the particles. From these experiments, it appears that only very small quantities of B[a]P and other PAH on carbon blacks are bioavailable.

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