A One-Two Punch to Corneal Fibrosis and Retinal Gliosis in Alkali Injury

2020 ◽  
Vol 331 ◽  
pp. 13
Author(s):  
Royce Mohan ◽  
W. John Wizeman ◽  
Paola Bargagna-Mohan
Keyword(s):  
Alkali Injury

Topical Use of Zinc Desferrioxamine for Corneal Alkali Injury in a Rabbit Model

Cornea ◽  
1998 ◽  
Vol 17 (2) ◽  
pp. 191-195 ◽  
Author(s):  
Charalambos S. Siganos ◽  
Joseph Frucht-Pery ◽  
M. S. Muallem ◽  
Eduard Berenshtein ◽  
Irene Naoumidi ◽  
...  
Keyword(s):  
Rabbit Model ◽  
Alkali Injury

Conjunctival Impression Cytology for the Diagnosis, Follow-up, and Treatment in a Patient With Severe Keratoconjunctivitis Caused by Alkali Injury

Cornea ◽  
2009 ◽  
Vol 28 (7) ◽  
pp. 817-820 ◽  
Author(s):  
Silvia Pastor ◽  
Jose L Rodriguez-Prats ◽  
Anna Walewska-Szafran ◽  
Alejandra E Rodriguez ◽  
Jorge L Alio
Keyword(s):  
Impression Cytology ◽  
Conjunctival Impression Cytology ◽  
Alkali Injury

scholarly journals Ocular surface alkali injury damages meibomian glands in mice

2017 ◽  
Vol 15 (4) ◽  
pp. 713-722 ◽  
Author(s):  
Shin Mizoguchi ◽  
Hiroki Iwanishi ◽  
Masahide Kokado ◽  
Takayoshi Sumioka ◽  
Geraint J. Parfitt ◽  
...  
Keyword(s):  
Ocular Surface ◽  
Alkali Injury ◽  
Meibomian Glands

scholarly journals Molecular Hydrogen Effectively Heals Alkali-Injured Cornea via Suppression of Oxidative Stress

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Cestmir Cejka ◽  
Jan Kossl ◽  
Barbora Hermankova ◽  
Vladimir Holan ◽  
Jitka Cejkova
Keyword(s):  
Oxidative Stress ◽  
Proinflammatory Cytokines ◽  
Molecular Hydrogen ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Rabbit Cornea ◽  
Corneal Transparency ◽  
Corneal Hydration ◽  
Alkali Injury ◽  
Phosphate Buffered Saline

The aim of this study was to examine the effect of molecular hydrogen (H2) on the healing of alkali-injured cornea. The effects of the solution of H2in phosphate buffered saline (PBS) or PBS alone topically applied on the alkali-injured rabbit cornea with 0.25 M NaOH were investigated using immunohistochemical and biochemical methods. Central corneal thickness taken as an index of corneal hydration was measured with an ultrasonic pachymeter. Results show that irrigation of the damaged eyes with H2solution immediately after the injury and then within next five days renewed corneal transparency lost after the injury and reduced corneal hydration increased after the injury to physiological levels within ten days after the injury. In contrast, in injured corneas treated with PBS, the transparency of damaged corneas remained lost and corneal hydration elevated. Later results—on day 20 after the injury—showed that in alkali-injured corneas treated with H2solution the expression of proinflammatory cytokines, peroxynitrite, detected by nitrotyrosine residues (NT), and malondialdehyde (MDA) expressions were very low or absent compared to PBS treated injured corneas, where NT and MDA expressions were present. In conclusion, H2solution favorably influenced corneal healing after alkali injury via suppression of oxidative stress.

Effects of activated omental cells on rat limbal corneal alkali injury

2014 ◽  
Vol 121 ◽  
pp. 143-146 ◽  
Author(s):  
Ping Bu ◽  
Anita P. Vin ◽  
Periannan Sethupathi ◽  
Lindsay A. Ambrecht ◽  
Yougang Zhai ◽  
...  
Keyword(s):  
Alkali Injury
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