Step towards a hepatotoxicity warning system: Assessment of drug-induced liver injury risk by applying conformal predictions and chemical substructure alerts

2015 ◽  
Vol 238 (2) ◽  
pp. S168
Author(s):  
T. Noeske ◽  
E. Ahlberg
Keyword(s):  
Liver Injury ◽  
Injury Risk ◽  
Warning System ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
System Assessment

New Perspectives on Drug-Induced Liver Injury Risk Assessment of Acyl Glucuronides

2020 ◽  
Vol 33 (7) ◽  
pp. 1551-1560 ◽  
Author(s):  
Markus Walles ◽  
Alan P. Brown ◽  
Alfred Zimmerlin ◽  
Peter End
Keyword(s):  
Risk Assessment ◽  
Liver Injury ◽  
Injury Risk ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Acyl Glucuronides

In vitro assessment of farnesoid X receptor antagonism to predict drug-induced liver injury risk

2020 ◽  
Vol 94 (9) ◽  
pp. 3185-3200
Author(s):  
Leah M. Norona ◽  
Aaron Fullerton ◽  
Chris Lawson ◽  
Leslie Leung ◽  
Jochen Brumm ◽  
...  
Keyword(s):  
Liver Injury ◽  
Injury Risk ◽  
Farnesoid X Receptor ◽  
Drug Induced ◽  
Receptor Antagonism ◽  
Drug Induced Liver Injury ◽  
In Vitro Assessment

A modified multiparametric assay using HepaRG cells for predicting the degree of drug-induced liver injury risk

2016 ◽  
Vol 37 (3) ◽  
pp. 382-390 ◽  
Author(s):  
Takafumi Tomida ◽  
Hayao Okamura ◽  
Tsuyoshi Yokoi ◽  
Yoshihiro Konno
Keyword(s):  
Liver Injury ◽  
Injury Risk ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Heparg Cells

Assessment of Serious Acute and Chronic Idiosyncratic Drug-Induced Liver Injury in Clinical Practice

2019 ◽  
Vol 39 (03) ◽  
pp. 381-394 ◽  
Author(s):  
Fernando Bessone ◽  
Mercedes Robles-Diaz ◽  
Nelia Hernandez ◽  
Inmaculada Medina-Caliz ◽  
M. Isabel Lucena ◽  
...  
Keyword(s):  
Liver Injury ◽  
Injury Risk ◽  
Acute Liver Injury ◽  
Developed Countries ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Injury Risk Factors ◽  
Variable Phenotype ◽  
Hy’S Law ◽  
Scoring Algorithms

AbstractDrug-induced liver injury (DILI) is the leading cause of acute liver failure (ALF) in developed countries. The extremely variable phenotype of DILI, both in presentation and in severity, is one of the distinctive characteristics of the disease and one of the major challenges that hepatologists face when assessing hepatotoxicity cases. A new Hy's law that more accurately predicts the risk of ALF related to DILI has been proposed and validated. Other prognostic scoring algorithms for the early identification of DILI patients who may go on to develop ALF have been developed as it is of most clinical relevance to stratify patients for closer monitoring. Recent data indicate that acute DILI often presents a more prolonged resolution or evolves into chronicity at a higher frequency than other forms of acute liver injury. Risk factors for chronicity, specific phenotypes, and histological features are discussed in this study. Biomarkers to predict DILI outcome are in need.

Leberschaden unter oraler Antikoagulation, Statin- und ACE-Hemmertherapie

Praxis ◽  
2010 ◽  
Vol 99 (21) ◽  
pp. 1259-1265 ◽  
Author(s):  
Bruggisser ◽  
Terraciano ◽  
Rätz Bravo ◽  
Haschke
Keyword(s):  
Liver Injury ◽  
Wird Eine ◽  
Drug Induced ◽  
Drug Induced Liver Injury

Ein 71-jähriger Patient stellt sich mit Epistaxis und ikterischen Skleren auf der Notfallstation vor. Der Patient steht unter einer Therapie mit Phenprocoumon, Atorvastatin und Perindopril. Anamnestisch besteht ein langjähriger Alkoholabusus. Laborchemisch werden massiv erhöhte Leberwerte (ALAT, Bilirubin) gesehen. Der INR ist unter oraler Antikoagulation und bei akuter Leberinsuffizienz >12. Die weiterführenden Abklärungen schliessen eine Virushepatitis und eine Autoimmunhepatitis aus. Nachdem eine Leberbiopsie durchgeführt werden kann, wird eine medikamentös-toxische Hepatitis, ausgelöst durch die Komedikation von Atorvastatin, Phenprocoumon und Perindopril bei durch Alkohol bereits vorgeschädigter Leber diagnostiziert. Epidemiologie, Pathophysiologie und Klink der medikamentös induzierten Leberschäden (drug induced liver injury, DILI), speziell von Coumarinen, Statinen und ACE-Hemmern werden im Anschluss an den Fallbericht diskutiert.

Drug-induced liver injury network (DILIN)

Hepatology ◽  
2004 ◽  
Vol 40 (4) ◽  
pp. 773-773 ◽  
Author(s):  
Jay H. Hoofnagle
Keyword(s):  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury

Drug induced liver injury associated with Flupirtine in 6 cases

2011 ◽  
Vol 49 (08) ◽  
Author(s):  
C Agne ◽  
K Rifai ◽  
HH Kreipe ◽  
MP Manns ◽  
F Puls
Keyword(s):  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury
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